Navigation Links
New screening approach identified potential drug combos for difficult-to-treat melanomas
Date:12/13/2012

PHILADELPHIA A novel approach to identifying potential anticancer drug combinations revealed that pairing cholesterol-reducing drugs called statins with cyclin-dependent kinase inhibitors might provide an effective approach to treating intractable melanomas driven by mutations in the NRAS and KRAS gene.

David F. Stern, Ph.D., professor of pathology at Yale University School of Medicine in New Haven, Conn., and colleagues reported these data in Cancer Discovery, a journal of the American Association for Cancer Research.

"The identification of gene mutations that drive specific subsets of cancers has had a major beneficial impact on treatments for these patients. But, such mutations can only be identified for some cancers. Some patients who have a specific cancer-driving genetic mutation never respond to the matching drug, while nearly all those who initially respond eventually become resistant to the effects of the drug and their cancers relapse," said Stern.

For this reason, Stern and colleagues reasoned that using drug combinations may be necessary to address the problem of drug resistance and enable effective treatment of cancers driven by signaling molecules that currently cannot be targeted, such as RAS.

They developed an in vitro, high-throughput screen to test the effectiveness of anticancer drugs, alone and in pairs, against three types of melanoma cell lines: those driven by mutations in the RAS gene (representing approximately 20 percent of human melanomas), those driven by mutations in the BRAF gene (40 to 50 percent of melanomas) and those without mutations in either the RAS or BRAF genes.

Through analysis of 150 drugs as single agents, Stern and colleagues narrowed their pool to 40 drugs for combination testing. Melanoma cell lines driven by BRAF and RAS were sensitive to different combinations of drugs. Some combinations that killed BRAF-driven melanoma cell lines were also effective agains
'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
215-446-7109
American Association for Cancer Research
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Discovery in Ghent could improve screening for sudden cardiac death
2. Earphones, music players on kids holiday gift lists? Add a hearing screening
3. Are there racial disparities in osteoporosis screening and treatment?
4. Cancer screening: The efficacy of mammography screening
5. Cardiac Screening for All Young Athletes Carries Big Price Tag: Study
6. Women With Dense Breasts Open to Additional Cancer Screening: Study
7. Women with dense breasts welcome additional screening
8. Preventive screening for sudden cardiac death in young athletes debated
9. BioMAP screening procedure could streamline search for new antibiotics
10. U.S. Task Force Backs HIV Screening for All 15 to 65
11. Novel breast screening technology increases diagnostic accuracy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/19/2013)... (PRWEB) May 19, 2013 In partnership with ... E-dentist.com has announced the launch of an SEO website for ... get high rankings in Google. , http://www.e-dentists.com/ , ... pay for the service until they see results. Dentists can ... lead generation websites run by JD Media Surge, LLC rank ...
(Date:5/19/2013)... Today, Zane Benefits, Inc. published ... insurance . Zane Benefits, which provides comprehensive and ... is the leader in health care reform, ... . , According to Zane Benefits’ website, many ... the value of small business health insurance for ...
(Date:5/19/2013)... May 19, 2013 6Webs.com is the ... companies. Homeowners who are considering an alarm system can ... the nation's leading security system providers online at 6Webs.com. ... best DIY home security system companies, 6Webs.com ... reviews dozens of home security companies before ranking the ...
(Date:5/19/2013)... Seattle, Wa (PRWEB) May 19, 2013 ... new fat loss program that provides people with ... instructions. When people order this Fat Burning Furnace package, ... other materials that they can download quickly. The Fat ... information that helps people build lean muscle mass. In ...
(Date:5/19/2013)... Farming methods have changed many times since man ... ago. Most recently, the Green Revolution has transformed farming ... seeds and by applying chemical fertilizers and pesticides. But ... due to the adverse environmental and health effects of ... interest in organic, sustainable farming practices and techniques. Enter ...
Breaking Medicine News(10 mins):Health News:Effective New Dental SEO Solution Launched by E-dentists.com in Partnership with JD Media Surge, LLC 2Health News:Zane Benefits Publishes New Information on Small Business Health Insurance 2Health News:Zane Benefits Publishes New Information on Small Business Health Insurance 3Health News:Top Rated DIY Home Security System Companies Published by 6Webs.com 2Health News:Fat Burning Diet | How “Fat Burning Furnace” Helps People Lose Their Weight Naturally And Fast – V-kool 2Health News:Green Acre Aquaponics Introduces a Revolutionary Approach to Farm Education and Commercial Aquaponics 2Health News:Green Acre Aquaponics Introduces a Revolutionary Approach to Farm Education and Commercial Aquaponics 3
... NEW YORK, March 12 On the second annual ... are working together to help educate patients diagnosed with ... the condition. Glaucoma is a worldwide epidemiological challenge affecting ... estimated 50 percent of glaucoma cases remaining undiagnosed. ...
... exposure to cold and flu virusesCLEVELAND, March 12 ... Postgraduate Medicine suggests that a strain of ... GBI-30, PTA-6086), increases the body,s immune response to viruses ... colds and flu. Study data showed significant increases ...
... to have aggressive brain surgery after suffering a severe ... to live longer, according to research by neurologists at ... should help patients and families put into perspective a ... make whether putting a patient through aggressive surgery ...
... to mathematics to build a computerized 3D model ... and other clothes designers make more sensuous, comfortable, ... Kensuke Nakamura of Kyoto Institute of Technology and ... components is critical for designing close-fitting products, whether ...
... Provides Safe, Secure and Effective Ways for Physicians ... to More Than 1,000 Healthcare Connections Across AmericaCARROLLTON, ... recently announced the 1,000th connection of Prime Exchange ... that allows data to be electronically shared between ...
... MIAMI, March 12 March 12 has been proclaimed ... globe. According to the World Health Organization, more ... suffer horribly from total incurable Glaucoma-Blindness. Most lacked the ... slowly robbed them of all their sight. Dr. Robert ...
Cached Medicine News:Health News:VIDEO from Medialink and Pfizer Ophthalmics: On World Glaucoma Day, Keep an Eye on the Future 2Health News:New Study Shows Probiotic Strain Effective in Boosting Immune Response 2Health News:New Study Shows Probiotic Strain Effective in Boosting Immune Response 3Health News:New Study Shows Probiotic Strain Effective in Boosting Immune Response 4Health News:Weighing the options after life-altering stroke 2Health News:Weighing the options after life-altering stroke 3Health News:Weighing the options after life-altering stroke 4Health News:Studying the female form 2Health News:Greenway Medical Technologies' Interoperability Engine, PrimeExchange, Allows Physicians to Securely Share Patient Data Amongst Wide Range of Providers in Patient's Care Continuum 2Health News:Greenway Medical Technologies' Interoperability Engine, PrimeExchange, Allows Physicians to Securely Share Patient Data Amongst Wide Range of Providers in Patient's Care Continuum 3Health News:Greenway Medical Technologies' Interoperability Engine, PrimeExchange, Allows Physicians to Securely Share Patient Data Amongst Wide Range of Providers in Patient's Care Continuum 4Health News:Greenway Medical Technologies' Interoperability Engine, PrimeExchange, Allows Physicians to Securely Share Patient Data Amongst Wide Range of Providers in Patient's Care Continuum 5Health News:Welsh 'Self-Test' to Help Cure Glaucoma on World Glaucoma Day 2
(Date:5/16/2013)... MECHELEN, Belgium , May 17, 2013 ... ABBV ) announced today an extension of ... Galapagos will fund and complete a Phase 2 program ... progression into Phase 3.  Upon successful completion of the ... $50 million.  The terms of the collaboration extension are ...
(Date:5/16/2013)... Therapeutics, (Nasdaq: NKTR ) President and Chief Executive ... to present at the upcoming 2013 UBS Global Healthcare Conference ... New York Hotel on Tuesday, May 21, 2013 at 10:00 ... via a Webcast through a link posted in the Investor ... . This Webcast will be available for replay until June ...
(Date:5/16/2013)... , May 16, 2013  HeartWare International, Inc. (NASDAQ: ... of less invasive, miniaturized circulatory support technologies that are revolutionizing ... Doug Godshall is scheduled to present ... EDT on Monday, May 20, 2013.  The conference is being ... A live webcast of the Company,s presentation at ...
Breaking Medicine Technology:AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 2AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 3AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 4AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 5AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease 6Nektar Therapeutics' President and CEO, Howard W. Robin, To Present at the 2013 UBS Global Healthcare Conference in New York City 2HeartWare Presentation At The 2013 UBS Global Healthcare Conference To Be Webcast 2
... are ideal for PCR and ... any work where aerosol contamination ... for pipetting DNA/RNA solutions, infectious ... For applications requiring absolute sterility, ...
Inquire...
... Filters are ideal for PCR ... for any work where aerosol ... designed for pipetting DNA/RNA solutions, ... other. For applications requiring absolute ...
... Aerosol barrier tips eliminate false signals ... designed and tested, Promega Barrier Tips ... with amplified nucleic acids (PCR(a)), radioactive ... forensic and serological specimens. , ,Promega ...
Medicine Products: