Navigation Links
New route to map brain fat
Date:5/4/2011

Mapping the fat distribution of the healthy human brain is a key step in understanding neurological diseases, in general, and the neurodegeneration that accompanies Alzheimer's disease in particular. Antonio Veloso and colleagues, from the University of the Basque Country in Leioa, Spain, find a new technique to reveal the fat distribution of three different areas of the healthy human brain. Their work is published online in Springer's journal, Analytical & Bioanalytical Chemistry.

The human central nervous system has an abundance of lipid molecules - some are structural and energetic components of cells; others play a role in neurotransmission and are known as neurolipids. Mapping these neurolipids can increase neurologists' knowledge of the precise metabolic routes that produce them and where this production takes place. Knowing the fat composition of the healthy brain and the distribution of the different lipid species can give them clues about how neurodegenerative diseases develop.

The multi-disciplinary team used a combination of MALDI-TOF imaging mass spectrometry (a technique used to visualize the spatial distribution of compounds by their molecular mass) and functional autoradiography (an image recorded on a photographic film that shows the distribution of the activity induced by a drug) to scan healthy brain tissue slices. They mapped out, in detail, the lipid distribution of 43 types of lipids in three distinct areas of the human brain: the frontal cortex, hippocampus and striatum.* What is unique about their method, is its ability to identify the lipid species as well as locate them. Indeed, localization of lipid species is lost with the use of traditional techniques.

The authors conclude: "The application of imaging mass spectrometry to the localization of lipid species in the brain will be especially helpful to elucidate the specific functions of each type of lipid. Moreover, during the last few years the modulation of the signaling by neurolipids has been found to be implicated in neurodegenerative diseases. In this context, Alzheimer's disease is especially interesting since the familial mutation of some proteins that transport lipids, as the Apolipoprotein E, is a risk factor in this disease. The imaging mass spectrometry technique is still in an early stage. It is expected that in the near future, new hardware developments will allow a precise determination of an increasing number of lipid species, aiming at producing a three-dimensional map of the lipid distribution in the brain."


'/>"/>

Contact: Joan Robinson
joan.robinson@springer.com
49-622-148-78130
Springer
Source:Eurekalert

Related medicine news :

1. Animal studies reveal new route to treating heart disease
2. Researchers unzip MRSA and discover route for vaccine
3. Crucial sex hormones re-routed by missing molecule
4. Mouse Study Reveals a Cancer Cell Escape Route
5. Selected cells from blood or bone marrow may provide a route to healing blood vessels
6. CradlePoint Router and Mobile Broadband Adapter Pair With Sprint 4G to Create Instant Offices, Business Continuity Solutions
7. Network Latency Improvement Creates One of the Fastest Routes between Chicago and Newark/New York City
8. ShelterBox Aid en route to Mexico Following Earthquake
9. Sense of justice built into the brain
10. Ecstasy associated with chronic change in brain function
11. Most patients recover from chemo-brain by 5 years after stem cell transplant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... While it’s often important to take certain medications during the night, finding ... identified a solution. , She developed a prototype for MOTION LIGHT-UP PILL BOX to ... the need to turn on a light when taking medication during the night, allowing ...
(Date:10/13/2017)... IL (PRWEB) , ... October 13, 2017 , ... ... which established the certification process to promote standards of excellence for the field ... Symposium, scheduled for March 22 – 25, 2018 in Orlando, Florida at the ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along ... updates for the primary prevention of cardiovascular diseases during the 15th Annual ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes , ... mock evacuation of the facility as part of a disaster drill on October 3rd. ... EMS and Shelton City Emergency Manager, as well as the Connecticut Long Term ...
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... Pa. , Oct. 12, 2017 ... leader in innovative solutions for injectable drug administration, today ... before the market opens on Thursday, October 26, 2017, ... the results and business expectations at 9:00 a.m. Eastern ... (U.S.) or 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
(Date:10/4/2017)... WESTWOOD, Mass. , Oct. 4, 2017  According to the Centers ... by the end of October . PhysicianOne Urgent Care is helping communities ... Westchester, NY , by offering no-cost* flu shots through ... , as mandated by certain health insurance regulations. ... The best time to get a flu shot is by ...
Breaking Medicine Technology: