Navigation Links
New role for an old molecule: protecting the brain from epileptic seizures
Date:3/6/2011

ith the Brown Institute for Brain Science. It took about a dozen more experiments before his team, led by graduate student Mark Bell, could solve the mystery.

First they hindered polyamine synthesis altogether and found that not only did the protection against seizures disappear, but it also left the tadpoles even more vulnerable to seizures. Then they interrupted the conversion of putrescine into other polyamines and found that this step enhanced the protection, indicating that putrescine was the beneficial member of the family.

Going with those results, they administered putrescine directly to the tadpoles and found that it took 65 percent longer to induce a seizure than in tadpoles that didn't get a dose of putrescine.

Further experiments showed that the protective effect occurs after putrescine is metabolized, with at least one intermediary step, into GABA, and GABA receptors are activated in brain cells.

"Potentially by manipulating this pathway we may be able to harness an ongoing protective effect against seizures," Aizenman said. "However I should caution that this is basic research and it is premature to predict how well this would translate into the clinic."

In the meantime, the research may also help explain a bit more about young brains in general, Aizenman said.

"Our findings may also tell us how normal brains, especially developing brains, may regulate their overall levels of activity and maybe keep a type of regulatory check on brain activity levels," he said.


'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Protecting patients: Study shows that Johns Hopkins flu vaccination rates twice national average
2. Protecting the brain from of a deadly genetic disease
3. Protecting the brain from a deadly genetic disease
4. Strategies increase health-care worker vaccination rates -- protecting patients
5. ASTRO publishes supplement on protecting cancer patients by reducing radiation doses, side effects
6. Protecting Global Travelers with New Security Solutions
7. Smoke-free air laws effective at protecting children from secondhand smoke
8. Beating doctor burnout and protecting patients
9. Preventing GVHD by protecting gut stem cells
10. Gadgets not related to teenagers brain pain
11. Dementia Rates Escalate as Brain Capacity Diminishes with Age
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 20, 2014 Allegheny General Hospital’s (AGH) ... enables physicians to repair a damaged mitral valve as ... system, developed by Abbott Vascular , is ... and life-threatening condition in which the heart’s mitral valve ... backward from the heart’s left ventricle into the left ...
(Date:10/20/2014)... 2014 hc1.com today announced the ... solution that enables healthcare organizations of all sizes ... customer relationship management (“CRM”) solution. , Designed from ... of the healthcare industry, the hc1 Healthcare Relationship ... patients by combining healthcare CRM, HIPAA-compliant collaboration, and ...
(Date:10/20/2014)... AttorneyOne.com, a recognized authority on law, update the ... on Sit and Slim II . , The ... use Sit and Slim II because it contains Sibutramine ... weight loss product on various websites and possibly in some ... for safety reasons, can significantly increase blood pressure and/or pulse ...
(Date:10/20/2014)... 2014 National Teen Driver Safety Week is ... Academy of Pediatrics (Ohio AAP, http://www.ohioaap.org ) is joining ... of teen drivers to talk to their teens and always ... vehicle crashes are the leading cause of death for U.S. ... fatal crashes, and 859 (42%) of those teen drivers were ...
(Date:10/20/2014)... Houston plastic surgeon Dr. Christopher Patronella ... his innovative True Form Tummy Tuck® method ... faculty at The University of Texas Medical Branch ... a medical student. Patronella, who is a founding partner ... practices in Texas, The Aesthetic Center for Plastic ...
Breaking Medicine News(10 mins):Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 2Health News:Allegheny General Hospital Introduces New, Beating-Heart Procedure for Mitral Valve Repair 3Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2Health News:FDA Advises Not to Use Sit and Slim II: AttorneyOne Monitors and Keeps Consumers Informed 2Health News:Ohio AAP Promotes National Teen Driver Safety Week 2Health News:Plastic Surgeon Patronella Presents Artistically-Inspired Tummy Tuck Method to Future Generation of Plastic Surgeons in Texas 2
... FL, July 6, 2010 Embargoed by the journal ... Scientists from The Scripps Research Institute have found that ... in determining vulnerability to cocaine addiction and may offer an ... animal studies, the scientists found that a molecule called microRNA-212 ...
... of dental care continues to be a significant problem for American ... to dental disease. A new study published in ... that in California, nearly 25 percent of children have never seen ... of insurance when it comes to the duration between dental care ...
... HealthDay Reporter , WEDNESDAY, July 7 (HealthDay News) -- ... is less accurate when done in the summer than in ... Although the particular brand of test used in the study ... United States, the findings are of interest to U.S. researchers ...
... By Steven Reinberg HealthDay Reporter , TUESDAY, July ... or no relief for sufferers of chronic lower back pain ... trial seems to be another knock against glucosamine, with other ... questions: ,I have suffered low back pain for a long ...
... ... of a State-of-the-Art Hospital in Rural Kenya. Founded by a Kaiser Permanente Oncologist, ... Foundation,s Investment Management Approach to African Philanthropy is a Departure from Traditional Grant-making. ... (PRWEB) July ...
... ... outlines considerations when applying for SSDI with spinal cord impairments , ... Belleville, Ill. (Vocus) -- Every 41 ... 11,000 new cases each year, according to the United Spinal Association. Allsup, a nationwide ...
Cached Medicine News:Health News:Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use 2Health News:Scripps Research scientists uncover previously unknown natural mechanism that controls cocaine use 3Health News:1 in 4 Californian children have never seen a dentist, study finds 2Health News:Could Hot Weather Affect Results of a Colorectal Cancer Test? 2Health News:Could Hot Weather Affect Results of a Colorectal Cancer Test? 3Health News:Could Hot Weather Affect Results of a Colorectal Cancer Test? 4Health News: Glucosamine Ineffective for Lower Back Pain Linked to Arthritis 2Health News: Glucosamine Ineffective for Lower Back Pain Linked to Arthritis 3Health News:State of the Art Hospital for Rural Kenya Announced by California Foundation 2Health News:State of the Art Hospital for Rural Kenya Announced by California Foundation 3Health News:Social Security Disability Benefits Can Be Crucial to Surviving With Spinal Cord Injury, Allsup Reports 2Health News:Social Security Disability Benefits Can Be Crucial to Surviving With Spinal Cord Injury, Allsup Reports 3Health News:Social Security Disability Benefits Can Be Crucial to Surviving With Spinal Cord Injury, Allsup Reports 4
(Date:10/17/2014)... Oct. 17, 2014 With the recent ... function has come across several challenges in creating ... managing globalization.  The Medical ... dedicated to providing benchmarking and best practices across ... is a service composed of three stages: 1) ...
(Date:10/17/2014)...  Amgen (NASDAQ: AMGN ) today announced ... president of Gladstone Institutes and Gladstone,s Robert W. and ... are pleased to welcome Dr. Sandy Williams ... , chairman and chief executive officer of Amgen. "Dr. ... his direct experience in our industry will both be ...
(Date:10/17/2014)... , Oct. 17, 2014 Research ... "Research and Development Prospect of China Dialysis ... Based on the 2013 version, this ... policies about dialysis industry and the relevant effect ... about dialysis industry segmentations. Moreover, it analyzes Chinese ...
Breaking Medicine Technology:Early Key Findings from the Medical Affairs Consortium Research 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 2Amgen Announces Appointment Of R. Sanders Williams To Board Of Directors 3Research and Development Prospect of China Dialysis Market, 2014-2018 2Research and Development Prospect of China Dialysis Market, 2014-2018 3
... Incorporated (Nasdaq: ARAY ), a global leader in ... fourth quarter and fiscal year 2010, ended June 30, 2010. ... Accuray reported total revenue of $61.8 million, a 5.1 percent ... of $58.8 million. For the fiscal year ended June 30, ...
... 31 Reportlinker.com announces that a new market ... The Global Orthobiologics Market - Players, ... http://www.reportlinker.com/p0192725/The-Global-Orthobiologics-Market---Players-products-and-technologies-driving-change-2008.html The primary ... factors compared with allograft bone tissue is that ...
Cached Medicine Technology:Accuray Announces Results for Fourth Quarter and Fiscal Year 2010 2Accuray Announces Results for Fourth Quarter and Fiscal Year 2010 3Accuray Announces Results for Fourth Quarter and Fiscal Year 2010 4Accuray Announces Results for Fourth Quarter and Fiscal Year 2010 5Accuray Announces Results for Fourth Quarter and Fiscal Year 2010 6Reportlinker Adds The Global Orthobiologics Market - Players, products and technologies driving change 2008 2Reportlinker Adds The Global Orthobiologics Market - Players, products and technologies driving change 2008 3Reportlinker Adds The Global Orthobiologics Market - Players, products and technologies driving change 2008 4Reportlinker Adds The Global Orthobiologics Market - Players, products and technologies driving change 2008 5
... Drug Discovery, Biotechnology, Genomic and Proteomic ... Quality Control over Sample Preparation capability ... advanced benchtop ventilated centrifuge accommodates 4x750 ... capacity production throughput. High throughput screening, ...
... A common sight in laboratories ... providing rugged, dependable centrifuge standards for ... laboratories. The Model K's simple, classic ... make it a standard for centrifuge ...
Inquire...
... Use of the Hybridization Oven/Shaker rigidly ... ensuring the stringency of hybridization and ... and reproducible probing of nucleic acids ... Developed for use with radioactive and ...
Medicine Products: