Navigation Links
New role discovered for molecule important in development of the pancreas
Date:7/10/2009

PHILADELPHIA For years researchers have been searching for a way to treat diabetics by reactivating their insulin-producing beta cells, to no avail. Now, they may be one step closer. A protein, whose role in pancreatic development has long been recognized, has been discovered to play an additional and previously unknown regulatory role in the development of cells in the immature endocrine system. These cells ultimately give rise to pancreatic islet cells, which include beta cells.

By carefully defining the developmental steps and genetic circuits that lead to mature beta cells, researchers may be able to one day mimic these developmental processes, thereby facilitating beta-cell growth in the lab, and eventually, new therapies. The findings appear in the July 2009 issue of the Journal of Clinical Investigation.

"The protein, Pdx1, is a pivotal molecule in the regulation of beta-cell development and we hope this type of information could help in efforts to generate beta-cell replacements for the treatment of diabetes," says senior author Doris Stoffers, MD, PhD, Associate Professor of Medicine at the University of Pennsylvania School of Medicine. Stoffers is also a member of the Institute for Diabetes, Obesity, and Metabolism at Penn.

Pdx1 is a key regulator of pancreatic development and adult beta-cell function. For example, loss of a single copy of Pdx1 in mice leads to diabetes; loss of two copies leads to a complete failure of the pancreas to form. This new research expands the role of Pdx1 in beta-cell biology in the developing embryo.

Ultimately, Stoffers says, these findings could help researchers intent on developing cell-based therapeutic approaches to diabetes though such advances are a long way off. Both type 1 and type 2 diabetes are caused by a loss of insulin-producing beta cells. In theory, transplantation of fresh beta cells should halt the disease, yet researchers have not yet been able to genera
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. New Prostate Cancer Biomarker Discovered
2. New arenavirus discovered as cause of hemorrhagic fever outbreak in South Africa and Zambia
3. PAs First West Nile Positive Sample of 2009 Discovered in York County
4. New Treatment Discovered for Restless Legs Syndrome Improves Sleep
5. New target for maintaining healthy blood pressure discovered
6. Key protein in cellular respiration discovered
7. AstraZeneca Licenses Novel Antidepressant Compounds Discovered by Mayo Clinic and Virginia Tech Collaboration
8. Ten new amphibian species discovered in Colombia
9. Gene Discovered for Most Common Form of Epilepsy
10. Possible Alzheimers disease marker discovered in rare genotype
11. Prostate Cancer Discovered in 40 Percent of Men Who Test Negative for the Disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New role discovered for molecule important in development of the pancreas
(Date:12/20/2014)... 20, 2014 Developers of FCPX ... a new plugin for Final Cut Pro X entitled ... Volume 5 allows users to create hand drawn text ... Christina Austin, CEO of Pixel Film Studios. “TranSlice Volume ... while maintaining an easy to use interface.” , TranSlice ...
(Date:12/19/2014)... December 20, 2014 Today, Balfleet.com ... special-occasion outfits, announces its formal dress promotion. All the ... up to 60% off. , Balfleet.com is well-known for ... bridesmaid dresses, prom dresses, cocktail dresses and more. Its ... 30-day money-back guarantee, and they can create an elegant ...
(Date:12/19/2014)... CA (PRWEB) December 19, 2014 ... corporation dedicated to developing educational events, tools and ... Rouxbe Cooking School , the world’s leading ... the prescription every human being needs: Culinary Rx. ... plant-based cooking course, Culinary Rx, scheduled for debut ...
(Date:12/19/2014)... 20, 2014 An evening dress is perfect ... lady’s closet. Discount-Dress.com, a distinguished dresses retailer, has unveiled its ... dresses in this great shopping platform. Customers can ... staff's hard work, Discount-Dress.com has been accepted and praised by ... and easier shopping stage for clients. In order to expand ...
(Date:12/19/2014)... FRIDAY, Dec. 19, 2014 (HealthDay News) -- All children ... 3 and 6, preferably every year, eye experts say. ... from an expert panel of the U.S. National Center ... children in this age group require screening for eye ... glasses, such as amblyopia ("lazy eye") and strabismus (a ...
Breaking Medicine News(10 mins):Health News:Pixel Film Studios released a new transition entitled TranSlice Volume 5 exclusively for Final Cut Pro X 2Health News:Balfleet.com Announces Its Formal Dress Promotion For 2015 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 2Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 3Health News:The Plantrician Project and the Rouxbe Cooking School Join Forces to Develop Culinary Rx – a Plant-Prescription Course 4Health News:Attractive Evening Dresses Announced by Discount-Dress.com 2Health News:Preschoolers Need Eye Screening, Experts Say 2
... to repair nerve fiber damage , , TUESDAY, April 28 ... and stabilize damage done to the myelin sheath in people ... Idec and Elan Corp shows. , MS is nervous system ... by MS patients are caused by damage to the myelin ...
... 29 /PRNewswire-Asia-FirstCall/ -- Shengtai,Pharmaceutical, Inc. (OTC Bulletin ... manufacturer and distributor of high-quality, pharmaceutical grade,glucose ... hosted a conference at the,Company,s headquarters to ... as well as conducted,high-level discussions with key ...
... 29 , - Bausch ... Campaign , Bausch & Lomb ... in its continued effort to improve the habits of,contact ... the THINK,EYEGIENE(TM) campaign, Bausch & Lomb is introducing ReNu ...
... 2009 First Quarter Reported Diluted Earnings per Share were $0.89, ... per Share, , Excluding Certain Significant Items, Increased ... First Quarter and , Increased 2%, Excluding the ... the Impact of Foreign , Exchange, was Driven ...
... 2009 AT 13.00 CET -- Advances in ... diseases and make ever more accurate diagnoses. But ... (IAEA) say that overuse of high-tech scanning procedures may ... IAEA, in collaboration with other international organizations, is developing ...
... Bill to Advance Education and Informed Consent Recommendations Established ... Cord Blood Registry (CBR), the global ... cells from umbilical cord blood, announced its support of ... entitled the "Cord Blood Education and Awareness Act of ...
Cached Medicine News:Health News:Shengtai Pharmaceutical Hosts Key Customers at Its Headquarters for Facility Tour and Technology Exchange Conference 2Health News:Shengtai Pharmaceutical Hosts Key Customers at Its Headquarters for Facility Tour and Technology Exchange Conference 3Health News:A Clear Solution for Healthy Eyes 2Health News:A Clear Solution for Healthy Eyes 3Health News:A Clear Solution for Healthy Eyes 4Health News:Wyeth Reports Earnings Results for the 2009 First Quarter 2Health News:Wyeth Reports Earnings Results for the 2009 First Quarter 3Health News:Wyeth Reports Earnings Results for the 2009 First Quarter 4Health News:Wyeth Reports Earnings Results for the 2009 First Quarter 5Health News:Wyeth Reports Earnings Results for the 2009 First Quarter 6Health News:Wyeth Reports Earnings Results for the 2009 First Quarter 7Health News:Wyeth Reports Earnings Results for the 2009 First Quarter 8Health News:Wyeth Reports Earnings Results for the 2009 First Quarter 9Health News:Wyeth Reports Earnings Results for the 2009 First Quarter 10Health News:Wyeth Reports Earnings Results for the 2009 First Quarter 11Health News:Wyeth Reports Earnings Results for the 2009 First Quarter 12Health News:IAEA calls for enhanced radiation protection of patients 2Health News:IAEA calls for enhanced radiation protection of patients 3Health News:IAEA calls for enhanced radiation protection of patients 4Health News:IAEA calls for enhanced radiation protection of patients 5Health News:Cord Blood Registry Supports Introduction of the Cord Blood Education and Awareness Act of 2009 2Health News:Cord Blood Registry Supports Introduction of the Cord Blood Education and Awareness Act of 2009 3
(Date:12/19/2014)... membrane market has witnessed robust development with the growth pace ... later starter. In 2012, the size of China ... the proportion worldwide soaring to 16.3%. It is projected that ... its growth rate by around 20% in the upcoming years ... RMB25 billion. An integrated membrane industrial system has ...
(Date:12/17/2014)... Germany , December 17, 2014 ... level of expenditure on research and development In ... increased its revenue by two percent to EUR 4.287 billion ... (EBIT) grew by 14 percent to EUR 360 million. "Overall, ... said Dr. Michael Kaschke , President and CEO of ...
(Date:12/17/2014)... Dec. 17, 2014 With advancements in ... MRI market is seeing new growth, according to ... scans account for the majority of market volume, ... of images, which are creating opportunities for more sophisticated ... is growing at a rate of 4%, with ...
Breaking Medicine Technology:Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 3ZEISS Asserts its Position in Difficult Environment 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3
... Amendment to Existing Senior Secured Credit Facilities and Closes Senior... -- ARDEE, Ireland, Aug. 20 ... ... lpUnit=,PRN,; --> ... var s = ,; var first_result; // Results are keyed by longUrl, so we need to ...
... Corporation,s (OTC Bulletin Board: ETCC ) ... leader in the development, manufacture of computerized monoplace ... FDA 510-k clearance for O.S.C.A.R. ™.  O.S.C.A.R. ™ ... And Recording." This computerized system is configured as ...
Cached Medicine Technology:Warner Chilcott Completes Amendment to Existing Senior Secured Credit Facilities and Closes Senior Notes Offering; Company Declares Special Cash Dividend of $8.50 Per Share and Updates Full-Year 2010 Financial Guidance 2Warner Chilcott Completes Amendment to Existing Senior Secured Credit Facilities and Closes Senior Notes Offering; Company Declares Special Cash Dividend of $8.50 Per Share and Updates Full-Year 2010 Financial Guidance 3Warner Chilcott Completes Amendment to Existing Senior Secured Credit Facilities and Closes Senior Notes Offering; Company Declares Special Cash Dividend of $8.50 Per Share and Updates Full-Year 2010 Financial Guidance 4Warner Chilcott Completes Amendment to Existing Senior Secured Credit Facilities and Closes Senior Notes Offering; Company Declares Special Cash Dividend of $8.50 Per Share and Updates Full-Year 2010 Financial Guidance 5Warner Chilcott Completes Amendment to Existing Senior Secured Credit Facilities and Closes Senior Notes Offering; Company Declares Special Cash Dividend of $8.50 Per Share and Updates Full-Year 2010 Financial Guidance 6Warner Chilcott Completes Amendment to Existing Senior Secured Credit Facilities and Closes Senior Notes Offering; Company Declares Special Cash Dividend of $8.50 Per Share and Updates Full-Year 2010 Financial Guidance 7Warner Chilcott Completes Amendment to Existing Senior Secured Credit Facilities and Closes Senior Notes Offering; Company Declares Special Cash Dividend of $8.50 Per Share and Updates Full-Year 2010 Financial Guidance 8Warner Chilcott Completes Amendment to Existing Senior Secured Credit Facilities and Closes Senior Notes Offering; Company Declares Special Cash Dividend of $8.50 Per Share and Updates Full-Year 2010 Financial Guidance 9Warner Chilcott Completes Amendment to Existing Senior Secured Credit Facilities and Closes Senior Notes Offering; Company Declares Special Cash Dividend of $8.50 Per Share and Updates Full-Year 2010 Financial Guidance 10Warner Chilcott Completes Amendment to Existing Senior Secured Credit Facilities and Closes Senior Notes Offering; Company Declares Special Cash Dividend of $8.50 Per Share and Updates Full-Year 2010 Financial Guidance 11ETC Biomedical Systems Offers New FDA Approved Hyperbaric Oxygen Therapy (HBOT) Medical Device 2ETC Biomedical Systems Offers New FDA Approved Hyperbaric Oxygen Therapy (HBOT) Medical Device 3ETC Biomedical Systems Offers New FDA Approved Hyperbaric Oxygen Therapy (HBOT) Medical Device 4
... family of products offers complete electronic ... specialties. Intuition EMR enables physicians to ... record at the point of care, ... time on documentation and more time ...
... the most successful EMR in the ... facilitate improvements that deliver measurable returns. ... from our clients abound, from reducing ... satisfaction. They have realized significant financial ...
... You'll never have to hunt for a ... copies of every document and more are ... folder. Charting Plus EMR is an effective ... specialties. Designed with the user in mind, ...
... Eyecare Advantage is one of our ... practice management software is what Compulink ... Compulink is among today's leaders in ... Eyecare Advantage integrates all the functionality ...
Medicine Products: