Navigation Links
New risk factor for developing breast cancer
Date:11/10/2010

An Australian research team from the Peter MacCallum Cancer Centre, the University of Melbourne and the University of Queensland has identified a new risk factor for developing breast cancer. This has been published online in the journal Cancer Prevention Research.

The risk factor involves a modification (DNA methylation) to the BRCA1 gene. BRCA1 is known for its involvement in breast and ovarian cancer. Women with mutations in this gene, which inactivates its function, are predisposed to these diseases.

The DNA methylation modification is known as an epimutation and acts to turn off the BRCA1 gene from its normal protective function against breast cancer. It is not considered a genetic mutation as it does not directly affect the sequence of the gene like a mutation but nevertheless inactivates the normal protective function of the gene.

The study involved women diagnosed with breast cancer before the age of 40 years for whom BRCA1 mutations had not been identified. The epimutation was found in the blood of some women with breast cancer, especially those who develop the same type of breast cancer that develops in women with a BRCA1 mutation. However, unlike mutations in the BRCA1 gene, these epimutations appear not to be inherited and the relatives of women with epimutations are not at increased risk of breast or ovarian cancer.

Professor Melissa Southey from the University of Melbourne Department of Pathology, co-leader of the Australian Breast Cancer Family Study and a senior author on the paper said factors that triggered epimutations that stopped the gene BRCA1 from doing its usual job of preventing breast cancer might cause the same proportion of early-onset breast cancers (10%) as do inherited faults in this gene.

"For about 3-4% of young women, their BRCA1 gene has been made less capable of preventing breast cancers by some unknown factors. This places them at a 3.5-fold increased risk of breast ca
'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Growth factor regenerates tooth supporting structures: Results of a large randomized clinical trial
2. Taking the fear factor out of cancer
3. Fox Chase researchers identify risk factors for the spread of breast cancer to lymph nodes
4. Childhood stroke study identifies the contraceptive pill and smoking as risk factors
5. Study identifies 5 risk factors for late-stage head and neck cancer
6. UC San Diego researchers identify factor boosting leukemias aggressiveness
7. Hospital readmission studies: Influencing factors identified
8. Lifestyle intervention improves risk factors in type 2 diabetes
9. MSU researcher awarded $14 million to identify breast cancer risk factors
10. Molecular playbook for halting heart failure risk factor uncovered
11. Genetic factor in osteoporosis discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2015)... NE (PRWEB) April 18, 2015 ... in healthcare staffing, including physical therapy jobs, has ... at the South Carolina Physical Therapy Association Annual ... the Kroc Center in Greenville, SC. , ... opportunities, and exhibits with products and services. ...
(Date:4/17/2015)... Heritage Woods of McLeansboro, a Gardant affordable assisted ... on April 20 with a day full of activities ... soul. , The community, which is located at 605 ... all incomes, including those on Medicaid, who need some ... is observed every April and highlights the communities within ...
(Date:4/17/2015)... 2015 Riviera Magazine has ... of the Gallery of Cosmetic Surgery in Newport ... experts. The publication focused on his expertise in ... fat grafting, eyelid surgery, laser resurfacing and rhinoplasty. , ... has resulted in thousands of satisfied patients across ...
(Date:4/17/2015)... 17, 2015 From the day Dr. Todd ... Texas non-profit organization has empowered young people to create meaningful ... bring fresh water and the Gospel to all of ... Between March 17 and 27, students, faculty and staff raised ... with fresh water and the Good News of Jesus. ...
(Date:4/17/2015)... Grand Rapids, MI (PRWEB) April 17, 2015 ... for CRUSH Grand Rapids, Saturday, April 25, 2015. The event ... at Reserve Wine & Food (201 Monroe Ave NW, Grand ... chefs from around the West Michigan area. Patrons are encouraged ... night of elegance and fun. , This year’s event will ...
Breaking Medicine News(10 mins):Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the South Carolina Physical Therapy Association Annual Conference 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 2Health News:Heritage Woods of McLeansboro Affordable Assisted Living to Celebrate Supportive Living Week 3Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 2Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 3Health News:The Last Well and Liberty U’s TEN Initiative raises $21,000 to Bring Fresh Water & The Gospel to 7,000 Liberians 2Health News:Children’s Leukemia Foundation of Michigan Presents 3rd Annual CRUSH Grand Rapids 2
... Listed on Product Labels Due to Weak Regulatory StandardsWASHINGTON, ... "pure," dozens of top-selling children,s bath products are contaminated ... product test results released today by the ... not disclosed on product labels because contaminants are exempt ...
... past three decades, employers have been looking for ways ... pinning their hopes on a relatively new idea -- ... with tax-favored accounts. The Employee Benefit Research Institute,s (EBRI) ... in Health Care -- 30 Years into the Experiment," ...
... experts in cancer and nutrition are meeting in Zurich, ... one of the most important and fiercely debated topics ... , There is growing evidence that many cancers ... balanced diet. In addition, nutritional problems can also have ...
... tails sported by many male birds in the tropics look ... disadvantage when fleeing predators, but experiments by University of California, ... in speed or energy at least in hummingbirds. , ... daily metabolic costs by 1 to 3 percent, which means ...
... BRAINTREE, Mass., March 12 North American application activity ... February, year-over-year, according to the MIB Life Index ... was up +12.9%. Year-to-date (YTD), North American activity ... last year. Percent changes in February,s Life Index ...
... Win Tickets to Private Concert through Online SweepstakesPARSIPPANY, N.J., ... offering consumers the opportunity to attend a private Wynonna ... place on July 11th at the Country Music Hall ... the brand,s spokesperson, in an intimate setting while she ...
Cached Medicine News:Health News:Children's Bath Products Contaminated With Formaldehyde, 1,4-Dioxane 2Health News:Children's Bath Products Contaminated With Formaldehyde, 1,4-Dioxane 3Health News:EBRI Policy Forum: Consumer/Patient Engagement in Health Care - 30 Years On 2Health News:New data on link between cancer and nutrition discussed at European symposium 2Health News:Long, sexy tails not a drag on male birds 2Health News:Long, sexy tails not a drag on male birds 3Health News:Long, sexy tails not a drag on male birds 4Health News:MIB Life Index Reports North American Life Insurance Activity up 1.1% in February 2Health News:MIB Life Index Reports North American Life Insurance Activity up 1.1% in February 3Health News:Wynonna Judd and alli Host Private Concert in Nashville 2
(Date:4/17/2015)... CAMBRIDGE, England , April 17, 2015 ... cancer genomics company announced today that their presence at the ... will include a presentation by co-founder Nitzan Rosenfeld ... is also attending April 18 th - 22 nd ... genome in plasma using ctDNA , forms part ...
(Date:4/17/2015)... , Apr. 17, 2015 Research and Markets ... of the "Medical Equipment Rental and Leasing - ... This report analyzes the worldwide markets for ... report provides separate comprehensive analytics for the US, ... and Rest of World. Annual estimates and ...
(Date:4/17/2015)... , April 17, 2015  Trovagene, Inc., ... announced today that clinical data presented at the ... its urine-based Precision Cancer Monitoring ℠ (PCM) ... monitoring of EGFR T790M mutations in ... Detection of EGFR T790M Mutation in Urinary Circulating ...
Breaking Medicine Technology:Inivata Co-founder Nitzan Rosenfeld to Present at AACR Annual Meeting 2Medical Equipment Rental and Leasing Market 2015-2020 - Global Strategic Business Report - Healthcare Spending Slowdown Bodes Well for Medical Equipment Leasing 2Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 2Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 3Trovagene's Urinary ctDNA Assay Outperforms Tissue Biopsy in Clinical Study for the Detection of EGFR T790M Mutations in Metastatic Lung Cancer Patients 4
... (Nasdaq: CPHD ) today announced that ... investor conferences, and invited investors to participate via ... 15, 2010 at 10.30 a.m. Eastern TimeStifel Nicolaus ... 10.55 a.m. Eastern TimeUBS Global Life Sciences Conference, ...
... Reportlinker.com announces that a new market research report ... Diagnostic Imaging Market to 2016 - Nuclear Imaging ... Revenue Generators http://www.reportlinker.com/p0286302/Diagnostic-Imaging-Market-to-2016---Nuclear-Imaging-Systems-and-Ultrasound-Systems-to-be-the-Key-Revenue-Generators.html ... - Nuclear Imaging Systems and Ultrasound Systems to ...
Cached Medicine Technology:Cepheid to Webcast Upcoming Financial Presentations 2Reportlinker Adds Diagnostic Imaging Market to 2016 - Nuclear Imaging Systems and Ultrasound Systems to be the Key Revenue Generators 2Reportlinker Adds Diagnostic Imaging Market to 2016 - Nuclear Imaging Systems and Ultrasound Systems to be the Key Revenue Generators 3Reportlinker Adds Diagnostic Imaging Market to 2016 - Nuclear Imaging Systems and Ultrasound Systems to be the Key Revenue Generators 4Reportlinker Adds Diagnostic Imaging Market to 2016 - Nuclear Imaging Systems and Ultrasound Systems to be the Key Revenue Generators 5Reportlinker Adds Diagnostic Imaging Market to 2016 - Nuclear Imaging Systems and Ultrasound Systems to be the Key Revenue Generators 6Reportlinker Adds Diagnostic Imaging Market to 2016 - Nuclear Imaging Systems and Ultrasound Systems to be the Key Revenue Generators 7Reportlinker Adds Diagnostic Imaging Market to 2016 - Nuclear Imaging Systems and Ultrasound Systems to be the Key Revenue Generators 8Reportlinker Adds Diagnostic Imaging Market to 2016 - Nuclear Imaging Systems and Ultrasound Systems to be the Key Revenue Generators 9Reportlinker Adds Diagnostic Imaging Market to 2016 - Nuclear Imaging Systems and Ultrasound Systems to be the Key Revenue Generators 10Reportlinker Adds Diagnostic Imaging Market to 2016 - Nuclear Imaging Systems and Ultrasound Systems to be the Key Revenue Generators 11Reportlinker Adds Diagnostic Imaging Market to 2016 - Nuclear Imaging Systems and Ultrasound Systems to be the Key Revenue Generators 12Reportlinker Adds Diagnostic Imaging Market to 2016 - Nuclear Imaging Systems and Ultrasound Systems to be the Key Revenue Generators 13
... Ultra MD Super Pulse sealed CO2 ... versatility backed by the experience and support ... years of surgical laser experience. All settings ... finger. The Ultra MD Super Pulse surgical ...
The compact size and portability of the Epic system makes it a cost-effective solution for single or multi-office use....
A soft contact lens that lets presbyopes see clearly and comfortably at all distances , without the hassles of bifocals or reading glasses. Recommended for daily wear. Also approved for extended wear...
... display of corneal layers: endothelium, ... epithelial layers. Accurate analysis of ... keratocytes, nerve fibres, basal & ... surgery and pathology: optical pachymetry, ...
Medicine Products: