Navigation Links
New risk factor for developing breast cancer
Date:11/10/2010

An Australian research team from the Peter MacCallum Cancer Centre, the University of Melbourne and the University of Queensland has identified a new risk factor for developing breast cancer. This has been published online in the journal Cancer Prevention Research.

The risk factor involves a modification (DNA methylation) to the BRCA1 gene. BRCA1 is known for its involvement in breast and ovarian cancer. Women with mutations in this gene, which inactivates its function, are predisposed to these diseases.

The DNA methylation modification is known as an epimutation and acts to turn off the BRCA1 gene from its normal protective function against breast cancer. It is not considered a genetic mutation as it does not directly affect the sequence of the gene like a mutation but nevertheless inactivates the normal protective function of the gene.

The study involved women diagnosed with breast cancer before the age of 40 years for whom BRCA1 mutations had not been identified. The epimutation was found in the blood of some women with breast cancer, especially those who develop the same type of breast cancer that develops in women with a BRCA1 mutation. However, unlike mutations in the BRCA1 gene, these epimutations appear not to be inherited and the relatives of women with epimutations are not at increased risk of breast or ovarian cancer.

Professor Melissa Southey from the University of Melbourne Department of Pathology, co-leader of the Australian Breast Cancer Family Study and a senior author on the paper said factors that triggered epimutations that stopped the gene BRCA1 from doing its usual job of preventing breast cancer might cause the same proportion of early-onset breast cancers (10%) as do inherited faults in this gene.

"For about 3-4% of young women, their BRCA1 gene has been made less capable of preventing breast cancers by some unknown factors. This places them at a 3.5-fold increased risk of breast ca
'/>"/>

Contact: Rebecca Scott
rebeccas@unimelb.edu.au
61-383-440-181
University of Melbourne
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Growth factor regenerates tooth supporting structures: Results of a large randomized clinical trial
2. Taking the fear factor out of cancer
3. Fox Chase researchers identify risk factors for the spread of breast cancer to lymph nodes
4. Childhood stroke study identifies the contraceptive pill and smoking as risk factors
5. Study identifies 5 risk factors for late-stage head and neck cancer
6. UC San Diego researchers identify factor boosting leukemias aggressiveness
7. Hospital readmission studies: Influencing factors identified
8. Lifestyle intervention improves risk factors in type 2 diabetes
9. MSU researcher awarded $14 million to identify breast cancer risk factors
10. Molecular playbook for halting heart failure risk factor uncovered
11. Genetic factor in osteoporosis discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... Hastings and Hastings, a law firm in Arizona ... of legal representation client review requests for slip and fall ... rise in the number of slip and fall related accidents ... Valley. With that said, a large number of injury victims ... law firm. Hastings and Hastings is a personal injury firm ...
(Date:1/22/2015)... LunaDress, with its top dressmaking technologies, has been a ... is showing its latest designs of wedding dresses and launching ... company’s CEO, all the fresh new products are designed for ... to 80% off. All the clothes from LunaDress follow up ...
(Date:1/22/2015)... 22, 2015 Padre Murphy's and Owner Tom ... Pro Player Health Alliance (PPHA). The PPHA's passion ... getting everyone, including NFL greats, treated for obstructive sleep apnea ... groups supporting the cause in the valley. The most recent ...
(Date:1/22/2015)... Blue Cross and Blue Shield of Minnesota (Blue Cross) wants ... “Live Fearless.” , The “Faces of Fearless” campaign ... how they or someone they know has faced a challenge, ... moment. By telling these types of stories through livefearlessmn.com, participants ...
(Date:1/22/2015)... A new white paper by The Beryl ... the long-term care environment as well as provides recommendations ... paper, “The Power of Person-Centeredness in Long-Term Care: A ... the patient, resident and family experience in long-term care ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Reports a Record Number of Client Review Requests for Slip and Fall Accidents in 2014 2Health News:LunaDress Shows The Latest Styles Of Wedding Dresses In 2015 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 2Health News:The Power of Person-Centeredness in Long-Term Care Explored by The Beryl Institute 3
... guidelines for the treatment of exacerbations in cystic fibrosis ... clinical practices. "This is the first such comprehensive ... exacerbation of cystic fibrosis," said Susanna McColley, M.D., head ... the Cystic Fibrosis Center at Children,s Memorial Hospital and ...
... surprising reversal of long-standing scientific belief, researchers at the Mayo ... brain is not the trigger that leads to buildup of ... inflammation helps clear the brain of these noxious amyloid plaques ... mice that are predisposed to the disorder, say the researchers ...
... prescriptions issued by GPs has been caused by a year ... drugs on a long-term basis, according to researchers from the ... printed edition of British Medical Journal ( BMJ ... number of new patients diagnosed with depression over 11 years, ...
... discard stored embryos, studies show , THURSDAY, Oct. 22 ... playing a key role in many couples, decisions about ... using assisted reproductive technology or whether they will discard ... , Among the new findings, presented this week at ...
... exposing healthy kids to those already sick with the H1N1 flu ... are doing all they can to avoid the swine flu, some ... , These are parents who are reportedly arranging swine flu "parties" ... healthy children can be exposed to the virus through kids who ...
... worldwide study could one day lead to new treatments ... worldwide study has clinched the case that the gene ... involved in Parkinson,s disease. , "For those of us ... come up with insights that are applicable to more ...
Cached Medicine News:Health News:New clinical guidelines for exacerbations in cystic fibrosis 2Health News:Manipulating brain inflammation may help clear brain of amyloid plaques, Mayo Clinic researchers say 2Health News:Manipulating brain inflammation may help clear brain of amyloid plaques, Mayo Clinic researchers say 3Health News:Money Woes Keeping Many Couples From Fertility Treatments 2Health News:Money Woes Keeping Many Couples From Fertility Treatments 3Health News:Swine Flu Parties? Send Your Regrets, Experts Say 2Health News:Gene Behind Gaucher Disease a Player in Parkinson's 2Health News:Gene Behind Gaucher Disease a Player in Parkinson's 3
(Date:1/23/2015)... , Jan. 23, 2015   Leatt Corporation  (OTCQB: ... protective equipment for all forms of sports, including extreme ... neck brace, announced today that the UISP Lega Motociclismo ... requires all riders to wear a neck brace during ...
(Date:1/23/2015)... 23, 2015  Mallinckrodt plc (NYSE: MNK ) ... a share repurchase program. The open-ended authorization permits the ... plc ordinary shares. "Funding additional initiatives ... as we continue to pursue a range of focused ...
(Date:1/23/2015)... and BOSTON , January 23, 2015 ... discovery and development company, is delighted to announce that the ... awarded to Miles Congreve (Vice President of Chemistry), ... Malcolm Weir (Chief Executive Officer and co-founder) for ...
Breaking Medicine Technology:Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3Mallinckrodt plc Announces Share Repurchase Program 2Mallinckrodt plc Announces Share Repurchase Program 3Mallinckrodt plc Announces Share Repurchase Program 4Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 2Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 3Heptares Scientists to Receive the Malcolm Campbell Memorial Prize for 2015 in Recognition of Their Outstanding Contribution to GPCR Drug Discovery 4
... HILL, N.C., March 30, 2012  The launch landscape for ... and payer influence two of the biggest changes facing ... successful new products has never been greater with the ... development costs. In this challenging new launch ...
... PHILADELPHIA, Pennsylvania, March 30, 2012 Shire plc ... biopharmaceutical company, today announced top-line results of the PREVENT2 trial, ... mesalamine in patients with a history of diverticulitis. [ ... countries worldwide including the United States, did not meet the ...
Cached Medicine Technology:Excellence Services Program Helps Guide Pharmaceutical Industry Through the New Product Launch Landscape 2Shire Announces Top-line Results of the PREVENT2 Trial 2Shire Announces Top-line Results of the PREVENT2 Trial 3Shire Announces Top-line Results of the PREVENT2 Trial 4Shire Announces Top-line Results of the PREVENT2 Trial 5
Bravo Tubing/Filter Supplies (Ten tubing sets, ten filters)...
... The lower esophhageal sphincter ... without using a separate manometry ... Locator, LES identification accessory kit ... used to locate the LES. ...
Buffer solution is needed to calibrate pH catheters. The specific chloride ion concentration in the Medtronic buffers is required for proper function of your Medtronic pH measurement system. Buffer s...
The WaveMax is one of the most flexible stainless steel stents due to its unique wave design and has the lowest effective profile, accommodating a 6F sheath up to 7 mm....
Medicine Products: