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New review suggests caution on drugs to raise 'good' cholesterol
Date:8/14/2007

epression.

Im much more excited about the prospect of whats coming in this area in the next three to five years, said Shah, who is studying approaches to boosting HDL that use different mechanisms from those that have been associated with problems. Clinical trials of a gene therapy based on his research are currently under way.

Despite the recent negative HDL trials, this field is extremely exciting and the pace of discovery is unbelievably fast, Shishehbor said. At least one other drug with a novel mechanism of action is also in trials and at least three other approaches have led to new drugs in the pipeline.

People with blood levels of HDL lower than 35 mg/dL have eight times the risk of heart disease compared to those with 65mg/dL or more. Some 16 percent to 18 percent of men have low levels, compared with 3 percent to 6 percent of women.


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Contact: Lisa Esposito
hbns-editor@cfah.org
Center for the Advancement of Health
Source:Eurekalert

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