Navigation Links
New research suggests hearts are experts at self-preservation
Date:9/30/2007

Bristol researchers have identified a heart protection mechanism in mice that surgeons and cardiologists may be able to exploit to improve treatments for patients in future.

The research, published in the October issue of the American journal Critical Care Medicine, was funded by the British Heart Foundation and conducted by Saadeh Suleiman, Professor of Cardiac Physiology at the University of Bristol, and his colleagues at the Bristol Heart Institute. It describes surprising responses of the heart to mock cardiac surgery in a mouse model. When the heart was stopped and restarted - mimicking the conditions used in most heart bypass surgery - scientists found that hearts with coronary disease from genetically modified mice were more resistant to damage than hearts without coronary disease.

In the study the researchers have introduced a model of coronary artery disease and heart attack by feeding the genetically modified mice (apoE-/-) a high-fat diet typical of people's diets in North America and the UK. Apo E-/- mice fed a normal rodent diet for the same period do not develop coronary disease. The genetic modification in apoE-/- involves changing cholesterol processing, making the mouse prone to fatty build-up in the coronary arteries, similar to human heart disease.

In apoE-/- mice, coronary disease seemed to have 'preconditioned' the hearts; they had developed an innate protection against further damage.

This confirms a widely held belief that in certain patients who have survived a heart attack, the heart may become naturally preconditioned against further damage, and that when treating patients with coronary disease, surgeons and cardiologists have an advantage that can be further exploited to protect the heart. The team at the Bristol Heart Institute, based in the Bristol Royal Infirmary, is currently using this model to investigate the basis of this internal protective phenomenon in order to formulate strategies to protect hearts with coronary disease.

An exciting observation was also made when normal mice were fed the same Western-type high-fat diet. These mice do not develop coronary disease and their hearts appear to function normally. However, when hearts from these mice were starved of blood supply such as in a heart attack or during surgery - they were found to be much more vulnerable to injury than hearts of similar mice fed normal diet. This is in complete contrast to the disease-prone animals and suggests that Western style high-fat diet can significantly weaken the internal defences of the otherwise normally working heart and render it vulnerable to any sudden stress. Therefore the Western-style diet is truly ugly for disease prone hearts and it is also bad for healthy hearts.

Professor Suleiman, said: "We have shown that in mice prone to developing coronary artery disease, a Western-style diet accelerates the progression of disease but that hearts with coronary disease then became more resistant to further damage, such as occurs during surgery. But it is still better to avoid surgery altogether by adopting healthy eating habits!"


'/>"/>

Contact: Joanne Fryer
joanne.fryer@bristol.ac.uk
44-117-331-7276
University of Bristol
Source:Eurekalert

Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Stem cell research- now Nobel Laureates join the debate
3. Researchers urge caution in using ear tube surgery
4. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
5. Spouses and other partners lower blood pressure says new research
6. Researchers Scale to assess the Severity of Epilepsy in Kids
7. More Research Required For COPD
8. Researchers identify the early makers of Neonatal Sepsis
9. OHSU Researchers Announce New Discovery
10. Skin Cancer Research To Go Global
11. Researchers Identify Gene Connected To Bipolar Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
(Date:6/24/2016)... Angeles, CA (PRWEB) , ... June 24, 2016 , ... ... surgery procedures that most people are unfamiliar with. The article goes on to state ... procedures, but also many of these less common operations such as calf and cheek ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda ... orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including ... accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening ... Talker Award, an essay contest in which patients and their families pay tribute to ... at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Bracket , ... launch its next generation clinical outcomes platform, Bracket eCOA (SM) ... held on June 26 – 30, 2016 in ... first electronic Clinical Outcome Assessment product of its kind to ... #715. Bracket eCOA 6.0 is a flexible platform ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 ... Tomorrow,s Leaders Scholarship is any indication, the future is ... online at www.diabetesscholars.org by the Diabetes Scholars ... in the way of academic and community service excellence. ... program since 2012, and continues to advocate for people ...
(Date:6/23/2016)... 2016 Revolutionary technology includes multi-speaker ... , industry leaders in advanced audiology and hearing aid ... Opn ™, the world,s first internet connected hearing aid ... devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ) ... of ,world firsts,: , TwinLink™ - the ...
Breaking Medicine Technology: