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New research suggests cutting calories may improve response to cancer treatment
Date:8/21/2013

reduced the number of circulating lymphoma cells in the mice, suggesting that the combination sensitized the lymphoma cells to treatment.

To further test their observations, researchers conducted several additional laboratory-based analyses, confirming that the cancer-related activity of Mcl-1 had decreased. Next, researchers combined two calorie-restriction mimetics (chemical compounds known to mimic the activity of calorie restriction), 2-deoxy-glucose and lonidamine, with lymphoma cells from the mice and ABT-737 and examined their activity. The team observed that the combination of the calorie-restriction mimetics and ABT-737 successfully blocked the protein translation of Mcl-1, confirming their observations that calorie restriction had indeed led to decreased Mcl-1 expression and had sensitized lymphoma cells to treatment.

"The results of our investigation provide encouraging data that suggest that the combination of a defined period of calorie restriction and targeted therapy may have the potential to increase cancer survival," said Dr. Ricci. "This is just the beginning of our journey to bring these research findings to the clinical setting. We next want to examine what component of a reduced-calorie diet fats, sugars, or another food compound influenced the lymphoma cells' improved sensitivity to treatment."


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Contact: Amanda Szabo
aszabo@hematology.org
202-552-4914
American Society of Hematology
Source:Eurekalert

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