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New research suggests cutting calories may improve response to cancer treatment
Date:8/21/2013

(WASHINGTON, August 21, 2013) New research suggests that restricting calories for a defined period of time may improve the success of cancer treatment, offering valuable new data on how caloric intake may play a role in programmed cancer cell death and efficacy of targeted cancer therapies. Study results were published online today in Blood, the Journal of the American Society of Hematology (ASH).

While previous studies suggest a connection between caloric intake and the development of cancer, scientific evidence about the effect of caloric intake on the efficacy of cancer treatment has been rather limited to date. When humans and animals consume calories, the body metabolizes food to produce energy and assist in the building of proteins. When fewer calories are consumed, the amount of nutrients available to the body's cells is reduced, slowing the metabolic process and limiting the function of some proteins. These characteristics of calorie restriction have led researchers to hypothesize that reducing caloric intake could potentially help inhibit the overexpression of the protein Mcl-1, an alteration associated with several cancers.

"While we know that consuming excess calories is associated with increased cancer risk, far less clarity exists in the scientific literature about how calorie restriction and the body's metabolism can potentially affect the body's response to cancer treatment," said lead study author Jean-Ehrland Ricci, PhD, of the French Institute for Health and Medical Research in Nice, France. "By understanding the link between metabolism and the body's natural cancer suppressors and activators, we can perhaps improve the efficacy of therapy and improve survival for patients suffering from specif
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Contact: Amanda Szabo
aszabo@hematology.org
202-552-4914
American Society of Hematology
Source:Eurekalert

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