Navigation Links
New research strategy for understanding drug resistance in leukemia
Date:9/4/2009

ted the mouse model of AML through two key steps. First they utilized a strain of mice that had a single gene mutation closely resembling the mutation found in leukemia and some other cancers. Then they introduced an infectious particle called a retrovirus, which produces additional mutations that work together and result in AML. The retrovirus also "tags" these new genetic mutations, which allows researchers to identify them later on. These steps resulted in a model of AML that, like human AML and other advanced cancers, has several genetic mutations that interact with one another.

To assess the effectiveness of the MEK inhibitor, the researchers compared a group of mice with AML that was treated with the drug to a group that was left untreated and found that the drug increased survival time threefold. However, all of the leukemia cells that initially responded to the drug later relapsed, which is similar to what happens in many human patients.

"This shows that even if you make what seems to be a really good drug, resistance is a major problem that must be overcome," said Shannon, who is also a leader of the hematopoietic malignancies research program at UCSF's Helen Diller Family Comprehensive Cancer Center.

In the next phase of the study, the research team set out to uncover the genes that triggered drug resistance by comparing cells from the original drug responsive AML to those of the relapsed AML. Because AML in the mouse model had been created with a retrovirus, the new mutations that caused the leukemia to relapse could be pinpointed through forward genetic analyses. These analyses identified two new single gene mutations that rendered the MEK inhibitor ineffective and brought about the relapsed AML.

According to the researchers, this same method can be used to study other types of cancer in order to identify additional genes responsible for drug resistance. "The hope is that this new strategy will enable us to identify mo
'/>"/>

Contact: Kate Schoen
kschoen@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Explorys, the leader in big data-driven healthcare transformation, ... Yarrington as Vice President of Operations, Adam Wallace as ... President of Solutions. These new leaders are part of ... to support client demand for the company’s big data ... of its partner network. , Since the company ...
(Date:12/22/2014)... Give a loved one the greatest gift of ... vitality. , For a limited time, HealthiPlus ( https://healthiplus.com/christmas-gift-packages/ ... special Holiday Wellness gift packages at drastically reduced prices ... contains cutting-edge, proven nutritional support for joints, mental functioning ... we age. , Joint Health Plus contains ...
(Date:12/22/2014)... December 22, 2014 The MedTech industry is ... a wholly owned subsidiary of PartnerTech AB of Sweden, is ... recently achieved additional ISO Certification. , All signs point to ... and the likelihood of a repeal of the excise tax ... The industry is anticipating annual growth of 9.3% and PartnerTech ...
(Date:12/22/2014)... New York NY (PRWEB) December 22, 2014 ... reports that a federal panel of judges has granted ... lawsuits in the U.S. District Court, Eastern District ... (JPML) issued an order on December 12 to transfer ... actions–pending in 22 districts to the Louisiana court for ...
(Date:12/22/2014)... December 22, 2014 TheHardwareCity.com now stocks ... with many useful features. Customers of the large online ... the new gloves delivered to their home or workplace ... hand tools that incorporate heavy duty magnets, which make ... allows workers to store metal parts on the back ...
Breaking Medicine News(10 mins):Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 2Health News:Explorys Continues to Experience Rapid Growth, Adds Three Healthcare IT Executives to Its Leadership Team 3Health News:You Still Have Time to Give the Gift of Health and Vitality to a Mature Loved One 2Health News:PartnerTech Inc. Poised for Growth in MedTech 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 3Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 4Health News:MagnoGrip Pro Utility Magnetic Gloves on Sale at TheHardwareCity.com 2
... in the international research consortium named MetaHit, scientists from ... an individual,s intestinal bacteria flora, regardless of nationality, gender ... of intestinal bacteria flora is hypothesised to have an ... and medicine absorbed through the gastro-intestinal tract. The results ...
... , WEDNESDAY, April 20 (HealthDay News) -- Poor ... more likely than others to cut back on health ... to a new study. Conducted by the RAND ... earlier studies, which found that so-called "medically vulnerable" people ...
... Queen,s University professor Kate Harkness has found that a ... substantially increases the risk of depression in adolescence by ... Adolescents with a history of maltreatment and a mild ... of the stress hormone cortisol than is normal in ...
... Men are more likely to see issues in black-and-white, whereas women ... contends. British researchers asked 113 volunteers to judge how 50 ... The objects and categories were highly likely to stimulate debate or ... a tool? Men were found to be more likely to ...
... School of Medicine researcher has developed a potential ... prevalent sexually transmitted disease and the leading cause ... Ph.D., professor of immunology and microbiology, internal medicine ... demonstrated a vaccine effect to inoculate against Chlamydia ...
... of severe traumatic brain injury (TBI), the U.S. Department ... this type of injury receive adequate protein and calories ... weeks of treatment, says a new report from the ... severely brain-injured patients shows that providing energy and protein ...
Cached Medicine News:Health News:What's your intestinal bacteria type? 2Health News:High-Deductible Health Plans Bring Equal Savings to All: Study 2Health News:WSU files for patent on researcher's vaccine technology for chlamydia 2Health News:WSU files for patent on researcher's vaccine technology for chlamydia 3Health News:WSU files for patent on researcher's vaccine technology for chlamydia 4Health News:Protein and calories can help lessen effects of severe traumatic brain injury 2
(Date:12/19/2014)... YORK , Dec. 18, 2014 Somewhere ... addressing hearing health was forgotten. But Audicus , ... to hear better this new year. Hearing ... facing the aging population, though it is often unaddressed. ... in four has a hearing aid, mainly due to ...
(Date:12/19/2014)... , Dec. 18, 2014  Decision Resources Group finds ... United States will increase to a value ... primarily driven by expansion in the large direct energy ... will be increasingly adopted due to the advantages they ... Other key findings from Decision Resources Group,s coverage of ...
(Date:12/19/2014)... 2014 Baptist Health Lexington is the first facility ... full Atrial Fibrillation with Electrophysiology Services (EPS) Accreditation status from ... fibrillation is the most common cardiac arrhythmia and has become ... lead to stroke and possible death. More than 5 million ... atrial fibrillation and the numbers are rapidly increasing as the ...
Breaking Medicine Technology:Audicus Will Help People Resolve to Hear Better in 2015 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3
... WASHINGTON, Jan. 20, 2012  National Pharmaceutical Council (NPC) Chief Science ... "From Methods to Policy," in the new peer-reviewed, bimonthly publication, ... serves as an associate editor for the Journal . ... "the intended and unintended consequences of CER," as a way ...
... -- China Health Resource, Inc. (OTCBB: CHRI), announced today that ... a leading producer of Gastrodia in Pingwu, Sichuan.  This exclusive ... 2015, and extends the very successful product line for an ... March 31, 2012.  The quality of Gastrodia under this agreement ...
Cached Medicine Technology:National Pharmaceutical Council Debuts Column, "From Methods to Policy," In New Journal of Comparative Effectiveness Research 2China Health Resource Signs 3 Year Exclusive Agreement for Acquisition of Gastrodia Extending Very Successful Product Line Through 2015 2China Health Resource Signs 3 Year Exclusive Agreement for Acquisition of Gastrodia Extending Very Successful Product Line Through 2015 3
For the direct colorimetric determination of alkaline phosphatase in human serum....
Auto LDL-Cholesterol, automated analyzer test kits....
For the quantitative determination of uric acid in serum....
For the quantitative determination of uric acid in serum....
Medicine Products: