Navigation Links
New research shows versatility of amniotic fluid stem cells

WINSTON-SALEM, N.C. For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for treating a wider array of diseases and conditions than scientists originally thought.

Reporting in Oncogene, a publication of Nature Publishing Group, the research teams of Anthony Atala, M.D., director of the Wake Forest Institute for Regenerative Medicine, and Markus Hengstchlger, Ph.D., from the Medical University of Vienna, have shown that these amnion stem cells can form three-dimensional aggregates of cells known as embryoid bodies (EBs). It is believed that cells at this stage of development can be directed to become virtually any cell in the human body.

"This finding suggests that the amnion cells have greater potential than we originally thought and may be able to form many cell types," said Atala. "This could expand the number for diseases and conditions that they may be helpful for."

Atala's team is currently evaluating the cells for their potential to treat diabetes and kidney disease. They were the first to report success (Nature Biotechnology, Jan. 2007) in isolating stem cells from placenta and amniotic fluid, which surrounds the developing fetus. The current research is one of several projects designed to determine the potential of this new type of stem cell.

For the study, scientists generated two additional lines of stem cells from amniotic fluid using the same protocol developed by Atala's lab. They then investigated the incidence of EB formation in all three lines.

"Performing many independent experiments using different approaches, we demonstrate in the report that human amnion stem cells can indeed form embryoid bodies," write the researchers in Oncogene. "Amnion cells are on the way to become an important source for both basic science and regenerative medicine."

In addition to the finding about EBs, the scientists identified a protein found inside cells (mTOR) as the regulator of EB formation. Hengstshlger, whose team was the first to provide evidence for the existence of stem cells in amniotic fluid, said that this finding may allow for new insights into the molecular mechanism of EB formation.

He said the cells may be a useful source for generating disease-specific stem cell lines for studying the differentiation process to determine what goes wrong in genetic diseases.

"These stem cells allow for studying the effects of mutations causing human genetic diseases on specific cell differentiation processes," he said.

Other potential advantages of the cells are that they can be grown in large quantities and are readily available during gestation and at the time of birth. "Whether these cells are as versatile as embryonic stem cells remains to be determined," said Atala, "but the current finding is certainly encouraging."

Atala stopped short of calling the cells pluripotent, which means the ability to form many cell types. He said while the cells meet some of the characteristics of pluripotency, such as versatility, they do not form tumors when implanted in animals, which is also considered a characteristic. The fact that the amnion cells are less likely to form tumors may be one advantage that they have over embryonic stem cells in their potential for clinical use.


Contact: Karen Richardson
Wake Forest University Baptist Medical Center

Related medicine news :

1. Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps
2. Top 10 Food Tips for the Holidays from the National Foundation for Cancer Research
3. DKNY JEANS Launches Exclusive Collection With HSN for St. Jude Childrens Research Hospitals Thanks and Giving(R) Campaign
4. Researchers identify role of gene in tumor development, growth and progression
5. CVS/pharmacy Kicks Off Annual Thanks and Giving(R) Campaign for the St. Jude Childrens Research Hospital
6. Case Western School of Medicine receives RWJF grant to establish a public health research network
7. Immunology expert at Childrens Hospital receives APS prize for patient-oriented research
8. On the trail of a vaccine for Lyme disease: Yale researchers target tick saliva
9. Research indicates that babys sleep position is the major factor in flat-headedness
10. BIDMC scientists awarded grants from Michael J. Fox Foundation for Parkinsons research
11. Research Collaboration Focuses on Unfinished Business at the End of Life
Post Your Comments:
(Date:11/26/2015)... ... November 26, 2015 , ... Inevitably when people think ... customers choose to buy during the Black Friday and Cyber Monday massage chair ... to search the Internet high and low to find the best massage chair deals, ...
(Date:11/26/2015)... ... 26, 2015 , ... PRMA Plastic Surgery is updating their record books yet ... 6,000th free flap breast reconstruction surgery! , “What an accomplishment for the PRMA team, ... lives and it’s an honor to have served all of these women.” , PRMA ...
(Date:11/25/2015)... , ... November 25, 2015 , ... ... more aggressive than those found on mammography, according to a study published online ... additional cancers not seen on mammography may necessitate a change in treatment. , ...
(Date:11/25/2015)... ... November 25, 2015 , ... TyloHelo Inc , ... accessories. , Sauna accessories help improve the bather experience in the sauna, and ... styles for the purist looking for simplicity in design to accessories that encourage ...
(Date:11/25/2015)... ... November 25, 2015 , ... According to an ... is being more and more widely heralded as a breakthrough for performing hernia repairs. ... has over traditional laparoscopic surgery is that it can greatly reduce the pain that ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... of the "2016 Future Horizons and ... Abuse Testing Market: Supplier Shares, Country Segment ... to their offering. --> ... "2016 Future Horizons and Growth Strategies ...
(Date:11/26/2015)... PUNE, India , November 26, ... --> --> ... Research Report" and "Investigation Report on ... 2019 and 2021 forecasts data and ... library. . ...
(Date:11/26/2015)... November 26, 2015 ... addition of the  "2016 Future Horizons ... Cell Surface Marker Testing Market: Supplier ... to their offering.  --> ... of the  "2016 Future Horizons and ...
Breaking Medicine Technology: