Navigation Links
New research shows promise for possible HIV cure
Date:12/2/2013

CHICAGO Researchers have used radioimmunotherapy (RIT) to destroy remaining human immunodeficiency virus (HIV)-infected cells in the blood samples of patients treated with antiretroviral therapy, offering the promise of a strategy for curing HIV infection. Results of the study were presented today at the annual meeting of the Radiological Society of North America (RSNA).

Highly active antiretroviral therapy (HAART) has transformed the outlook for patients infected with HIV by suppressing the replication of the virus in the body. However, despite the success of HAART in effectively reducing the burden of HIV, scientists believe reservoirs of latently infected cells persist in the body, preventing the possibility of a permanent cure.

"In an HIV patient on HAART, drugs suppress viral replication, which means they keep the number of viral particles in a patient's bloodstream very low. However, HAART cannot kill the HIV-infected cells," said the study's lead author, Ekaterina Dadachova, Ph.D., professor of radiology, microbiology and immunology at Albert Einstein College of Medicine in the Bronx, N.Y. "Any strategy for curing HIV infection must include a method to eliminate viral-infected cells."

In her study, Dr. Dadachova and a team of researchers administered RIT to blood samples from 15 HIV patients treated with HAART at the Einstein-Montefiore Center for AIDS Research.

RIT, which has historically been employed to treat cancer, uses monoclonal antibodiescloned cells that are recruited by the immune system to identify and neutralize antigens. Antigens are foreign objects like bacteria and viruses that stimulate an immune response in the body. The antibody, designed to recognize and bind to a specific cell antigen, is paired with a radioactive isotope. When injected into the patient's bloodstream, the laboratory-developed antibody travels to the target cell where the radiation is then delivered.

"In RIT, the antibodies bind to the infected cells and kill them by radiation," Dr. Dadachova said. "When HAART and RIT are used together, they kill the virus and the infected cells, respectively."

For the study, Dr. Dadachova's team paired the monoclonal antibody (mAb2556) designed to target a protein expressed on the surface of HIV-infected cells with the radionuclide Bismuth-213.

The researchers found that RIT was able to kill HIV-infected lymphocytes previously treated with HAART, reducing the HIV infection in the blood samples to undetectable levels.

"The elimination of HIV-infected cells with RIT was profound and specific," Dr. Dadachova said. "The radionuclide we used delivered radiation only to HIV-infected cells without damaging nearby cells."

An important part of the study tested the ability of the radiolabeled antibody to reach HIV-infected cells in the brain and central nervous system. Using an in vitro human blood brain barrier model, the researchers demonstrated that radiolabeled mAb2556 could cross the blood brain barrier and kill HIV-infected cells without any overt damage to the barrier itself.

"Antiretroviral treatment only partially penetrates the blood brain barrier, which means that even if a patient is free of HIV systemically, the virus is still able to rage on in the brain, causing cognitive disorders and mental decline," Dr. Dadachova said. "Our study showed that RIT is able to kill HIV-infected cells both systemically and within the central nervous system."

According to Dr. Dadachova, clinical trials in HIV patients are the next step for the RIT treatment.


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert  

Related medicine news :

1. Researchers turn to machines to identify breast cancer type
2. Micromovements hold hidden information about severity of autism, researchers report
3. Human Resources Consulting Procurement Research Report Now Available from IBISWorld
4. Medical Dissertations Launches Research Paper Publication Support
5. Chanakya Research Offers Help with Law Dissertations
6. End-Year Discounts on Q1 2012 & Q4 2013 Research Publications by ABMRG Now Available at MarketPublishers.com
7. Nationwide Title Clearing, Inc. (NTC) Continues CSR Activities With Successful “Light the Night Walk”—Event Raised Over $77,000 for Cancer Research
8. BCC Research Publishes A New Report On Global Markets For Waste And Wastewater Treatment
9. Hemodialysis Industry for Global and China 2013 Analysis in New Research Report at ChinaMarketResearchReports.com
10. Cosmetic & Beauty Products Manufacturing in the US Industry Market Research Report from IBISWorld Has Been Updated
11. The Affordable Care Act: Translational research experiment to improve health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New research shows promise for possible HIV cure
(Date:6/25/2017)... (PRWEB) , ... June 24, 2017 , ... Create a feel-good lyric music video in ... footage and sound in the timeline and write in the lyrics to any song. ProLyric ... back out. Each line of the text can be added modularly for optimal control. ProLyric ...
(Date:6/25/2017)... ... , ... With a heatwave currently bearing down on Northern California pushing temperatures to the maximum, ... ready is easy with laser hair removal. , The process of summer waxing and ... when all you want to do is get out, dive in and cool off. There ...
(Date:6/24/2017)... ... June 24, 2017 , ... Dr. Mitchell Mehlman and ... in Lake Ronkonkoma, Dental365 offers patients high-quality and affordable routine and emergency dental ... dentist fit into their patients’ busy lifestyles. Dental365 also gladly work with most ...
(Date:6/23/2017)... Alexandria, VA (PRWEB) , ... June 23, 2017 ... ... short of what is needed and will ultimately do significant harm to people ... care to everyone. , "While it leaves in place the Affordable Care ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Military Officers Association of America (MOAA) ... of Veterans Affairs, retired Marine Col. Thomas G. Bowman. , Bowman currently serves as ... brings an intimacy with the issues and challenges veterans face with the VA. Following ...
Breaking Medicine News(10 mins):
(Date:6/7/2017)... 6, 2017  Diplomat Specialty Infusion Group, a brand of Diplomat ... its Iowa location. The ... now features an ISO 7 cleanroom—the standard needed to compound intravenous ... low level of pollutants. "Our ... and better serve our Iowa patients," said ...
(Date:6/1/2017)... , June 1, 2017 Nutriceutical Holdings (NH), ... Recommended Solutions (VRS), and KD Pharma Group have decided ... Holdings by KD Pharma Group. KD Pharma Group will ... option to acquire the entire company. "We ... They are committed to growing the NH companies by ...
(Date:5/26/2017)... DUBLIN , May 26, 2017  Endo International plc ... Campanelli , President and CEO, will represent the Company in ... Global Healthcare Conference on Tuesday, June 13, 2017 at 10:40 ... held at Terranea Resort in Rancho Palos Verdes, ... archive for the event will be available on the Company,s ...
Breaking Medicine Technology: