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New research shows genetic test for lung cancer risk prompts smokers to quit
Date:11/8/2010

said Dr Young. "The high rate of interest in taking Respiragene shows that smokers want to learn more about their own risk level, and for the vast majority, it helped them take positive steps to quit. These findings exceeded our expectations, especially as the participants in the study were randomly selected, and not specifically seeking support to quit smoking at the time of the study."

Young said he hoped the test, which personalizes risk for smoking-related diseases, would help lower smoking rates in the same way that measuring an individual's cholesterol and taking appropriate preventive steps to cut risk had brought a significant reduction in mortality from heart disease.

About the research

The study identified current smokers from a clinical database and randomly recruited 55 who completed a baseline questionnaire exploring their smoking habits and recent attempts to quit; 46 accepted the offer to take the test. Participants provided a simple cheek swab for DNA analysis and gave information about their family history of lung cancer and any previous diagnosis of Chronic Obstructive Pulmonary Disease (COPD). A week later smokers who underwent testing returned to the clinic for the result. The test estimates risk of lung cancer as moderate, high or very high based on DNA testing and non-genetic factors. Two follow-up interviews took place two weeks and six months after taking the Respiragene test, examining attitudes to the test and changes in smoking behavior. More than half of the smokers taking the risk test opted to use nicotine replacement products. U.S. Department of Health guidelines for doctors recommend nicotine replacement to help smokers quit; studies consistently show that smokers are much more likely to stop smoking if they are motivated and use medication.


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Contact: Ken Li
kli@chempetitive.com
312-532-4675
Chempetitive Group
Source:Eurekalert

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