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New research seeks to prevent preterm birth with March of Dimes support
Date:3/7/2014

riations and gene interactions to understand how they interact with a woman's environment to influence her risk of preterm birth.

  • Mala Mahendroo, PhD, of the University of Texas Southwestern Medical Center in Dallas, is working to understand cervical changes and how they trigger labor. She hopes to identify key steps in normal cervical ripening, as well as differences that may be caused by infection and other factors that trigger preterm labor.

  • Carole R. Mendelson, PhD, of The University of Texas Southwestern Medical Center in Dallas, is identifying proteins produced by the maturing fetal lungs that signal that the baby is ready to be born. A previous study found that one major lung protein, surfactant protein-A, acts as a hormonal signal that labor is beginning.

  • Stephen Lye, PhD, of the Mt. Sinai Hospital in Toronto, Ontario, is determining the effectiveness of probiotics as well as of a new class of drugs (broad spectrum chemokine inhibitors) in preventing inflammation and preterm birth associated with uterine infection. This research will build upon Dr. Lye's previous study that infection triggers inflammatory proteins that can help initiate uterine contractions.

  • Daniel Dufort, PhD, of McGill University in Montreal, is seeking to determine whether genetic mutations in a gene (Nodal) increase a woman's risk of preterm labor.


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  • Contact: Elizabeth Lynch
    elynch@marchofdimes.com
    914-997-4286
    March of Dimes Foundation
    Source:Eurekalert

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