Navigation Links
New research reinforces danger of drinking alcohol while pregnant
Date:2/14/2014

Women who drink alcohol at moderate or heavy levels in the early stages of their pregnancy might damage the growth and function of their placenta the organ responsible for supplying everything that a developing infant needs until birth - research at The University of Manchester shows.

Placentas studied in a laboratory environment showed that drinking alcohol at moderate (2/3 standard drinks) to high (4-6 standard drinks) rates reduced the cell growth in a woman's placenta.

The research, published in the journal PLoS One and funded by the British Medical Association, investigated the effect of alcohol and its major toxic breakdown product, acetaldehyde, had on the placenta in the first few weeks a period essential for normal development where three primary germ cell layers in the very early infant develop into internal organs. While placental cell growth was reduced at mid and heavy drinking levels, the cells that ensure the placenta attaches to the mother were unaffected. Alcohol at very low concentrations (1-2units, equal to half or one standard drink) did not have any effect on growth or function.

Scientists also found alcohol at moderate to heavy levels reduced the transport of an important amino acid known as taurine - from mother to baby via the placenta. Taurine is vital for brain and physiological development. However, acetaldehyde did not have any effect on the transportation of taurine suggesting alcohol is the main culprit. Reduced taurine has been shown to have negative effects on behaviour and physical development, so this might explain why some neurological symptoms are seen in children of alcoholic mothers, the researchers conclude.

Sylvia Lui, from the Tommy's Maternal and Fetal Health Research Centre based at The University of Manchester who carried out the research, said: "Alcohol and acetaldehyde are known to be toxic at high levels, but these results clearly show that levels easily achieved in a normal population have specific effects in the placenta.

"Placental growth is reduced in comparison to non-exposed placentas, suggesting that in the long-term, there could be consequences to how much support the infant receives from the placenta during the rest of the pregnancy after this exposure."

Dr Clare Tower, consultant obstetrician at Saint Mary's Hospital part of Central Manchester University Hospitals NHS Foundation Trust, said: "Though low levels of alcohol did not have a harmful effect, moderate to high levels were damaging. The safest clinical advice would be to agree with the current Royal College of Obstetrics and Gynaecology guidelines and abstain. This is because UK studies show that there is still a lot of confusion in the perception of what alcohol 'units' are, as well as a lack of accurate self-monitoring of drinking levels.

Professor John Aplin, Professor of Reproductive Biomedicine in the Tommy's Maternal and Fetal Health Research Centre at the University, said "This research also suggests that women who are trying to conceive should not drink as the damage caused by alcohol can happen very early on in pregnancy perhaps before a woman knows she is pregnant."

Jane Brewin, Chief Executive of baby charity Tommy's, said: "It can often be a few weeks before a woman discovers she's pregnant, and this research shows that moderate drinking during those vital first weeks can have a big impact on the development of the baby.

"Many pregnancies are unplanned, but for those actively planning a family this research raises questions about whether women should consider their alcohol intake even before they fall pregnant."


'/>"/>

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Related medicine news :

1. No such thing as porn addiction, researchers say
2. When is the right time to discuss delivery room research with parents?
3. Research!America honors Congressmen Frank Wolf and Chaka Fattah for advancing medical innovation
4. LA BioMed researchers report on promising new therapy for devastating genetic disorder
5. Bees fight to a stalemate in the battle of the sexes according to new research
6. NIH-funded researchers use antibody treatment to protect humanized mice from HIV
7. Researchers blend orthopedics, engineering to better repair torn rotator cuffs
8. University of Leeds to be a leader in data analytics and research
9. Researcher attacks pre-term labor problem
10. Fruit fly microRNA research at Rutgers-Camden offers clues to aging process
11. Research results show new way for cholesterol treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... ... to announce the integration of Microsoft(R) Word(TM) Online(TM), which enables sleep physicians to ... since it streamlines the reporting process and provides a familiar interface that does ...
(Date:4/28/2017)... York, NY (PRWEB) , ... April 28, 2017 ... ... Medical Laboratory to expanded distribution of the GlycoMark test throughout the Northeast U.S. ... recent hyperglycemia in patients with diabetes. The GlycoMark test provides a clinically proven ...
(Date:4/28/2017)... ... April 28, 2017 , ... Datta Endoscopic Back Surgery and ... revolutionary endoscopic practice under Dr. Datta. Patel is a Board Certified Anesthesiologist, with ... revolutionary eDiscSculpt Technique created and used by Datta Endoscopic is unlike traditional back ...
(Date:4/28/2017)... ... April 28, 2017 , ... Early detection ... improve drug safety and minimize the cost of development. In this webinar, sponsored ... using cell lines and for cardiac toxicity using induced pluripotent stem cells (iPSCs). ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... pilot study of ActiGraph’s CentrePoint Data Hub in a sample of ... of clinical-grade wearable activity and sleep monitoring solutions for the global scientific community. ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)... , April 18, 2017 Cogentix Medical, Inc. ... providing the Urology, Uro/Gyn and Gynecology markets with innovative ... first quarter ended March 31, 2017 after the market ... The Company will host a conference call and webcast ... Tuesday, May 2, 2017 at 4:30 p.m. Eastern Time ...
(Date:4/18/2017)... 18, 2017 Research and Markets has announced ... report to their offering. ... global arthroscopy devices market to grow at a CAGR of 6.35% ... Devices Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
(Date:4/18/2017)... SAN DIEGO and BLOOMINGTON, ... Pharmaceuticals, Inc. (NASDAQ: IMMY ) ("Imprimis"), ... d/b/a Precision Lens ("Precision Lens"), today announced the ... Under the agreement, Precision Lens will deploy a ... into select geographies in the U.S., primarily focused ...
Breaking Medicine Technology: