Navigation Links
New research reinforces danger of drinking alcohol while pregnant
Date:2/14/2014

Women who drink alcohol at moderate or heavy levels in the early stages of their pregnancy might damage the growth and function of their placenta the organ responsible for supplying everything that a developing infant needs until birth - research at The University of Manchester shows.

Placentas studied in a laboratory environment showed that drinking alcohol at moderate (2/3 standard drinks) to high (4-6 standard drinks) rates reduced the cell growth in a woman's placenta.

The research, published in the journal PLoS One and funded by the British Medical Association, investigated the effect of alcohol and its major toxic breakdown product, acetaldehyde, had on the placenta in the first few weeks a period essential for normal development where three primary germ cell layers in the very early infant develop into internal organs. While placental cell growth was reduced at mid and heavy drinking levels, the cells that ensure the placenta attaches to the mother were unaffected. Alcohol at very low concentrations (1-2units, equal to half or one standard drink) did not have any effect on growth or function.

Scientists also found alcohol at moderate to heavy levels reduced the transport of an important amino acid known as taurine - from mother to baby via the placenta. Taurine is vital for brain and physiological development. However, acetaldehyde did not have any effect on the transportation of taurine suggesting alcohol is the main culprit. Reduced taurine has been shown to have negative effects on behaviour and physical development, so this might explain why some neurological symptoms are seen in children of alcoholic mothers, the researchers conclude.

Sylvia Lui, from the Tommy's Maternal and Fetal Health Research Centre based at The University of Manchester who carried out the research, said: "Alcohol and acetaldehyde are known to be toxic at high levels, but these results clearly show that levels easily achieved in a normal population have specific effects in the placenta.

"Placental growth is reduced in comparison to non-exposed placentas, suggesting that in the long-term, there could be consequences to how much support the infant receives from the placenta during the rest of the pregnancy after this exposure."

Dr Clare Tower, consultant obstetrician at Saint Mary's Hospital part of Central Manchester University Hospitals NHS Foundation Trust, said: "Though low levels of alcohol did not have a harmful effect, moderate to high levels were damaging. The safest clinical advice would be to agree with the current Royal College of Obstetrics and Gynaecology guidelines and abstain. This is because UK studies show that there is still a lot of confusion in the perception of what alcohol 'units' are, as well as a lack of accurate self-monitoring of drinking levels.

Professor John Aplin, Professor of Reproductive Biomedicine in the Tommy's Maternal and Fetal Health Research Centre at the University, said "This research also suggests that women who are trying to conceive should not drink as the damage caused by alcohol can happen very early on in pregnancy perhaps before a woman knows she is pregnant."

Jane Brewin, Chief Executive of baby charity Tommy's, said: "It can often be a few weeks before a woman discovers she's pregnant, and this research shows that moderate drinking during those vital first weeks can have a big impact on the development of the baby.

"Many pregnancies are unplanned, but for those actively planning a family this research raises questions about whether women should consider their alcohol intake even before they fall pregnant."


'/>"/>

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Related medicine news :

1. No such thing as porn addiction, researchers say
2. When is the right time to discuss delivery room research with parents?
3. Research!America honors Congressmen Frank Wolf and Chaka Fattah for advancing medical innovation
4. LA BioMed researchers report on promising new therapy for devastating genetic disorder
5. Bees fight to a stalemate in the battle of the sexes according to new research
6. NIH-funded researchers use antibody treatment to protect humanized mice from HIV
7. Researchers blend orthopedics, engineering to better repair torn rotator cuffs
8. University of Leeds to be a leader in data analytics and research
9. Researcher attacks pre-term labor problem
10. Fruit fly microRNA research at Rutgers-Camden offers clues to aging process
11. Research results show new way for cholesterol treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... January 20, 2017 , ... "TransFlare 4K Mystique comes with 44 colorful ... Pro X," said Christina Austin - CEO of Pixel Film Studios. , TransFlare ... Sensor,TransFlare 4K Mystique lens flare and light leak transitions have a very high-dynamic range ...
(Date:1/20/2017)... , ... January 20, 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following ... Chocolate Biscuit” is the creation of published author, Marlyn Ivey, born in Lynn Haven, Florida ... went to school and at 19 years of age, he joined the Navy and got ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... “Journey to Christmas:” a beautiful and enchanting ... of published author, Kimberly Cordoves, a mother of three in Oklahoma City, and a devoted ... idea of writing a book has been in the back of my mind for years, ...
(Date:1/19/2017)... ... ... Today, the Centers for Medicare & Medicaid Services (CMS) announced over 359,000 ... in 2017. Clinicians who participate in APMs are paid for the quality of care ... effort to build a system that delivers better care and one in which clinicians ...
(Date:1/19/2017)... ... ... cold weather here, many people will have to clear snow with snow blowers or shovels ... but they can be dangerous when used incorrectly. That’s why Amica Insurance is ... of snow blowers:, , When removing wet snow or debris from ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... -- Shire plc (LSE: SHP, NASDAQ: ... Drug Administration (FDA) has acknowledged receipt of the Class ... SHP465, a long-acting, triple-bead, mixed amphetamine salts formulation. SHP465 ... Attention-Deficit/Hyperactivity Disorder (ADHD). The FDA is expected to provide ... designated Prescription Drug User Fee Act (PDUFA) action date. ...
(Date:1/19/2017)... January 19, 2017 New ... to Address Motor Symptoms and Motor Complications in ... ...      (Logo: http://photos.prnewswire.com/prnh/20151014/276718LOGO) C ... European Neurological Review,2016;11(Suppl. 2): 2-15, http://www.touchneurology.com/articles/safinamide-new-therapeutic-option-address-motor-symptoms-and-motor-complications-mid-late ...
(Date:1/19/2017)... NEW YORK , January 18, 2017 , , ... rd distribution agreement, following similar agreements ...   , Wound care is $2 5 ...   , E-QURE Corp. (OTCQB: EQUR), a leader in medical devices ... agreement with Tech - Médica Equipos Médicos S.A.S. (TeckMedica) in Colombia ...
Breaking Medicine Technology: