Navigation Links
New research provides new insight into age-related muscle decline
Date:9/22/2009

If you think the air outside is polluted, a new research report in the September 2009 issue of the journal Genetics (http://www.genetics.org) might make you to think twice about the air inside our bodies too. That's because researchers show how about 3 percent of the air we breathe gets converted into harmful superoxides, which ultimately harm our muscles. Specifically, these superoxides lead to the creation of a toxic molecule called "reactive oxygen species" or ROS, which is shown to be particularly harmful to muscle tissue, and may lead to problems ranging from aging and frailty to Parkinson's disease and cancer.

"At a minimum, we hope this research leads to new ways of addressing inevitable declining physical performance and other age-dependent infirmities among the elderly," said Atanu Duttaroy, associate professor of biology at Howard University in Washington, D.C. and one of the researchers involved in the work.

To make their discovery, Duttaroy and colleagues built on their previous research showing that ROS-induced cellular damage happens in the same way in fruit flies and in mice. They started with fruit flies that lack mitochondrial superoxide dismutase enzyme (SOD), which provides the primary line of defense against ROS by capturing the superoxides and converting them to water. This lack of SOD caused the fruit flies to die within a day after hatching. Then, through genetic manipulation, the researchers "turned on" the production of SOD separately in nerves and muscles. SOD in nerves did not appear to make a significant difference in prolonging the fruit flies' lives, but it did make a difference when it was activated in their muscles. The survival of fruit flies with SOD "turned on" in their muscles increased, and for several days, they remained as active as their normal counterparts. Measurement of their muscle activity also showed that SOD helped the muscle work normally, helping survival.

"It's long been known that the oxygen we breath can be toxic, and this work provides a concrete example of that with real consequences." said Mark Johnston, Editor-in-Chief of the journal Genetics. "As baby boomers get older, the need to help older people stay mobile and fit has never been greater in our lifetimes. This study helps address this need by providing insight into what causes physical decline, and in turn, bringing us a step closer toward finding ways to stop or reverse it."


'/>"/>

Contact: Tracey DePellegrin Connelly
td2p@andrew.cmu.edu
412-268-1812
Genetics Society of America
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... ... , ... Serenity Recovery, a substance abuse treatment center located in Central Michigan ... on one of the more popular of their optional courses, the Yoga Class. With ... patients and the Yoga class instructor, this video is available for viewing on the ...
(Date:4/30/2016)... ... April 30, 2016 , ... Dr. Trevor Gardner, President ... today signed a multifaceted agreement which will allow for the research and development ... of Natural and Applied Sciences, Allied Health and Nursing will work together to ...
(Date:4/29/2016)... Dobbs Ferry, New York (PRWEB) , ... April 30, 2016 , ... ... and the Dobbs Ferry campus. The following programs will be expanding due to ... Resources Management (HRM). The expansion will begin this summer. , School ...
(Date:4/29/2016)... ... April 29, 2016 , ... Our bodies are bombarded daily by ... and deal with these stressors is to adopt a more healthful diet, but too ... Risa Groux, a certified Holistic Nutritionist and the creator of the Newport Beach Cleanse ...
(Date:4/29/2016)... ... April 29, 2016 , ... Conditions were ideal for Global Lyme ... on Sunday, with sunny skies, a light breeze and temperatures in the 60s. Over ... The 5k Run and Walk and 1-mile walk were held to increase awareness ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016 New market research ... a report that provides an overview of the ... by identifying new targets and MOAs to produce ... discussed in this H1 2016 Osteoarthritis Pipeline report ... Inc., Abiogen Pharma S.p.A., Ablynx NV, Achelios Therapeutics, ...
(Date:4/27/2016)... 27, 2016 Elekta today announced ... will be the focal point of seven scientific presentations ... Society for Radiotherapy & Oncology, taking place April 29 ... state-of-the-art radiotherapy system and a high-field MRI scanner with ... the patient,s anatomy in real time. The MR-linac is ...
(Date:4/27/2016)... Massachusetts , April 27, 2016 ... that Jeff Poulton , Chief Financial Officer, will present ... Boston, MA on Wednesday, May 04, ... audio webcast will be available on the Presentations and Webcasts ... a replay of the webcast will be available on this ...
Breaking Medicine Technology: