Navigation Links
New research project aims to improve cancer therapies using type I interferons
Date:4/23/2013

The immune system plays a decisive role in the fight against tumor cells. However, when tumor cells themselves prevent activation of the immune system, the immune system fails to destroy cancer cells. The cancer drug interferon-α could probably neutralize this blockade. This cytokine is being used successfully to treat various forms of cancer. However, some patients experience undesirable autoimmune reactions on administration of the drug. The German Cancer Aid (Deutsche Krebshilfe e.V.) is donating EUR 180,000 to fund a research project at the University Medical Center of Johannes Gutenberg University Mainz that is to identify mechanisms underlying the effects of the cancer drug interferon-α (IFN-α) when it comes to fighting cancer cells by means of the blockade of so-called immunological tolerance processes. In addition, the researchers want to discover novel approaches to increase the efficacy of type I interferons in the treatment of cancer.

Interferon-α can trigger autoimmune reactions in patients, i.e., pathological reactions of the immune system. Interferon-α has been seen to date as an active substance that boosts the immune system and fights tumor cells directly. It is used, for example, in the therapy of malignant melanomas, certain forms of leukemia and cutaneous T-cell lymphomas. "The immune system is usually able to effectively destroy cancer cells. At the same time, however, there are also so-called tumor-associated tolerance processes that protect the tumor cells from being destroyed by the immune system. Autoimmune reactions, which are known side effects of therapies with IFN-α, may indicate that this anti-tumor treatment blocks tolerance mechanisms and thus improves the immune system's natural ability for tumor rejection," explained Professor Dr. Kerstin Steinbrink, senior physician at the Department of Dermatology of the Mainz University Medical Center, which is supervising the research project "Analysis of the Effect of Type I Interferons on Immunological Tolerance Processes" funded by the German Cancer Aid. The purpose of this project is to analyze the effects of IFN-α and other type I interferons on various immune cells that exhibit tolerogenic potential in vitro and also in melanoma patients.

The knowledge gained through this project should contribute to the development of improved therapy strategies for overcoming tolerance mechanisms associated with tumors. An additional objective is to enhance the efficacy of therapy with type I interferons. Steinbrink's research team is looking to reduce potential side effects as much as possible.

"This research project is taking a patient-oriented approach. The research team led by Professor Dr. Kerstin Steinbrink will profit from its expertise in the area of immunological tolerance that it has gained over several years," said Professor Dr. Ulrich Frstermann, Chief Scientific Officer of the Mainz University Medical Center.


'/>"/>

Contact: Dr. Reneé Dillinger-Reiter
pr@unimedizin-mainz.de
49-613-117-7424
Johannes Gutenberg Universitaet Mainz
Source:Eurekalert

Related medicine news :

1. Should kids sit less or move more? CHEO Research answers
2. The Melanoma Research Alliance Foundation supports CNIO research
3. Deficiency in p53 anti-tumor protein delays DNA repair after radiation, Moffitt researchers say
4. Latest research shows 2 items are key to decrease symptoms and prolong survival for LMC patients
5. Wayne State researchers seek calcium channels to target cancer tumors
6. Medical Device Market: Peru & Philippines New Market Research Report Available At Researchmoz.us
7. Toothpaste and Toothbrush Manufacturing in China Industry Research Report – Now Available from IBISWorld
8. Medical Robotic Systems Market - New Market Research Report Published by Transparency Market Research
9. Sickle cell project named among Top 10 Clinical Research Achievements for 2012
10. Feinstein Institute Researcher provides insight into osteoarthritis
11. Cleveland Clinic Childrens Hospital research suggests transmission of respiratory viruses in utero
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... MIAMI, FLA (PRWEB) , ... February 12, 2016 , ... ... free dental implants to their Miami dental office. Beginning in January, Miami Dental ... traditional titanium. Miami Dental Specialists are the first office to be chosen by the ...
(Date:2/12/2016)... ... February 12, 2016 , ... Mediaplanet today ... , The print component of “Revolutionizing Cancer Care” is distributed within the February ... and Seattle, with a circulation of approximately 250,000 copies and an estimated readership ...
(Date:2/12/2016)... ... February 12, 2016 , ... Homeowners now have ... possibilities. CertainTeed, North America’s leading brand of building products, has improved upon its ... in the mobile version of the ColorView® Exterior Style and Color Selector. Created ...
(Date:2/12/2016)... ... 12, 2016 , ... Healthcare careers in the medical laboratory, nursing, and in ... website of healthcare staffing leader Aureus Medical Group during the month of January. Aureus ... therapy positions and in travel and direct hire opportunities in other allied health ...
(Date:2/12/2016)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, Texas, ... real facts surrounding all those Bible stories. For generations families have gathered to hear ... says there is more to these than just mere “stories”. , The article ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 2016 Stem cells are primitive cells found ... and the capacity to differentiate into mature cell types ... the first mouse embryonic stem cells were derived from ... that the first culturing of embryonic stem cells from ... produced until 2006 As a result of these discoveries, ...
(Date:2/11/2016)... 11, 2016  Kindred Biosciences, Inc. (NASDAQ: KIN ... the lives of pets, today announced the submission to ... Animal Drug Application (NADA) for Zimeta™ (dipyrone injection, KIND-012).  ... of Zimeta for the control of pyrexia (fever) in ... --> --> The Chemistry, Manufacturing, ...
(Date:2/11/2016)... , Feb. 11, 2016   Health 2.0 ... of new health technologies, announced today " 10 Year ... in health tech over the past ten years.   ... nearly a decade, Health 2.0 has served as the ... and connected with thousands of technologies, companies, innovators, and ...
Breaking Medicine Technology: