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New research on type 2 diabetes could benefit young adults with the condition
Date:2/1/2010

New research on Type 2 diabetes by Trinity College Dublin researchers could benefit young adults (aged 18-25 years) with the condition. The research led by Professor John Nolan of Trinity College Dublin and St James's Hospital, Dublin, has just been published online in the leading international journal, Diabetes Care.

The study findings demonstrate new mechanisms in muscle cells that may explain severe insulin resistance which is the body's decreased ability to respond to the effects of insulin, and a reduced response to aerobic exercise in young obese patients with Type 2 diabetes. These important findings will contribute in the longterm to the development of more specific treatments for young people with Type 2 diabetes.

Type 2 diabetes is the most common form of diabetes. It occurs because the body produces too little insulin and is unable to properly use the insulin that is secreted. It usually occurs in older people although it is becoming more common among younger people, partly due to lifestyle factors such as diet, lack of physical activity and obesity. The highest rates occur in countries with modern lifestyles. Type 2 diabetes accounts for approximately 85%-90% of all cases of diabetes in European countries.

Commenting on the significance of the research, Professor John Nolan of the Department of Clinical Medicine, TCD, who led the Metabolic Research Group, said: "Type 2 diabetes is presenting in much younger people, usually because of early onset obesity and a strong family background of diabetes. These studies provide us with important new insights into the way diabetes develops and progresses in these young patients. In this study, we have shown that obese young patients with Type 2 diabetes, in contrast to equally obese young people without diabetes, have abnormal function of key mitochondrial genes and proteins. Mitochondria are the energy centres in cells and these abnormalities contribute to insulin r
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Contact: Caoimhe Ni Lochlainn
communications@tcd.ie
353-189-62310
Trinity College Dublin
Source:Eurekalert

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