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New research on mutation in yeast can enhance understanding of human diseases
Date:6/19/2008

ting base pairs can be much more dramatic than substituting one base pair for another.

Comparing the mutation rates and spectrums of these two model organisms informs researchers' assumptions about mutation relevant to human health. "We were surprised that there isn't a common spectrum of mutation," says Thomas. "However, it's exciting, because if we can describe patterns of mutation, maybe we can understand why some organisms, including people, are susceptible to certain mutations and not others."

The approach used in this study allows yeast to accumulate mutations in the near absence of natural selection. By doing this, cells with mutations that might otherwise be lost because their cell is outgrown by others can continue to survive and be analyzed for their mutations. With this study, Thomas and his colleagues overcome a major limitation to the study of mutation by using a new generation of sequencing technology that let them sequence the entire genome of each yeast strain and to identify the rare mutational events that have taken place. This way, the yeast accumulate mutations that might otherwise make them "bad yeast" the weak survive and look for them across the entire 10 million base pair genome.

"The beer you make with this yeast is horrible," Thomas jokes.


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Contact: Beth Potier
beth.potier@unh.edu
603-862-1566
University of New Hampshire
Source:Eurekalert

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