Navigation Links
New research model of human prostate cancer shows cancer development
Date:7/1/2010

Progress toward understanding the role of sex hormones in the growth of prostate cancerthe most common cancer in U.S. menhas been hindered by the lack of a suitable laboratory research model. Now researchers say they have developed the first model of hormone-induced human prostate cancer initiation and progression.

Their results were presented at The Endocrine Society's 92nd Annual Meeting in San Diego.

"We hope this model will speed up the process of testing preventive therapies for prostate cancer as well as help clarify the hormonal mechanisms in the development of this cancer," said Gail Prins, PhD, a professor and reproductive physiologist at the University of Illinois at Chicago, who is a co-author of the study.

"Sex hormonestestosterone and estrogensare involved in regulating the growth of prostate cancer, but the mechanisms are not well established," Prins said.

Currently the only available laboratory models of human prostate cancer are xenograftscancerous human tissues grafted under the skin of animalsor "transformed" cancer cell lines containing cells that originally came from patients with prostate cancer. However, Prins said, "If you want to study the initial development of cancereither naturally or inducedor its prevention, you cannot use a model of existing cancer, such as transformed cell lines."

To study the progression of prostate cancer from normal cells into cancerous cells requires the use of animal prostate cells. Animal models, however, do not directly mimic all aspects of human prostate cancer, experts say.

Prins and her colleagues created their model using prostate cells obtained from a deceased organ donor who did not have prostate disease. They isolated and grew, in 3-D culture, adult prostate progenitor cellscells with stem cell-like properties that self-renew and may become cancerous. In 3-D culture, the progenitor cells proliferate and form small spheroids, called prostaspheres, which are capable of regenerating tissues.

The researchers combined these human prostaspheres with embryonic cells from the prostate of a rat and then transplanted the mixed cells under the kidney capsule of mice. These transplants regenerated into normal human prostate-like tissues and secreted prostate-specific antigen (PSA), which confirmed human functionality, according to Prins.

The mice then received a drug pellet containing testosterone and estradiol estrogen. A cancerous tumor formed at the transplant site.

"We were able to induce hormonally driven prostate cancer in these recombinant tissues," Prins said. "Using this model, we can follow the entire pathway of the cancerfrom normal tissue to initiation and progression."


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Parkinson's Disease Patient Tells Personal Story to Benefit PD Research; Donates Book Proceeds to PD Charities
2. Parkinsons Transplant Mystery Solved, Researchers Say
3. BIDMC researcher receives Young Investigator Award from Prostate Cancer Foundation
4. Scripps Research scientists share $2 million in Florida state research grants
5. Psychological research conducted in WEIRD nations may not apply to global populations
6. Researchers suggest new paradigm for breast cancer screening
7. Hebrew University added to Singapore research program
8. Sheldon Manufacturing, Inc. Announces New Ergonomic Bactron Anaerobic Chamber For Microbiology Research
9. Of lice and man: Researchers sequence human body louse genome
10. AcademyHealth honors leading health services researchers
11. APS urges greater federal investment in energy research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... , ... June 28, 2017 , ... ... is pleased to announce that a two year study conducted by the University ... Creek zeolite was successful in remediating potash brine-impacted groundwater. As a part of ...
(Date:6/27/2017)... ... June 27, 2017 , ... Excel Medical, the ... to the position of Executive Vice President, Sales and Marketing. Finnegan is a ... and medical device sales leadership. He has received industry recognition for innovations and ...
(Date:6/27/2017)... ... June 27, 2017 , ... The Congressional Budget Office (CBO) projects that ... the 2010 Patient Protection and Affordable Care Act (ACA), would result in 22 million ... under current law. , More than 20 million Americans have gained health insurance under ...
(Date:6/27/2017)... (PRWEB) , ... June 27, 2017 , ... ... management assistance and personal financial planning services to residents of southern New Hampshire, ... charity event that promises to fight hunger and homelessness in the region. , ...
(Date:6/27/2017)... ... June 27, 2017 , ... Hammer Strength, the world’s leading ... named Javair Gillett of the Houston Rockets the NBSCA Strength & Conditioning Coach of ... decided by NBSCA members who vote to select the coach who embodies the highest ...
Breaking Medicine News(10 mins):
(Date:6/27/2017)... , Jun 27, 2017   NuEyes (NuEyes ... of funding to fuel its growth in helping the legally ... (Osterhout Design Group), the leading developer of augmented, virtual ... technology sits. The undisclosed funding amount was provided ... firm, Arab Angel, with offices in Abu Dhabi ...
(Date:6/16/2017)... BOSTON , June 16, 2017  Exactly 50 years ... kicked off what later became known as the San Francisco ... www.northernlight.com ) is unveiling two radical innovations in strategic market ... summer.  This announcement marks the beginning of Northern Light,s "Summer ... ...
(Date:6/12/2017)... Inc., a biotechnology company focused on the development of novel ... and Head of Virology Kristin Bedard has been invited to ... Beyond meeting sponsored by Life Science Washington.  This Symposium ... PDT at the Agora Conference Center in Seattle, ... joined by other leaders in infectious disease research and the ...
Breaking Medicine Technology: