Navigation Links
New research model of human prostate cancer shows cancer development
Date:7/1/2010

Progress toward understanding the role of sex hormones in the growth of prostate cancerthe most common cancer in U.S. menhas been hindered by the lack of a suitable laboratory research model. Now researchers say they have developed the first model of hormone-induced human prostate cancer initiation and progression.

Their results were presented at The Endocrine Society's 92nd Annual Meeting in San Diego.

"We hope this model will speed up the process of testing preventive therapies for prostate cancer as well as help clarify the hormonal mechanisms in the development of this cancer," said Gail Prins, PhD, a professor and reproductive physiologist at the University of Illinois at Chicago, who is a co-author of the study.

"Sex hormonestestosterone and estrogensare involved in regulating the growth of prostate cancer, but the mechanisms are not well established," Prins said.

Currently the only available laboratory models of human prostate cancer are xenograftscancerous human tissues grafted under the skin of animalsor "transformed" cancer cell lines containing cells that originally came from patients with prostate cancer. However, Prins said, "If you want to study the initial development of cancereither naturally or inducedor its prevention, you cannot use a model of existing cancer, such as transformed cell lines."

To study the progression of prostate cancer from normal cells into cancerous cells requires the use of animal prostate cells. Animal models, however, do not directly mimic all aspects of human prostate cancer, experts say.

Prins and her colleagues created their model using prostate cells obtained from a deceased organ donor who did not have prostate disease. They isolated and grew, in 3-D culture, adult prostate progenitor cellscells with stem cell-like properties that self-renew and may become cancerous. In 3-D culture, the progenitor cells proliferate and form small spheroids, called prostasphere
'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Parkinson's Disease Patient Tells Personal Story to Benefit PD Research; Donates Book Proceeds to PD Charities
2. Parkinsons Transplant Mystery Solved, Researchers Say
3. BIDMC researcher receives Young Investigator Award from Prostate Cancer Foundation
4. Scripps Research scientists share $2 million in Florida state research grants
5. Psychological research conducted in WEIRD nations may not apply to global populations
6. Researchers suggest new paradigm for breast cancer screening
7. Hebrew University added to Singapore research program
8. Sheldon Manufacturing, Inc. Announces New Ergonomic Bactron Anaerobic Chamber For Microbiology Research
9. Of lice and man: Researchers sequence human body louse genome
10. AcademyHealth honors leading health services researchers
11. APS urges greater federal investment in energy research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... According to new report "C4ISR Market ... to register a CAGR of 2.28% to reach ... data tables and 76 figures spread through 185 ... http://www.marketsandmarkets.com/Market-Reports/c4isr-market-1315.html , Early buyers will receive 10% ... The report provides market analysis of the global ...
(Date:7/11/2014)... 11, 2014 As transvaginal mesh ... Johnson & Johnson’s Ethicon Inc. unit continue to ... that the Texas Attorney General’s Office has acknowledged ... surgical mesh products used to treat pelvic organ ... report from kens5.com, the probe began nearly two ...
(Date:7/11/2014)... -- Reducing the number of deer in an area ... other tick-borne infections among people, new research indicates. ... to reduce human interactions with deer, infected nymphal ticks ... wrote. White-tailed deer are the primary host for ... The study included nearly all the permanent residents ...
(Date:7/11/2014)... HealthDay Reporter THURSDAY, July 10, ... who was thought to be cured by immediate and aggressive ... of the AIDS-causing virus in her bloodstream, disappointed federal officials ... old, had remained virus-free even though she stopped taking HIV ... her remission would open the door to a functional cure ...
(Date:7/11/2014)... 11, 2014 Microbiology testing is a ... diagnostics industry, which is expected to pose the biggest ... sector owes its growth to the ongoing spread of ... worldwide and a major factor leading to the upsurge ... bio-terrorism, and a broader availability of immunosuppressants, among others. ...
Breaking Medicine News(10 mins):Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 2Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 3Health News:C4ISR Market Estimated to Reach $93.04 Billion by 2019 - New Report by MarketsandMarkets 4Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 2Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 3Health News:Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Report of Texas Probe into Ethicon Pelvic Mesh Marketing 4Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 2Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 3Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 2Health News:World Virology and Bacteriology Testing Sector Discussed in Comprehensive VPG Research Report Published at MarketPublishers.com 3
... , MONDAY, Dec. 19 (HealthDay News) -- A new analysis on ... cuts fracture risk in older adults, but only when taken with ... D -- present in a small number of foods and produced ... Preventive Services Task Force (USPSTF) also indicates that it,s too soon ...
... jeopardize access to medical care for many millions ... the American College of Physicians (ACP) in a ... Senate leadership. ACP is the largest physician ... United States, representing 132,000 internal medicine specialist physicians ...
... have discovered a missing link between the body,s biological ... help avoid the serious side effects of drugs used ... paper published last week in Nature, scientists at the ... that control the body,s biological rhythms, known as cryptochromes, ...
... , MONDAY, Dec. 19 (HealthDay News) -- Blood ... for heart disease and stroke, a new study suggests. ... pressure readings were tracked for an average of 14 years. ... normal levels by age 55 had the lowest lifetime risk ...
... mice suggest that blocking the production of small molecules ... may represent a novel strategy for treating cancer by ... research is the first to show that EETs work ... protein known to induce blood vessel growth. Together, EETs ...
... naturally in the body from a major component of ... are currently in clinical trials for the treatment of ... led by Dipak Panigrahy and Mark Kieran, at ... Institute for Systems Biology, Seattle; and Darryl Zeldin, at ...
Cached Medicine News:Health News:Vitamin D Helps Bone Health Only With Calcium: Report 2Health News:Vitamin D Helps Bone Health Only With Calcium: Report 3Health News:Congress' 'disarray' makes it 'likely' that 27 percent Medicare cut will go in effect 2Health News:Salk discovery may lead to safer treatments for asthma, allergies and arthritis 2Health News:Salk discovery may lead to safer treatments for asthma, allergies and arthritis 3Health News:Blood Pressure Control in Middle Age Can Lower Lifetime Heart Risk 2Health News:NIH scientists find a potential new avenue for cancer therapies 2Health News:NIH scientists find a potential new avenue for cancer therapies 3
(Date:7/11/2014)... July 11, 2014 According to ... "Endoscopy Devices Market (Endoscopes, Endoscopic Operative Devices, and Visualization ... and Forecast, 2013-2019" the global endoscopy devices market was ... expected to grow at a CAGR of 6.8% from ... USD 36.9 billion in 2019. Browse the ...
(Date:7/10/2014)... India , July 11, 2014  Major ... treatment of cancer are being highlighted in a ... Mumbai from 10-12 July, 2014.  Renowned national ... to share best practices and exchange knowledge on ... precise, accurate and efficient. The ...
(Date:7/10/2014)... , July 10, 2014  RESMED INC. (NYSE: ... quarter and fiscal year ended June 30, 2014 results on ... market close. A press release with ResMed,s results will be ... will host a webcast to discuss operating results and future ... at 1:30 p.m. US Pacific Time and the live webcast ...
Breaking Medicine Technology:Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2
... Published in the September 18th New England Journal of,Medicine, ... colorectal cancer. Many,of these deaths could be prevented by ... older who should be screened for the disease are,not ... and safety,concerns associated with current screening exams., However, ...
... 17 The Department of,Justice announced today that ... CEO,Roundtable on Cancer (CRC) to develop and publicize ... cancer treatments. The Department said,the language is not ... to help,increase efficiency in contract negotiations, potentially reducing ...
Cached Medicine Technology:MultiVu Video Feed: Major Trial Demonstrates Comparable Accuracy of Virtual Colonoscopy and Standard Colonoscopy 2Justice Department Will Not Oppose CEO Roundtable on Cancer's Proposal 2
... Advia 1650 has minimal requirements ... as 2 L/test), reagent consumption ... and water consumption (25 L/hour) ... Optional universal rack handler facilitates ...
Iron (Total/Ferene). Storage temp: 15 - 30 C. Linearity: 0 - 500 ug/dl. Expected values: from males 60 - 160 ug/dl, from females 43 - 140 ug/dl. Available with Calibrator and Number of test are 120....
Iron Total (TIBC) (Iron Buffer + Iron Color=Std.). An Automated analyzer test kits....
For the quantitative determination of iron, total iron-binding capacity in human serum....
Medicine Products: