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New research may show why some prostate cancer recurs after treatment
Date:10/11/2007

lls are actually capable of such a conversion.

New medications are being tested in the early stages of clinical trials with the goals of blocking androgen synthesis. Abiraterone, for example, seeks to inhibit the enzymes in the metabolic pathways that convert cholesterol to androgens, and work by blocking androgen synthesis in both the adrenal gland and possibly in the tumors themselves. Other classes of drugs being tested attempt to more completely block interactions with the receptor for androgens within the tumor cells, or alter the degradation of androgens. Rather than continuous treatment which is associated with side-effects, a strategy of maximally inhibiting the androgen axis for a short-time or on an intermittent basis could have the effect of destroying or suppressing cancer cell growth for long time periods. Investigators leading these trials also discussed initial findings in the session at PCFs annual Scientific Retreat.

Nelson lauded the Prostate Cancer Foundation for their leadership role in funding research in the field. What PCF has allowed is exploration of innovative and high risk ideas, instrumental in allowing us to pursue this area of investigation, emphasized Nelson.


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Contact: Sharon Reis
prostate@gymr.com
202-745-5100
GYMR
Source:Eurekalert

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