Navigation Links
New research may lead to improved diagnosis of autism
Date:5/30/2011

OAK BROOK, Ill. Functional magnetic resonance imaging (fMRI) may provide an early and objective indicator of autism, according to researchers at Columbia University in New York City, who used the technique to document language impairment in autistic children. Results of their study appear online and in the August issue of Radiology.

Autism is a spectrum disorder characterized by repetitive behaviors and impaired language, communication and social interactions. According to the Centers for Disease Control and Prevention, it is estimated that as many as one in every 110 children is affected by autism.

"With the extraordinarily high prevalence of autism, you would think there would be an objective diagnosis for the disorder," said Joy Hirsch, Ph.D., a professor at Columbia University Medical Center and director of the Functional MRI Laboratory. "However, the diagnosis of autism currently remains limited to parent and clinician observation of missed developmental milestones."

In the study, researchers performed fMRI exams on 15 control children (mean age: 12.1) and 12 language-impaired and age-matched autistic children (mean age: 12.4). Using fMRI, the researchers were able to measure neural activity in working brain tissues, while the children listened to recordings of their parents talking to them.

Activation levels during passive stimulation were measured within two regions of the brain: the primary auditory cortex (A1) and superior temporal gyrus (STG), a region associated with sentence comprehension. Brain activation maps for each patient were then computed using statistical linear modeling.

Activity in the A1 region of the brain did not differ between autistic and control patients. However, activation within the STG was greater for control children relative to autistic patients.

"These findings first tell us that the autistic children in our study appeared normal with respect to the primary auditory system," Dr. Hirsch said. "But it appears that the STG in the autistic brains was not as sensitive to the language narratives as was the STG in the brains of the typical children."

An additional 27 autistic children undergoing routine MRI exams with sedation were also included in the study. Using a similar analysis of sedation-adjusted values from the control group, the researchers identified 26 of 27 (96 percent) sedated autistic patients with autism.

"This study suggests that fMRI acquired during listening to a language narrative can be used to distinguish children with autism from those without," Dr. Hirsch said. "Based on these initial findings, future studies using these or similar fMRI methods may result in an early and objective imaging indicator for autism."

Some children with autism spectrum disorders can benefit from intensive behavior therapy, but early intervention is key.

"The need for an early, objective diagnosis is enormous," Dr. Hirsch said.


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 27, 2016 , ... TherapySites, the leading website ... Tennessee Counseling Association. This new relationship allows TherapySites to continue to ... adding exclusive benefits and promotional offers. , "TCA is extremely excited about this ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution ... the emergency ambulance transport experience for the millions of people who require these ... disrupted the taxi industry through the use of technology. Now, SmartEMS has put ...
(Date:6/26/2016)... PLAINSBORO, N.J. (PRWEB) , ... June 27, 2016 , ... ... same sources, yet in many ways they remain in the eye of the beholder, ... Oncology (EBO), a publication of The American Journal of Managed Care. For the full ...
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a ... can give their videos a whole new perspective by using the title layers ... Film Studios. , ProSlice Levels contains over 30 Different presets to choose from. ...
(Date:6/26/2016)... NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and ... to be personalized through a fitness app. The fitness app plans to fix the two ... currently only offer a one size fits all type program , They don’t ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Mass. , June 24, 2016   ... Spaulding Rehabilitation Network,s Dean Center for Tick ... Physical Medicine and Rehabilitation, MIT Hacking Medicine, University ... for Innovation, today announced the five finalists of ... for Lyme disease.  More than 100 scientists, clinicians, ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June ... -based mobile pulmonary function testing company, is now able to ... devices developed by ndd Medical Technologies , Inc. ... done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ... , can get any needed testing done in the comfort of ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
Breaking Medicine Technology: