Navigation Links
New research may lead to improved diagnosis of autism
Date:5/30/2011

OAK BROOK, Ill. Functional magnetic resonance imaging (fMRI) may provide an early and objective indicator of autism, according to researchers at Columbia University in New York City, who used the technique to document language impairment in autistic children. Results of their study appear online and in the August issue of Radiology.

Autism is a spectrum disorder characterized by repetitive behaviors and impaired language, communication and social interactions. According to the Centers for Disease Control and Prevention, it is estimated that as many as one in every 110 children is affected by autism.

"With the extraordinarily high prevalence of autism, you would think there would be an objective diagnosis for the disorder," said Joy Hirsch, Ph.D., a professor at Columbia University Medical Center and director of the Functional MRI Laboratory. "However, the diagnosis of autism currently remains limited to parent and clinician observation of missed developmental milestones."

In the study, researchers performed fMRI exams on 15 control children (mean age: 12.1) and 12 language-impaired and age-matched autistic children (mean age: 12.4). Using fMRI, the researchers were able to measure neural activity in working brain tissues, while the children listened to recordings of their parents talking to them.

Activation levels during passive stimulation were measured within two regions of the brain: the primary auditory cortex (A1) and superior temporal gyrus (STG), a region associated with sentence comprehension. Brain activation maps for each patient were then computed using statistical linear modeling.

Activity in the A1 region of the brain did not differ between autistic and control patients. However, activation within the STG was greater for control children relative to autistic patients.

"These findings first tell us that the autistic children in our study appeared normal with respect to the primary auditory system," Dr. Hirsch said. "But it appears that the STG in the autistic brains was not as sensitive to the language narratives as was the STG in the brains of the typical children."

An additional 27 autistic children undergoing routine MRI exams with sedation were also included in the study. Using a similar analysis of sedation-adjusted values from the control group, the researchers identified 26 of 27 (96 percent) sedated autistic patients with autism.

"This study suggests that fMRI acquired during listening to a language narrative can be used to distinguish children with autism from those without," Dr. Hirsch said. "Based on these initial findings, future studies using these or similar fMRI methods may result in an early and objective imaging indicator for autism."

Some children with autism spectrum disorders can benefit from intensive behavior therapy, but early intervention is key.

"The need for an early, objective diagnosis is enormous," Dr. Hirsch said.


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... ... demand for minimally invasive, endoscopic spine surgeries in the Montgomery County, Howard County ... patients in the Germantown office of American Spine every Monday. He will also ...
(Date:5/24/2016)... Slidell, LA (PRWEB) , ... May 24, 2016 , ... ... which will feature a unique and patented refillable hanging wipe dispenser. The campaign kick-off ... 1, 2016 and will end June 25, 2016. The goal is to raise $1,000 ...
(Date:5/24/2016)... ... 24, 2016 , ... PhishLine, the best-in-class, enterprise level security ... Vice President of Sales. Cifolelli’s primary responsibilities include management of the company’s ... expanding field of organizational social engineering. , “We are delighted to have ...
(Date:5/24/2016)... ... May 24, 2016 , ... Fire Door Solutions, ... one resource, from start to finish, for Life Safety compliance. These expanded ... surveys requested by the Joint Commission, and fire stopping reviews, inspections, and repairs. ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... corporate identity and website at its “Transforming Outcomes” User Conference in Las Vegas ... reflect i2i’s ongoing success to set the market standard for meaningful population health ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... May 24, 2016 ARANZ Medical ... the healthcare sector, has been named the Coretex Hi-Tech Emerging ... 2016. Dr Bruce Davey , CEO of ... team.  It,s really good to be recognised for the work ... products are used in 35 countries around the world from ...
(Date:5/24/2016)... May 24, 2016 Los ... terapia del mundo, introduce catéteres para la intervención ... OrbusNeich, una compañía global especializada en el suministro ... expandido su cartera incluyendo productos para tratar la ... Scoreflex™ PTA son los dispositivos de primera entrada ...
(Date:5/23/2016)... , May 23, 2016 ... "Patient Handling Equipment Market by Product (Wheelchair, Scooters, ... Care (Bariatric Care, Critical Care, Wound), Accessories (Lifting, ... Forecast to 2021", published by MarketsandMarkets, the patient ... 17.18 Billion by 2021 at a CAGR of ...
Breaking Medicine Technology: