Navigation Links
New research may lead to earlier diagnosis and treatment of primary biliary cirrhosis in families
Date:9/10/2007

ROCHESTER, Minn. -- Mayo Clinic researchers have found that first-degree relatives (i.e., parents, siblings, children) of patients with primary biliary cirrhosis (PBC) are more likely to have the biomarker of the disease in their blood. Armed with this new information, physicians could screen and assess first-degree relatives of PBC patients with a simple blood test, enabling them to diagnose and treat more patients before the disease causes irreversible liver damage. These findings were published in this months issue of Hepatology.

PBC is a chronic liver disease that affects nearly 50,000 people (primarily women) in North America. In individuals who have PBC, the bile ducts are slowly destroyed, causing harmful substances to build up in the liver and sometimes resulting in irreversible scarring of liver tissue and liver failure. About half of PBC patients have no symptoms and are diagnosed following abnormal results of routine liver tests.

Anti-mitochondrial antibodies are the biomarker, or the substance that correlates with the risk or presence of a disease, for PBC. This study, the largest of its kind, tested for anti-mitochondrial antibodies in 306 first-degree relatives of adult PBC patients and 196 healthy adults. The prevalence in first-degree relatives was 13.1 percent, compared to 1 percent in the control group of healthy adults. Even greater prevalence was found in female relatives, with 20.7 percent of sisters, 15.1 percent of mothers and 9.8 percent of daughters having anti-mitochondrial antibodies in their blood. While testing positive for anti-mitochondrial antibodies does not always lead to a diagnosis of PBC, the presence of these antibodies indicates a predisposition to develop the illness, particularly in the context of family history of the disease.

Most PBC patients have no symptoms, but early detection is important because timely treatment can slow the progression of the disease before liver failure occurs, says Konstantinos Lazaridis, M.D., the studys lead author and a hepatologist at Mayo Clinic. Because collectively one in five sisters of a PBC patient has anti-mitochondrial antibodies in their blood, we think it is worthwhile to screen first-degree relatives, particularly those older than 40 years, for this biomarker. It is a simple, inexpensive blood test that could lead to earlier diagnosis and treatment -- and ultimately, better outcomes for PBC patients.

According to Dr. Lazaridis, the studys findings regarding anti-mitochondrial antibodies in PBC relatives could also be important to better understanding the known genetic predisposition to PBC. His research team plans to continue screening and monitoring first-degree relatives of PBC patients over many years to further examine these findings and to shed light on the cause of this disease.


'/>"/>

Contact: Elizabeth Rice
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Stem cell research- now Nobel Laureates join the debate
3. Researchers urge caution in using ear tube surgery
4. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
5. Spouses and other partners lower blood pressure says new research
6. Researchers Scale to assess the Severity of Epilepsy in Kids
7. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
8. Research of Ritalin
9. New Hair in 15 Days Could Now Be A Possibility Say Researchers
10. Researchers at Cornell University as been reported using research fund by false claims
11. Better Research Rats To Help In Learning About Hypertension
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... ... March 22, 2017 , ... Drs. Jennifer Houck, Lauren ... base to accept new patients in need of skilled pediatric dentistry in ... Dental Care offers pediatric patients routine treatments, including cavities, sealants and fluoride applications, in ...
(Date:3/22/2017)... ... March 22, 2017 , ... Intrinsic Imaging, ... therapeutic experience and operational excellence in oncology clinical trials, proudly announces today that ... treatment of non-small cell lung cancer and small cell lung cancer. , Throughout ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... consultation, financial planning, and related services to communities across eastern Texas, is announcing ... goal of providing meals to hungry children and adults. , Consistently a ...
(Date:3/22/2017)... ... March 22, 2017 , ... Chris Humphrey Insurance Agency, a North Carolina firm ... the coastal plains region, is initiating a charity event to raise support for five ... diagnosed with leukemia on a Friday evening in September 2014. At the time, Dillyn ...
(Date:3/22/2017)... ... March 22, 2017 , ... HumanHaus is proud to announce ... The conventional broom was great when it was invented, but our customers today are ... parents, the social young couple, the empty nesters and retired that want to travel. ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... LEXINGTON, Kentucky , March 22, 2017 ... Development and Manufacturing Organization (CDMO), held a special event ... its facilities in Lexington, Kentucky . ... Bevin , Piramal Group Chairman Ajay Piramal, and ... ...
(Date:3/22/2017)... 22, 2017 FinancialBuzz.com News Commentary  ... According to a report by ... estimated $6.6 billion in 2016, and is projected to grow at ... than $24 billion by 2025. The medical cannabis market is projected ... billion in 2016, to an estimated $13.3 billion in 2025. These ...
(Date:3/22/2017)... -- EMD Serono, the biopharmaceutical business of Merck KGaA, Darmstadt, ... Canada , today announced two new real-world data ... the 65 th Annual Pacific Coast Reproductive Society (PCRS) ... March 24 th .   The results being presented ... July 2009 to December 2015 containing data from 15 fertility ...
Breaking Medicine Technology: