Navigation Links
New research indicates that a common heart drug
Date:2/27/2008

Boston, MA Researchers from Boston University School of Medicine and Harvard Medical School have found that diltiazem, a drug used in the treatment of high blood pressure, reduces cocaine cravings in a rat model. These findings will appear in the March issue of the leading medical journal Nature Neuroscience.

Previous work showed that two brain chemicals, dopamine and glutamate, independently contribute to the development of cocaine addiction. This new research indicates that calcium channels provide critical links between dopamine and glutamate that drives the intense craving associated with cocaine addiction. Diltiazem, one of a class of drugs known as calcium channel blockers, disrupts the connection between dopamine and glutamate formed during chronic cocaine use.

According to the researchers, brain calcium plays an important role in learning and memory in that calcium influences an enzyme known as the memory molecule. Our work shows that cocaine increases the levels of this molecule specifically in a brain area that controls motivation. Thus, cocaine use teaches the brain to be addicted, resulting in a dysfunctional form of learning that drives the overwhelming desire to consume more cocaine, said senior author Chris Pierce, a professor of pharmacology and psychiatry at Boston University School of Medicine.

Currently, there are no effective drug therapies for cocaine addiction. Pierce noted that research such as this using animal models could lead to desperately needed medications. The strength of this work is that it tells us something fundamental about how brain chemistry changes as cocaine addiction takes hold. Importantly, our findings also suggest new strategies for developing cocaine addiction therapies, which thus far remain elusive, he added.


'/>"/>
Contact: Gina Digravio
gina.digravio@bmc.org
617-638-8491
Boston University
Source:Eurekalert

0

GOOD

Page: 1

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... new study suggests that disturbed sleep in adolescents ... greater uncertainly about future success. However, perceived ... to have a protective effect. , Results ... depressed mood and greater uncertainty about future success. ... from teachers were associated with significantly fewer sleep ...
(Date:5/22/2013)... Auburn, AL (PRWEB) May 22, 2013 ... Jr. of Birmingham, Alabama. A University of Alabama graduate, ... its surrounding areas. As a TeethWhiteningforFree.com dentist, he extends ... office for a routine exam and/or check up. Only ... health makes them eligible for whitening treatments. ...
(Date:5/22/2013)... With the health of a growing fetus largely dependent ... that many women become hyperaware of everything that goes into ... on a pregnancy test. At no other time in life ... (like caffeine, alcohol, and nicotine) stronger than during pregnancy. But ... Does this increased awareness during pregnancy extend to the lotions, ...
(Date:5/22/2013)... Peak Solar introduces unique, interactive solar training seminars, which ... make informed buying choices. Research studies tell companies that ... to give them the tools needed to make informed ... Solar training seminars will be introduced onto the website, ... kits . , Poised to help both residential and ...
(Date:5/22/2013)... CA (PRWEB) May 22, 2013 Many problems ... great deal of pain for a patient if left untreated. ... their pain could be easily fixed through occlusal adjustment. ... or neck and back pain should have their dentist check ... change the bite and can lead to problems if the ...
Breaking Medicine News(10 mins):Health News:Parent and teacher support protects teens from sleep problems and depression 2Health News:Dr. James Sanderson, Jr. Of SanDentistry in Hoover, Alabama Joins the TeethWhiteningforFree.com Family 2Health News:Fairhaven Health Launches New PregnancyPlus Natural Deodorant Designed Specifically for Pregnant Women 2Health News:Online Solar Training Seminars Aimed at Informing Consumers 2Health News:Dr. Martin N. Gorman: Make Headaches, Sensitive Teeth and Neck or Back Pain a Thing of the Past 2
... people with no history of mental illness feel suicidal. Prozac ... has been one of the pharmaceutical industries biggest success stories ... of drugs known as SSRIs (selective serotonin reuptake inhibitors). This ... were hailed as "wonder drugs" when they first hit the ...
... both in the USA and all over the world. The drug ... long-term. It raises the risk of high blood pressure, diabetes, cancer ... long term, and there has seen to be a need, now, ... Harvard University in the USA have discovered that the drug bupropion, ...
... Inhaling too much cocaine is well known to cause damage ... it can force the body to attack itself.New Scientist reports ... hospitals with cocaine related emergencies has jumped from around 80,000 ... ,Working on rabbit hearts, a University of Michigan team have ...
... a twin study reveals that cholesterol levels are controlled ... blood cholesterol are often advised to go on a ... known that reducing fat intake can reduce cholesterol levels. ... hypercholesterolaemia (FH) which leads to high cholesterol.// People with ...
... are trialling the first long-acting male contraceptive which stops the ... is a combination of hormones. ,In the trial, men ... of the male hormone testosterone is placed under the skin ... Kings Hospital in UK says the technique works by putting ...
... Healthcare announced a strategic alliance with Mumbai-based Kopran ... collaborative research while taking over the Kopran's anti-hypertensive ... is the largest brand in the cardiovascular segment. ... Pharma brands. // , As a ...
Cached Medicine News:Health News:Wonder drug - could end in disaster 2
(Date:5/22/2013)... , 22. Mai 2013  Grifols, ein ... Barcelona , Spanien, präsentierte ... eine höhere Dosis von PROLASTIN©-C (Alpha1-Proteinasehemmer [human]) ... Alpha1-Antitrypsinmangel (AAT) auf ein Niveau anhebt, das ... Bereichs liegt. ATT-Mangel ist eine lebensbedrohliche, genetische ...
(Date:5/22/2013)... Israel , May 22, 2013  Rosetta ... developer and provider of microRNA-based molecular diagnostics, announces that ... Chief Executive Officer of Rosetta Genomics, will deliver a ... place from June 3-6, 2013 in New York City.  ... 4 th at 2:00 p.m. Eastern time. ...
(Date:5/22/2013)... , May 22, 2013  Medifocus, Inc. (OTCQX: MDFZF and ... , Chief Operating Officer, will present at the Second Annual ... New York City at the Grand ... to begin at 4:00 p.m. EDT and will be available ...   http://wsw.com/webcast/marcum/mfs.v/   For more information and registration, ...
Breaking Medicine Technology:Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 2Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 3Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 4Rosetta Genomics to Present at the Jefferies 2013 Healthcare Conference 2Rosetta Genomics to Present at the Jefferies 2013 Healthcare Conference 3Medifocus, Inc. to Present At The Second Annual Marcum LLP MicroCap Conference 2Medifocus, Inc. to Present At The Second Annual Marcum LLP MicroCap Conference 3
... CLEVELAND, Dec. 1, 2011  NDI, a leading venture capital ... office, a third major location in addition to its ... The Minneapolis office will be run by medical device ... for Market Development. (Photo: ...
... Company (NYSE: LLY ) has been named one of ... partnership with FORTUNE and the RBL Group. Lilly ranked 16th on ... The survey is one of the most comprehensive studies ... Companies first complete an extensive survey, and senior executives from ...
Cached Medicine Technology:NDI Brings on Industry Veteran Mark Stultz to Head Up New Minneapolis Office 2Eli Lilly and Company Named a Top Global Company for Leaders 2
Shake 'n' Stack Oven - New Model (includes 10 bottle capacity rotisserie, adjustable feet, drip tray, manual PLUS Shaker Platform)...
Inquire...
... Hybridization Oven / Shaker : Temperature ... platform for the hybridization and incubation of ... be used for gel processing and staining. ... volumes to be used providing enhanced sensitivity ...
... Bio-Dot and Bio-Dot SF (slot format) microfiltration ... protein or nucleic acid in solution onto ... can be accommodated by using interchangeable templates ... 48-well slot format Bio-Dot SF apparatus. Each ...
Medicine Products: