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New research identifies more effective tools for detection of colorectal cancer
Date:6/1/2009

risks, perforation has been considered by some to be the most serious, so we wanted to determine the actual rate of perforation to help patients and their physicians make informed decisions. The good news is that we found the risk of perforation during colonoscopy is extremely low."

Fehmi and his colleagues searched databases from 1950 through 2007 for all English language abstracts of prospective studies related to perforation rates. They also reviewed abstracts presented at all major national and international gastroenterology meetings from 2005 to 2007. Seventeen studies, consisting of 274,265 colonoscopies, met the inclusion criteria.

Pooled perforation rate in therapeutic colonoscopies was found to be 0.066 percent or approximately 1 in 1500 and in diagnostic colonoscopies was found to be .017 percent or approximately 1 in 6000. Therapeutic colonoscopy, which is required to remove lesions if polyps are present, was associated with a higher risk of perforation. The analysis also identified a trend towards decreasing perforation rates for both therapeutic procedures and diagnostic procedures.

Fehmi said that while colonoscopy is a safe procedure, there are some risks that need to be explored further. Studies should be done in the community and university setting and patients should be stratified by different risk factors and indications. Future prospective studies should also employ a systematic follow up (at day seven or 30) to ensure capture of all complications. These quoted rates of perforation can serve as a quality, performance, or outcome benchmark.

Dr. Choksi will present these data on Sunday, May 31, 2009 at 2:15 p.m. CDT in S406A, McCormick Place.


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Contact: Aimee Frank
newsroom@gastro.org
301-941-2620
American Gastroenterological Association
Source:Eurekalert

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