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New research identifies more effective tools for detection of colorectal cancer
Date:6/1/2009

irst and second colonoscopy were at higher risk for developing subsequent pre-malignant adenomas after the second colonoscopy. Most importantly, more than 8 percent of this group had more concerning, advanced adenomas removed at the third colonoscopy (including one cancer) vs. 0 percent for all other patients. Although patients with a negative first or second colonoscopy might be appropriate for a third examination after a 10 year interval (similar to the general population), the group with adenomas found at first and second colonoscopy should undergo third colonoscopy as dictated by current guidelines, Mellen said.

Dr. Mellen will present these data on Monday, June 1 at 2:15 p.m. CDT in S104, McCormick Place.

Optical Biopsy at Colonoscopy: Are We Ready? DISCARD Study: Early Results (Abstract #721)

Researchers have studied a method that may be more effective at examining and identifying polyps that are precancerous, thereby eliminating the time and expense of sending biopsies to pathology.

Under the current colonoscopy protocol, the majority (90 percent) of polyps removed during the procedure are small, less than 10mm, in size and are sent for evaluation of pathology after removal. The removal of polyps reduces the risk of cancer and the number of polyps removed is the basis for determining the frequency of subsequent colonoscopies. Typically, only half of the polyps removed during colonoscopy are discovered to be precancerous.

In a study at St. Mark's Hospital in London, investigators followed four endoscopists with varying levels of experience with optical diagnosis during colonoscopies. The participating colonoscopists used one or a combination of optical modalities to predict the histopathology of each polyp encountered. Each polyp was then removed and sent for formal histopathology. Researchers found that out of the 85 adenomas removed, 92 percent were correctly diagnosed and of the 38 hyperplastic polyps, 95
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Contact: Aimee Frank
newsroom@gastro.org
301-941-2620
American Gastroenterological Association
Source:Eurekalert

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