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New research identifies more effective tools for detection of colorectal cancer
Date:6/1/2009

ught to examine a group of patients that are at higher risk for developing cancer and therefore require more frequent colonoscopy. The visualization and removal of large, villous, or high grade dysplastic polyps signifies the need for repeat colonoscopy in 3 years. All three of these features are typically considered equivalent, and it has been difficult to determine whether one of these polyp characteristics is more predictive of subsequent cancer.

"We wanted to evaluate whether or not one of these polyp features is more predictive of subsequent cancer, and whether 3 years is always appropriate," said Jonathan Mellen, MD, gastroenterology fellow, Phoenix VA Health Care System. "In addition, we wanted to find out more about how a sooner second colonoscopy or a subsequent third colonoscopy might maximize the level of cancer prevention."

Investigators reviewed data from more than 25,000 colonoscopies and only included patients with advanced polyps removed and who underwent both a second and third colonoscopy. Patients were divided into three groups according to which advanced polyp feature was reported. They found that all three groups had a substantial rate of advanced polyp detection at second colonoscopy. The study found that removal of polyps with villous and high grade features was particularly predictive of more future advanced polyps and therefore increased susceptibility to cancer.

In addition, they found that the rate of discovering advanced polyps at third colonoscopy was less than second colonoscopy, although still high enough to suggest that continued exams in this group is an efficient use of resources.

Dr. Mellen will present these data on Monday, June 1 at 3:15 p.m. CDT in S104, McCormick Place.

Can We Really Expect a Therapeutic Benefit After Two Preventive Colonoscopies? A Retrospective VA Medical Center Study (Abstract #432)

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Contact: Aimee Frank
newsroom@gastro.org
301-941-2620
American Gastroenterological Association
Source:Eurekalert

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