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New research identifies more effective tools for detection of colorectal cancer
Date:6/1/2009

detailing endoscopy reports from 61 practice sites across the U.S. from patients who underwent average risk screening colonoscopy done with MCS or DS. They found that even with no difference in prep quality between the two sedation levels, significantly more large polyps were found with DS than with MCS, even after controlling for such factors as age, gender and race; the rate of polyps detected was 25 percent more in patients sedated using deep sedation.

"We don't know for sure whether these polyps would have been found if the patients were examined under moderate sedation," said Katherine M. Hoda, MD, senior fellow, department of gastroenterology, Oregon Health & Science University. "Our study suggests that DS finds more polyps, which could have an impact on the way physicians conduct colonoscopies."

Dr. Hoda cautioned that further studies of many more patients are needed to compare the effects of DS and MCS. This study was small and not randomized, and because it entailed studying information in a database, it may be less definitive than looking at a larger, randomized trial.

Dr. Hoda will present these data on Tuesday, June 2 at 10:30 a.m. CDT in S104, McCormick Place.

Large Tubular Adenomas, Villous Polyps, and Lesions with High Grade Dysplasia: Can We Really Be Comfortable Waiting 3 Years Before Repeat Colonoscopy? A Retrospective VA Medical Center Study (Abstract #435)

After patients undergo colonoscopy with removal of advanced pre-malignant polyps, including those greater than 10mm in size and those with villous or high grade dysplastic features, current guidelines recommend that follow-up colonoscopy be performed after a 3 year interval. However, a recent study suggests that maybe this recommendation should be revisited, as patients who underwent colonoscopy sooner were found to have a high detection rate of advanced polyps, which are more likely to transform into colon cancer.

Investigators so
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Contact: Aimee Frank
newsroom@gastro.org
301-941-2620
American Gastroenterological Association
Source:Eurekalert

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