Navigation Links
New research from the University of Bristol aims to eliminate Streptococcus infections

Professor Howard Jenkinson in the Department of Oral & Dental Science (Dental School) at the University of Bristol has been awarded a grant of 285,000 from The Wellcome Trust to research ways to combat diseases caused by Streptococcus bacteria.

Familiar to those who suffer from strep throat, Streptococcus are the most common bacteria in the human mouth and throat. They are linked to a number of health problems, some mild, some life-threatening, ranging from tooth and gum disease to meningitis, pneumonia, endocarditis (inflammation of the inner layer of the heart) and necrotizing fasciitis (flesh-eating disease). Streptococcus are potent bacteria which are becoming increasingly resistant to treatment by antibiotics. The rate of severe invasive Streptococcus infections is about 60 per 100,000.

The bacteria cause disease in the body by first attaching to tissues. By looking at how this happens, Professor Jenkinson and his team will be able to develop new ways to block the bacteria. One goal is to reduce the rates at which disease-causing Streptococcus are transferred between humans. This could be achieved by developing user-friendly vaccines or natural biological products, which can be taken by mouth, to eliminate the harmful bacteria. This approach lessens antibiotic usage and would significantly decrease infection rates in those most susceptible e.g. children, expectant mothers and the elderly.

Professor Jenkinson says, Streptococcus bacteria are amongst the most commonly encountered in infections, and for the most part we depend totally on antibiotics to fight them. Our research will help develop new infection-control methods that do not rely on conventional antibiotics, and will also help identify people who are at higher risk of infections.

The research will look at the interactions between a protein called AgI/II, which is found on the surface of Streptococcus bacteria, and a protein called gp340, which is found on teeth, in saliva and in airways. The team will measure how sticky the Streptococcus bacteria proteins are as they attach to gp340 on tissue surfaces. By pinpointing the sticky parts of the protein, the team will be able to identify which are responsible for streptococci invading and attacking the body. The research will look at how to block this process and thus develop new ways to prevent bacterial infection.


Contact: Dara O'Hare
University of Bristol

Related medicine news :

1. UF researchers warn parents about dangers of childhood foot burns
2. UCLA researchers find blood stem cells originate and are nurtured in the placenta
3. NIH-funded Vanderbilt Research Seeks Ways to Avoid Information Overload in Health Care Choices Among Seniors
4. White Hat Brands, Juvenile Diabetes Research Foundation Offer the Juice on New Partnership
5. Iowa State University researcher identifies eye disease in canines
6. UCSF researchers validate new model for breast cancer risk assessment in multiple ethnic groups
7. LA BioMed researcher says unexpected increase in cancer risk found
8. Dana Foundation releases arts and cognition research
9. New Home Safety Council(R) Research Shows the Majority of Families Underestimate the Danger of Poisoning Exposure at Home
10. Einstein researchers discover gene mutations linked to longer lifespans
11. VIDEO from Medialink and The Childrens Hospital of Philadelphia: New Research - Rules of the Road for Teens and Passengers
Post Your Comments:
(Date:11/24/2015)... ... 2015 , ... Preparing for the LDT Regulation:, CLIA Won’t Satisfy the FDA, ... , FDA has long asserted that design and manufacture of Laboratory Developed Tests (LDTs) ... not meet the device regulations. , Come up short in an inspection and the ...
(Date:11/24/2015)... Richey, FL (PRWEB) , ... November 24, 2015 , ... ... deems a growing epidemic as deaths from prescription opioids in the United States grew ... and cocaine. In 2013 alone, opioids were involved in 37 percent of all fatal ...
(Date:11/24/2015)... ... November 24, 2015 , ... American Family Care (AFC), the ... of a holiday pop-up clinic located in Metro Atlanta’s North Point Mall. The clinic ... and different way. The location is scheduled to operate through Dec. 24. , Holiday ...
(Date:11/24/2015)... CA (PRWEB) , ... November 24, 2015 , ... Cold Shoulder , LLC launched ... Kickstarter last week and hit their goal of $20,000 in under 10 hours. ... aims to bring the new PRO Weight Loss Vest to the market. , The PRO ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... its exceptional customer service: the TrustDale certification. The award recognizes good companies for ... stone honing , tile and grout, and hard surface restoration company earned this ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... , November 24, 2015 F1000Workspace ... scientists - since it was launched just six months ago. ... management and authoring platform for scientists - since it was ... references have been loaded on to F1000Workspace - ... - since it was launched just six months ago. ...
(Date:11/24/2015)... , Nov. 24, 2015 iRhythm Technologies, Inc. , ... care, today announced that it will participate in the 27th Annual ... New York, NY . Kevin King ... Tuesday December 1, 2015 at 8:50am ET. ... . --> . --> ...
(Date:11/24/2015)... The uptake of recently approved and pipeline premium products for Type 1 ... 2021, says GBI Research . --> ... Diabetes Mellitus (T1DM), will be a key driver of market growth to ... The uptake of recently approved and pipeline premium products for Type ... to 2021, says GBI Research . ...
Breaking Medicine Technology: