Navigation Links
New research finds major activation themes in denture-stomatitis
Date:7/15/2010

Barcelona, Spain Today during the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain, S. Offenbacher will present an abstract titled "Mucosal Gene Expression and Salivary Proteomic Analysis of Candidiasis-Associated Denture-Stomatitis."

The goal of the study was to compare whole-transcriptome, mucosal gene expression in Candida albicans (a parasitic fungus that can infect the mouth) associated chronic denture stomatitis to that of healthy oral mucosa and perform proteomic analyses of potential salivary biomarkers. Denture stomatitis is a condition in which the mucosa underneath a denture becomes inflamed and sometimes painful.

In this study, oral palatal biopsies were obtained from 17 healthy and 15 C. albicans-infected stomatitis subjects for whole-transcriptome analyses using Affymetrix arrays. The presence of C. albicans was confirmed by cytology and cultivable methods and the clinical severity of the stomatitis and denture fit evaluated by the Newton and Kapur Classifications.

A false discovery rate (FDR) of <0.05 was chosen and expression pathways associated with stomatitis were identified using Ingenuity Pathway Analysis.

Saliva was analyzed by two-dimensional liquid chromatography and tandem mass spectrometry for proteomic identification of salivary proteins associated with oral Candidiasis.

Microarray analysis of mRNA expression revealed 3034 genes-in-play differentially expressed in C. albicans stomatitis. 235 genes were upregulated >2-fold including key cytokines [IL1F6, IL1B], chemokines [CXCL1, CCL10, IL8] as well as markers of epithelial suppression and neutrophil recruitment/ activation. Seventy-one genes were down-regulated >2-fold including epithelial adhesion molecules and keratins. Five of the 6 most significant gene ontology pathways involve inflammation and activation of the immune response with CD28 and CTLA signaling
'/>"/>

Contact: Ingrid L. Thomas
ithomas@iadr.org
International & American Association for Dental Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. UC San Diego researchers find cause of metabolic disease -- and possible cure
2. Researchers cut years from drug development with nanoscopic bead technology
3. New research explores relief for xerostomia cancer patients
4. 5 awarded ASTRO research grants
5. Lu receives grant from Research to Prevent Blindness organization
6. NIH expands food allergy research program
7. VCU first Virginia institution to join national network of academic research centers
8. Researcher targets gene regulators on link between arsenic, cancer
9. Researchers study relationship of oral cancers and periodontal disease
10. Report proposes new research agenda on pregnancy intentions of HIV-positive women
11. Alzheimers Research Spotlights Protein Tangles in Brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... Wright & Schulte LLC has filed a DePuy Pinnacle ... Johnson & Johnson, on behalf of an Ohio man who ... DePuy Pinnacle hip replacement and had to undergo revision surgery ... DePuy hip lawsuit was filed July 7, 2014, in the ... where DePuy Pinnacle Hip lawsuit litigation is underway . ...
(Date:7/12/2014)... Doylestown Hospital recently conducted an interview with Dr. ... Paddock tackles topics including main men's health concerns, ... than men, and testosterone replacement therapy, among others. In ... on Doylestown Hospital’s website, Dr. Brad Paddock says, “A ... you notice pain, bulging, or asymmetry in your lower ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 Utah Valley ... of startups, with awards being bestowed to companies in ... Utah’s outstanding entrepreneur community with recognition for new ideas ... model with incoming revenue. , 25 Under 5 highlights ... state that are under 5 years old. Award recipients ...
(Date:7/12/2014)... 2014 A recent article released by Seattle's ... of suggestions for those seeking cosmetic surgical procedures in ... approaching and the heat begins to enliven the rainy Pacific ... clothing, realizing that they didn’t work out as much during ... cause a sudden surge of people eager to look their ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 Wright & Schulte ... clients in Just For Men Lawsuits (case #59776/2014), announces ... consumers of reports that allege the popular hair dye, Just ... burns to their face, neck and other areas. In addition ... For Men chemical burns , the advertisements being run by ...
Breaking Medicine News(10 mins):Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 3Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 5Health News:Ivyland Medical Center’s Dr. Brad Paddock Offers Tips for Men’s Health 2Health News:SquareHook is Recognized for UVEF 25 Businesses Under 5 Years-Watch Out 2Health News:Best Summer Cosmetic Surgeries Revealed in Article By Seattle Plastic Surgeon 2Health News:Just for Men Lawsuit News: TV Campaign Launched by Wright & Schulte LLC to Inform Consumers of the Alleged Association between the Popular Hair Dye and Chemical Burns 2Health News:Just for Men Lawsuit News: TV Campaign Launched by Wright & Schulte LLC to Inform Consumers of the Alleged Association between the Popular Hair Dye and Chemical Burns 3Health News:Just for Men Lawsuit News: TV Campaign Launched by Wright & Schulte LLC to Inform Consumers of the Alleged Association between the Popular Hair Dye and Chemical Burns 4
... Interest Group to Enable an Internationally Interoperable ... ... Fla., Feb. 22 Liberty Alliance, the global,identity consortium working ... worldwide, today announced the launch of a,global public forum formed ...
... HIMSS ... - Booth 1835 -, ... excited to announce the continuing growth and maturation,of its Internet-based health ... Health Information Initiative has implemented the,Community MOMENT OF CARE(R) within Miami, ...
... scientists from the University Paris Descartes has solved the ... resistance to multiple types of antibiotics, according to a ... new clues as to how bacteria adapt to resist ... this defense mechanism. , Frdric Dardel and colleagues ...
... concerns about the dangers of kava and the effects ... as the US Food and Drug Administration and Australia,s ... kava and kava products. , Originally from Fiji, ... of Pharmacy at the University of Sydney, Australia, had ...
... of Denver study shows a curriculum-based bullying prevention program reduced ... in the study control group. , Jeffrey M. Jenson and ... of Social Work studied more than 1,100 students in 28 ... exposed to a bullying prevention program called Youth Matters (YM). ...
... their European counterparts, due in part to a higher rate ... in the United States, according to a study presented at ... to European men, U.S. men had 61 percent higher odds ... the odds of stroke as European women. , Most of ...
Cached Medicine News:Health News:Global Interoperability and Patient Privacy Focus of New Liberty Alliance Health Identity Management Group 2Health News:Cogon Systems, Inc. Supports the Formation of Virtual Health Communities with its Community MOMENT OF CARE(R) 2Health News:University of Sydney researchers find new evidence linking kava to liver damage 2Health News:University of Denver bullying victimization study 2Health News:Stroke more prevalent in United States than in Europe 2Health News:Stroke more prevalent in United States than in Europe 3
(Date:7/10/2014)... 10, 2014  The U.S. Department of Health and ... University Hospitals (UH) Case Medical Center Seidman Cancer Center ... aimed at improving care for patients with complex cancer. ... will test a unique model developed at UH to ... significant comorbidities, or demonstrated need for high health care ...
(Date:7/10/2014)... , July 10, 2014 Integrated Silicon ... in advanced memory and analog IC solutions, today announced ... Thursday, July 24, 2014, at 7:00 a.m. Pacific Time ... results for the fiscal 2014 third quarter ended June ... via telephone, dial 1-888-556-4997 before 6:50 a.m. Pacific time ...
(Date:7/10/2014)... 2014 Yesterday, former Congressman Patrick ... manufacturing facility. Rep. Kennedy and Dick Moberg ... cutting-edge research in neurological disease and treatment. ... advocate, Garen Staglin , created One Mind, ... changes that will radically accelerate the development and ...
Breaking Medicine Technology:University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2
... Greenville, SC, announced today that its Glucommander™ 2.0 Enterprise software ... 2 - 17. Glytec,s Glucommander was the first insulin dosing ... it is the only company to achieve specific ... company cleared to offer this technology to hospitals caring for ...
... OLATHE, Kan., May 21, 2012  BD (Becton, Dickinson and ... medical technology company, and Heart to Heart International, a ... their second joint volunteer initiative to strengthen healthcare in ... the world will build upon the progress made by ...
Cached Medicine Technology:Glytec Adds Pediatric Insulin Dosing to its IV and SubQ FDA Clearances 2BD and Heart to Heart International Collaborate on Second Volunteer Service Trip to Help Improve Healthcare in Haiti 2BD and Heart to Heart International Collaborate on Second Volunteer Service Trip to Help Improve Healthcare in Haiti 3
Transcranial vascular DWL doppler....
... powerful automated system capable of handling any ... user-programmable test protocols to begin a fully ... not included in the comprehensive list of ... the Doppler, PVR and PPG instrument modes. ...
Scoliosis Devices....
The CD Horizon Legacy Spinal System is part of the CD Horizon Spinal System designed for use in small stature patients. The posterior implants (hook and screws) are designed to fit patients in the ra...
Medicine Products: