Navigation Links
New research finds evidence of charitable behavior in bacteria
Date:9/1/2010

Researchers from the Wyss Institute for Biologically Inspired Engineering at Harvard and from Boston University have discovered that charitable behavior exists in one of the most microscopic forms of lifebacteria. Their findings appear in the current issue of Nature.

In studying the development of antibiotic-resistant strains of bacteria, the researchers found that the populations most adept at withstanding doses of antibiotics are those in which a few highly resistant isolates sacrifice their own well being to improve the group's overall chance of survival.

This bacterial altruism results when the most resistant isolates produce a small molecule called indole.

Indole acts as something of a steroid, helping the strain's more vulnerable members bulk up enough to fight off the antibiotic onslaught. But while indole may save the group, its production takes a toll on the fitness level of the individual isolates that produce it.

"We weren't expecting to find this," said lead investigator James J. Collins, Ph.D., professor of Biomedical Engineering at Boston University, a core faculty member of the Wyss Institute, and a Howard Hughes Medical Institute investigator. "Typically, you would expect only the resistant strains to survive, with the susceptible ones dying off in the face of antibiotic stress. We were quite surprised to find the weak strains not only surviving, but thriving."

The findings also shed new light on the level of complexity and heterogeneity within bacterial strains. Until now, it was assumed that the overall resistance level of any given population was reflected in each of its isolates. Instead, Collins and his team found that dramatic differences can exist within a single population with some bacteria showing exceptional resistance and some almost none, not unlike cancer cells in humans.

The fact that the full complexity of bacteria strains can now be more accurately understood has significant ramifications for the medical community. "Now, when we measure the resistance in a population, we'll know that it may be tricking us," said Collins. "We'll know that even an isolate that shows no resistance can put up a stronger battle against antibiotics thanks to its buddies."

Collins is a founder of the field of synthetic biology, an area of research that combines science and engineering to construct new biological circuits that can reprogram organisms, particularly bacteria, to perform desired tasks, much like we program computers now.

His research at Boston University has also led to the development of a new class of medical devices being developed at the Wyss Institute, including vibrating insoles that help reduce falls among elderly users and normalize the gait of children with cerebral palsy.

"The Wyss Institute was founded on the premise that by breaking down institutional barriers and bringing together some of the world's top minds in science and engineering, we could accelerate transformative discovery," said Donald E. Ingber, M.D., Ph.D., Founding Director of the Wyss Institute. "I'm proud to say that the research being done by Dr. Collins is a great example of how this vision is beginning to play out."


'/>"/>

Contact: Mary Tolikas
mary.tolikas@wyss.harvard.edu
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever ... Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation ... as home to some of the world’s leading providers of cereal and other breakfast ...
(Date:6/25/2016)... ... 2016 , ... Experts from the American Institutes for Research ... June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR experts ... planning, healthcare costs and patient and family engagement. , AIR researchers will be ...
(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
(Date:6/24/2016)... San Francisco, CA (PRWEB) , ... June 24, ... ... at CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has ... , self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Collagen Matrix, Inc., ("Collagen ... and manufacturing of collagen and mineral based medical ... that Bill Messer has joined the ... further leverage the growing portfolio of oral surgery, ... Bill joins the Collagen Matrix executive team ...
(Date:6/24/2016)... , June 24, 2016 ... the "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" ... In-Mold Electronics, Smart Skin, Structural ... Structural electronics involves electronic and/or ... protective structures, replacing dumb structures such as vehicle ...
(Date:6/24/2016)... Research and Markets has announced the ... Tests" report to their offering. ... The World Market for Companion Diagnostics covers the ... analysis in the report includes the following: ... Kits) by Region (N. America, EU, ROW), 2015-2020 , ...
Breaking Medicine Technology: