Navigation Links
New research finds evidence of charitable behavior in bacteria
Date:9/1/2010

Researchers from the Wyss Institute for Biologically Inspired Engineering at Harvard and from Boston University have discovered that charitable behavior exists in one of the most microscopic forms of lifebacteria. Their findings appear in the current issue of Nature.

In studying the development of antibiotic-resistant strains of bacteria, the researchers found that the populations most adept at withstanding doses of antibiotics are those in which a few highly resistant isolates sacrifice their own well being to improve the group's overall chance of survival.

This bacterial altruism results when the most resistant isolates produce a small molecule called indole.

Indole acts as something of a steroid, helping the strain's more vulnerable members bulk up enough to fight off the antibiotic onslaught. But while indole may save the group, its production takes a toll on the fitness level of the individual isolates that produce it.

"We weren't expecting to find this," said lead investigator James J. Collins, Ph.D., professor of Biomedical Engineering at Boston University, a core faculty member of the Wyss Institute, and a Howard Hughes Medical Institute investigator. "Typically, you would expect only the resistant strains to survive, with the susceptible ones dying off in the face of antibiotic stress. We were quite surprised to find the weak strains not only surviving, but thriving."

The findings also shed new light on the level of complexity and heterogeneity within bacterial strains. Until now, it was assumed that the overall resistance level of any given population was reflected in each of its isolates. Instead, Collins and his team found that dramatic differences can exist within a single population with some bacteria showing exceptional resistance and some almost none, not unlike cancer cells in humans.

The fact that the full complexity of bacteria strains can now be more accurately understood has significant ramifications for the medical community. "Now, when we measure the resistance in a population, we'll know that it may be tricking us," said Collins. "We'll know that even an isolate that shows no resistance can put up a stronger battle against antibiotics thanks to its buddies."

Collins is a founder of the field of synthetic biology, an area of research that combines science and engineering to construct new biological circuits that can reprogram organisms, particularly bacteria, to perform desired tasks, much like we program computers now.

His research at Boston University has also led to the development of a new class of medical devices being developed at the Wyss Institute, including vibrating insoles that help reduce falls among elderly users and normalize the gait of children with cerebral palsy.

"The Wyss Institute was founded on the premise that by breaking down institutional barriers and bringing together some of the world's top minds in science and engineering, we could accelerate transformative discovery," said Donald E. Ingber, M.D., Ph.D., Founding Director of the Wyss Institute. "I'm proud to say that the research being done by Dr. Collins is a great example of how this vision is beginning to play out."


'/>"/>

Contact: Mary Tolikas
mary.tolikas@wyss.harvard.edu
Wyss Institute for Biologically Inspired Engineering at Harvard
Source:Eurekalert

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/13/2017)... ... ... “America On The Brink”: the Christian history of the United States and the loss ... author, William Nowers. Captain Nowers and his wife, Millie, have six children, ten ... the Navy. Following his career as a naval aviator and carrier pilot, he ...
(Date:10/12/2017)... ... 2017 , ... The company has developed a suite of ... authorities worldwide. From Children’s to Adults 50+, every formula has been developed by ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, Preservative ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: ... develop to enable prevention of a major side effect of chemotherapy in children. ... pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a dose ...
(Date:10/12/2017)... ... October 12, 2017 , ... On Saturday, October 21, the ... – Miles by Moonlight to raise money for the American Heart Association Heart Walk. ... , Teams will work together to keep their treadmills moving for 5 hours. Treadmills ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
(Date:10/4/2017)... 2017 OBP Medical , a ... devices, today announced regulatory approval from ... Agência Nacional de Vigilância Sanitária (ANVISA)) to market ... retractor with integrated LED light source and smoke ... exposure of a tissue pocket or cavity during ...
(Date:10/2/2017)... Halo Labs announces the European launch of their new ... at MIBio 2017 in Cambridge, U.K on ... in biopharmaceutical samples with unprecedented speed and sensitivity while using far ... Membrane Imaging. ... particle analysis system ...
Breaking Medicine Technology: