Navigation Links
New research explores relief for xerostomia cancer patients
Date:7/14/2010

Barcelona, Spain Today during the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain, presenting author S. Pradhani, University of Delaware, Newark, USA, will present an abstract titled "Salivary Acinar Cells Regenerate Functional Glandular Structures in Modified Hydrogels."

The goal of this research was to create an ECM modified hyaluronic acid (HA) based hydrogel culture system that allows for the growth and differentiation of salivary acinar cells into functional acini-like structures capable of secreting large amounts of protein and fluid unidirectionally. Xerostomia, a condition resulting from irradiation of the head and neck, affects more than 40,000 cancer patients each year in the United States. According to this research, these patients will greatly benefit from the development of a functional implantable artificial salivary gland.

In this study, an IRB approved protocol was established and salivary gland tissue was obtained from patients undergoing head and neck surgery. Tissue specimen was dissociated to obtain acinar enriched cultures. Biomarker studies with the salivary enzyme, α-amylase and tight junction proteins such as zonula occludens-1 and E-cadherin, confirmed the phenotype of these cells. Acinar cells were seeded on HA-based hydrogels to obtain lobular structures with central apoptosing cells and lumen.

An HA-based hydrogel system was developed to aid the differentiation of acinar cells into lobular acini-like structures. Functionality of these structures was demonstrated by the use of neurotransmitters that enhance their fluid and protein secretion pathways. Future experiments will involve implantation of these hydrogels in animal models to test their functionality in vivo.

This is a summary of abstract #539, "Salivary Acinar Cells Regenerate Functional Glandular Structures in Modified Hydrogels," to be presented by S. Pradhani at 11:45 a.m., Thursday, July 15, 2010 in Room 133 of the Centre Convencions Internacional Barcelona, Spain during the 88th General Session & Exhibition of the International Association for Dental Research.


'/>"/>

Contact: Ingrid Thomas
ithomas@iadr.org
International & American Association for Dental Research
Source:Eurekalert

Related medicine news :

1. 5 awarded ASTRO research grants
2. Lu receives grant from Research to Prevent Blindness organization
3. NIH expands food allergy research program
4. VCU first Virginia institution to join national network of academic research centers
5. Researcher targets gene regulators on link between arsenic, cancer
6. Researchers study relationship of oral cancers and periodontal disease
7. Report proposes new research agenda on pregnancy intentions of HIV-positive women
8. Alzheimers Research Spotlights Protein Tangles in Brain
9. HIV care providers and researchers applaud release of national HIV/AIDS strategy
10. Researchers envision better disease surveillance to improve public health
11. Shao wins grant from Research to Prevent Blindness organization for dry eye research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2016)... MD (PRWEB) , ... February 08, 2016 , ... ... is excited to share this important news! AHCC and the Home Health and ... Coding Clinic, CMS' designee for official ICD coding guidance and clarifications, to address ...
(Date:2/8/2016)... ... 2016 , ... The schedule is now online for the largest ... which is being held May 25-29 at the Loews Chicago O’Hare Hotel, continues to ... causes of chronic illness in children. , Very recent articles have cited 1 child ...
(Date:2/7/2016)... ... 2016 , ... HealthSmart Holdings, Inc. announced today the launch ... and information to lower the costs, and increase the impact of their healthcare ... healthcare benefits by as much as 22%:, + Price and quality transparency, ...
(Date:2/6/2016)... ... ... With the FCPX LUT: Summer pack from Pixel Film Studios, ... is a Lookup Table that contains a mathematical formula for modifying an image. The ... manipulating each pixel, LUT's can change each color range differently, it gives the user ...
(Date:2/5/2016)... ... February 05, 2016 , ... Love is in the ... a variety of colors, assortments and packaging. This staple for Valentine’s Day is a ... location. , For Valentine’s Day, not only are long-stem roses available, but also ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)...  Redwood Scientific Technologies, Inc. announced today the development ... women balance their hormones. This product will be featuring ... Jason Cardiff , President and CEO. "I am proud ... millions of women across the country and around the ... Our research and development team is confident that through ...
(Date:2/5/2016)... , Feb. 5, 2016  ivWatch, a medical devices company, ... STEM Award granted by Governor Terry McAuliffe,s office. ... on February 25th at an event to be held at ... STEM award honors professionals and business that have made significant ... Logo - http://photos.prnewswire.com/prnh/20160205/330117LOGO ...
(Date:2/5/2016)... in Alabama seeking prostate care with ... have to travel out of state. Vituro Health ... of Alabama to provide a total prostate management program ... Alabama is known throughout the ... using many different modalities. They are the largest and one ...
Breaking Medicine Technology: