Navigation Links
New research explores relief for xerostomia cancer patients

Barcelona, Spain Today during the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain, presenting author S. Pradhani, University of Delaware, Newark, USA, will present an abstract titled "Salivary Acinar Cells Regenerate Functional Glandular Structures in Modified Hydrogels."

The goal of this research was to create an ECM modified hyaluronic acid (HA) based hydrogel culture system that allows for the growth and differentiation of salivary acinar cells into functional acini-like structures capable of secreting large amounts of protein and fluid unidirectionally. Xerostomia, a condition resulting from irradiation of the head and neck, affects more than 40,000 cancer patients each year in the United States. According to this research, these patients will greatly benefit from the development of a functional implantable artificial salivary gland.

In this study, an IRB approved protocol was established and salivary gland tissue was obtained from patients undergoing head and neck surgery. Tissue specimen was dissociated to obtain acinar enriched cultures. Biomarker studies with the salivary enzyme, α-amylase and tight junction proteins such as zonula occludens-1 and E-cadherin, confirmed the phenotype of these cells. Acinar cells were seeded on HA-based hydrogels to obtain lobular structures with central apoptosing cells and lumen.

An HA-based hydrogel system was developed to aid the differentiation of acinar cells into lobular acini-like structures. Functionality of these structures was demonstrated by the use of neurotransmitters that enhance their fluid and protein secretion pathways. Future experiments will involve implantation of these hydrogels in animal models to test their functionality in vivo.

This is a summary of abstract #539, "Salivary Acinar Cells Regenerate Functional Glandular Structures in Modified Hydrogels," to be presented by S. Pradhani at 11:45 a.m., Thursday, July 15, 2010 in Room 133 of the Centre Convencions Internacional Barcelona, Spain during the 88th General Session & Exhibition of the International Association for Dental Research.


Contact: Ingrid Thomas
International & American Association for Dental Research

Related medicine news :

1. 5 awarded ASTRO research grants
2. Lu receives grant from Research to Prevent Blindness organization
3. NIH expands food allergy research program
4. VCU first Virginia institution to join national network of academic research centers
5. Researcher targets gene regulators on link between arsenic, cancer
6. Researchers study relationship of oral cancers and periodontal disease
7. Report proposes new research agenda on pregnancy intentions of HIV-positive women
8. Alzheimers Research Spotlights Protein Tangles in Brain
9. HIV care providers and researchers applaud release of national HIV/AIDS strategy
10. Researchers envision better disease surveillance to improve public health
11. Shao wins grant from Research to Prevent Blindness organization for dry eye research
Post Your Comments:
(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work to ... “patient engagement.” The patient is doing more than filling out a survey; in many ... is an increasing emphasis in health care and research on the importance of active ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading Health and Nutrition ... the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly growing CBD market ... can be easily incorporated into liquid products, while reducing costs to end users. , ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that ... insurance companies have a waiver for care if the client has a cognitive impairment ... family pays for care, is often waived, so the benefits from their insurance start ...
(Date:10/13/2017)... Abilene, Texas (PRWEB) , ... October 13, 2017 , ... ... publication this week that explains one of the most popular and least understood books ... seems like cryptic and puzzling descriptions that have baffled scholars for centuries. Many have ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “America On The ... identity. “America On The Brink” is the creation of published author, William Nowers. ... great-grandchildren. As a WWII veteran, he spent thirty years in the Navy. ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: ... Consulting, LLC , and named its founder as Diplomat,s ... Tennessee , will operate under Diplomat ... service offerings for health care partners to include IT ... "In an interoperable world, technology delivers comprehensive ...
(Date:10/2/2017)... ORLANDO, Fla. , Oct. 2, 2017  AllianceRx ... services company formed by Walgreens and pharmacy benefit manager ... of its new brand, which included the unveiling of ... Fla. , as well as at a few ... introduces the new brand to patients, some of whom ...
(Date:10/2/2017)... The Rebound mobile app is poised to become ... tide of prescription drug addiction. The app empowers users to ... stepping down their dosage in a safe, controlled manner while ... the first 100,000 people to sign up will enjoy 3 ... ...
Breaking Medicine Technology: