Navigation Links
New research explores relief for xerostomia cancer patients
Date:7/14/2010

Barcelona, Spain Today during the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain, presenting author S. Pradhani, University of Delaware, Newark, USA, will present an abstract titled "Salivary Acinar Cells Regenerate Functional Glandular Structures in Modified Hydrogels."

The goal of this research was to create an ECM modified hyaluronic acid (HA) based hydrogel culture system that allows for the growth and differentiation of salivary acinar cells into functional acini-like structures capable of secreting large amounts of protein and fluid unidirectionally. Xerostomia, a condition resulting from irradiation of the head and neck, affects more than 40,000 cancer patients each year in the United States. According to this research, these patients will greatly benefit from the development of a functional implantable artificial salivary gland.

In this study, an IRB approved protocol was established and salivary gland tissue was obtained from patients undergoing head and neck surgery. Tissue specimen was dissociated to obtain acinar enriched cultures. Biomarker studies with the salivary enzyme, α-amylase and tight junction proteins such as zonula occludens-1 and E-cadherin, confirmed the phenotype of these cells. Acinar cells were seeded on HA-based hydrogels to obtain lobular structures with central apoptosing cells and lumen.

An HA-based hydrogel system was developed to aid the differentiation of acinar cells into lobular acini-like structures. Functionality of these structures was demonstrated by the use of neurotransmitters that enhance their fluid and protein secretion pathways. Future experiments will involve implantation of these hydrogels in animal models to test their functionality in vivo.

This is a summary of abstract #539, "Salivary Acinar Cells Regenerate Functional Glandular Structures in Modified Hydrogels," to be presented by S. Pradhani at 11:45 a.m., Thursday, July 15, 2010 in Room 133 of the Centre Convencions Internacional Barcelona, Spain during the 88th General Session & Exhibition of the International Association for Dental Research.


'/>"/>

Contact: Ingrid Thomas
ithomas@iadr.org
International & American Association for Dental Research
Source:Eurekalert

Related medicine news :

1. 5 awarded ASTRO research grants
2. Lu receives grant from Research to Prevent Blindness organization
3. NIH expands food allergy research program
4. VCU first Virginia institution to join national network of academic research centers
5. Researcher targets gene regulators on link between arsenic, cancer
6. Researchers study relationship of oral cancers and periodontal disease
7. Report proposes new research agenda on pregnancy intentions of HIV-positive women
8. Alzheimers Research Spotlights Protein Tangles in Brain
9. HIV care providers and researchers applaud release of national HIV/AIDS strategy
10. Researchers envision better disease surveillance to improve public health
11. Shao wins grant from Research to Prevent Blindness organization for dry eye research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has ... Yisrayl makes an astounding statement when he says that the entire Bible was written ... the current times so plainly that anyone should be able to see the time ...
(Date:2/24/2017)... ... 2017 , ... Congratulations to Head Over Heels’ elite gymnast ... Ms. Esparza qualified into this prestigious status after winning the Vault, Floor, ... Nevada. Frida is one of approximately 25 gymnasts in the nation who earns ...
(Date:2/23/2017)... ... February 23, 2017 , ... The Lymphoma Research Foundation (LRF) ... and serving the lymphoma community through a comprehensive series of education programs, outreach ... in Miami Beach to host its Swirl: Miami Wine Tasting Event on March ...
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... ... thought leadership , media relations, content marketing, social media management, corporate communications, ... clients already in the state and in nearby New Hampshire, Massachusetts and Canada, ...
(Date:2/23/2017)... ... February 23, 2017 , ... ERT, a ... today announced that Premier Research, a leading clinical development service provider, has selected ... becoming increasingly complex, due in part to an array of circumstances including the ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... NEW YORK , Feb. 23, 2017  Genesis ... HME Company. The announcement was made by Bill ... David Hartley and Nathan Feltman , ... of Genesis Healthcare Services, LLC. This ... nation,s largest provider of technology enabled durable medical equipment ...
(Date:2/23/2017)... -- Cogentix Medical, Inc. (NASDAQ: CGNT), a medical device company ... the urology market, will release financial results for the ... before the market open on Thursday, March 9, 2017. ... call and webcast to discuss its financial results the ... a.m. Eastern Time (10:00 a.m. Central Time). Darin ...
(Date:2/23/2017)... REDWOOD CITY, Calif., Feb. 23, 2017 Nevro Corp. ... innovative evidence-based solutions for the treatment of chronic pain, today ... ended December 31, 2016. 2016 Accomplishment & ... the full year 2016, an increase of 228% as reported, ... million for 2016, an increase of 612% over the prior ...
Breaking Medicine Technology: