Navigation Links
New research center to focus on cardiac safety and innovation
Date:11/11/2009

The University of Rochester Medical Center has announced the creation of a new center that will assist researchers studying the electrical activity of the heart with the goal of improving drug safety, understanding cardiac arrhythmias, and developing new electrocardiograph technologies. The Center for Quantitative Electrocardiology and Cardiac Safety funded by a $2.3 million grant from the National Institutes of Health brings together an international network of academic researchers, pharmaceutical and medical device companies, and government regulators.

"Cardiac toxicity is one of the leading causes of removal of drugs from the market," said University of Rochester biomedical engineer Jean-Philippe Couderc, Ph.D., the director of the new Center. "The goal of this initiative is to foster collaboration on an international scale and support research that will ultimately improve cardiac safety."

The new Center will focus on developing novel methods and new technologies to evaluate electrocardiographs (ECG) for the purposes of predicting cardiac arrhythmias. The Center's unique resources will help scientists better understand heart disease and determine whether or not experimental drugs are toxic to the heart. Sudden cardiac arrest is one of the leading causes of death and many of these incidents are drug-related either caused by the drugs themselves or because a drug triggered a predisposition to lethal cardiac arrhythmias.

In 2004, the Food and Drug Administration (FDA) launched the Critical Path Initiative, an effort to accelerate the process of bringing medical breakthroughs to patients while at the same time ensuring safety and reducing drug development costs. One of the goals of this initiative was to develop better ways to determine a drug's potential cardiac toxicity before it is brought to market. The FDA requires a thorough analysis of the impact of experimental drugs on cardiac activity, but it is acknowledged that current methods can be improved.

Last year, the FDA partnered with the University of Rochester to create an electronic database of ECG data to help foster research in this field. The Telemetric Holter Electrocardiograph Warehouse (THEW) which now forms the core of the new Center consists of thousands of recordings from individuals with cardiac arrhythmias, healthy volunteers, individuals with drug induced cardiac events, individuals participating in clinical trials, and rare cardiac events. This data comes from individuals who have worn cardiac monitoring devices to record their heart activity, usually for hours or days at a time.

This data will be provided to academic and private research organizations to help them design and validate new tools and methods to detect abnormal cardiac activity. They Center will also serve as a bridge between researchers and federal regulators to help facilitate the development of new technologies that can improve safety and reliability of information from clinical trials.

"The Center represents probably the first opportunity in the history of cardiac safety where data of this scale and value has been gathered together and made available to academic and industry researchers," said Couderc. "At the same time, these resources will help support a scientific network in which ideas and concept related to ECG technologies can be discussed and implemented with the input from representatives from the National Institutes of Health and the FDA."

The Center is an outgrowth of the University of Rochester's Heart Research Follow-Up Program which has been a leader in the science of heart arrhythmias for over 20 years. The program maintains an international registry of individuals with a rare inherited syndrome that is similar to drug induced cardiac events.

To date, the project has received ECG data from pharmaceutical companies Pfizer and Roche and Munich University in Germany. Academic research partners include the University of Minnesota, University of Utah, Masonic Medical Research Laboratory in Utica, New York, Stony Brook University, University of California San Francisco, Lariboisire Hospital in Paris, University of Milan, Eramus Medical Center in the Netherlands, University of Applied Sciences in Germany, Louis Pradel Hospital and INSA in Lyon, France, Lund University Hospital in Sweden, the Academy of Science of the Czech Republic, and the University of Zaragoza in Spain.


'/>"/>

Contact: Mark Michaud
mark_michaud@urmc.rochester.edu
585-273-4790
University of Rochester Medical Center
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... Texas (PRWEB) , ... March 23, 2017 , ... ... Command (USSOCOM) awarded Task Force Dagger Foundation the US Special Operations Command’s Patriot ... During the presentation, General Thomas thanked Task Force Dagger Foundation for its significant ...
(Date:3/23/2017)... ... March 23, 2017 , ... The Boulevard is honored to host Shriners ... events will be located in the Main West Entrance of The Boulevard (in front ... No appointment is necessary and each child with a parent or guardian will be ...
(Date:3/23/2017)... ... March 23, 2017 , ... News Advisory/Interview Opportunity , After six years of ... victory in Europe for public health and the environment and is calling on the ... research and the overwhelming support of European citizens, the European Union (EU) will, beginning ...
(Date:3/23/2017)... ... March 23, 2017 , ... “Wounded Woman Be Ye Healed-Passing ... Ye Healed-Passing On A Legacy” is the creation of published author, Desiree M Webb, ... grief ministry. She has been happily married to her husband, Paul, for over ...
(Date:3/23/2017)... ... March 23, 2017 , ... Ogden Clinic, the largest ... centric payment system, to expand its focus on patient care by providing an ... , “At Ogden Clinic, we are working to become a different type ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , Mar 23, 2017 Research and Markets ... 2017-2021" report to their offering. ... The global capillary electrophoresis market to grow ... The report, Global Capillary Electrophoresis Market 2017-2021, has been prepared ... The report covers the market landscape and its growth prospects over ...
(Date:3/23/2017)... -- Drug diversion is a significant contributing factor in ... new oral fluid monitoring test, announced today by ... detailed and actionable information to clinicians than urine ... patient safety, and help to identify drug diversion. ... Evaluation (CORE) system is the first patient-monitoring screening ...
(Date:3/23/2017)... 2017  A new genetic test has been ... individuals who carry HLA-B*15:02 and who ... potentially deadly side effect of certain medications used ... HLA-B*15:02 is strongly associated with life-threatening ... and toxic epidermal necrolysis in patients treated with ...
Breaking Medicine Technology: