Navigation Links
New regulatory circuit identified for aggressive, malignant brain tumor
Date:4/7/2008

Research using a newly developed algorithm has significantly advanced understanding of the molecular events associated with the most common primary brain tumor in adults, human glioblastoma (GBM). The research, published by Cell Press in the April issue of the journal Cancer Cell, validates known genetic aberrations and identifies events not previously linked with GBM, thereby elucidating new directions for potential therapeutic strategies.

GBM is a devastating neurological cancer that is characterized by widespread invasion, robust angiogenesis and a stubborn resistance to conventional and targeted treatments. Previous research has implicated a long and highly complex list of genes in GBM pathogenesis, emphasizing the need for a systemic prioritization that would separate relevant target genes from bystanders and provide detailed knowledge of the complex interactions between multiple disrupted genes and downstream targets.

Dr. Lynda Chin from Dana-Farber Cancer Institute, Dr. Cameron Brennan from Memorial Sloan-Kettering Cancer Center and their colleagues used a high-resolution genome topography scan (GTS) algorithm to both define and rank the patterns of genomic alterations associated with GBM in primary samples and cell lines. Using this new methodology, the researchers discovered an unanticipated co-deletion pattern among closely related INK genes in the GBM oncogenome.

Specifically, the researchers identified a frequent co-deletion of p18INK4C and p16INK4A, a pattern unique to glioblastoma. Functional reconstitution of p18INK4C in GBM cells lacking both p16INK4A and p18INK4C resulted in impaired cell cycle progression and tumorigenic progression. Depletion of p18INK4C in p16INK4A-deficient primary glial cells or established GBM cells enhanced tumorigenicity while acute suppression of p16INK4A in primary glial cells induced an increase in p18INK4C. These results uncover an unanticipated tumor suppressor role for p18INK4C in human GBM wherein it functions cooperatively with other INK4 family members to constrain inappropriate glial cell proliferation, concludes Dr. Chin.

This study also demonstrates that GTS can address one critical need in the development of a functional map of GBM genetic targets: namely, to prioritize those genomic alterations that are likely to be of importance from among those that are more likely to be bystanders of the cancer process, offers Dr.Brennan. Downstream functional validation of high probability candidates should yield novel GBM genes and potential targets for therapeutic intervention.


'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
603-591-8797
Cell Press
Source:Eurekalert

Related medicine news :

1. Biopure Receives Comment Letter From U.K. Regulatory Body on Marketing Application for Hemopure(R)
2. Alsius Corporation Receives Regulatory Approval in China and Mexico
3. InnerPulse, Inc. Appoints Elsa Chi Abruzzo as Vice-President of Regulatory and Quality Affairs
4. CSHL scientists discover new details of a gene-regulatory network governing metabolism
5. Legislative and Regulatory Outlook - 2009 and Beyond for Pharma, Biotech Players
6. Cipher provides CIP-TRAMADOL ER regulatory update
7. Mybank Goes Live With Misys Equation to Support Rapid Growth and Meet Future Regulatory Requirements
8. Mannatech Names New VP of Regulatory Affairs, Quality Assurance
9. Cardiome And Astellas Announce Regulatory Update
10. CuraGen and TopoTarget Report Belinostat Results Presented at ASH and Provide Regulatory Update Following End-of-Phase II Meeting with FDA
11. Medarex to Receive Milestone Payment for Submission of Regulatory Applications Requesting Approval of Ustekinumab (CNTO 1275) for Treatment of Psoriasis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... ... New Jersey: This year marks Children’s Specialized Hospital ’s 125th anniversary of helping ... hospital has themed the milestone “Hats Off” and kicked off the yearlong celebration at ... 21, at Johnson Park in Piscataway, New Jersey. , “Hats Off” is ...
(Date:5/24/2016)... New York, NY (PRWEB) , ... May 24, ... ... of rehabilitative treatment for physical disease or injury that focuses on repairing the ... surgery. , With an emphasis on functional restoration, NYDNRehab began providing treatments ...
(Date:5/24/2016)... ... May 24, 2016 , ... Growing in popularity, more ... more gluten-free products are available and easily accessible. Whether someone chooses to cut gluten ... to a certain diet, King Kullen Grocery stocks their shelves with many different gluten-free ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... a wellness specialist for forty years and a trainer for Ageless Grace ( ... Hour Radio Talk Show on May 16, 2016. , Formerly a Northwestern University ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... Dominican Republic on September 21, 2016. Dr. Gerard, who holds a Doctorate of ... a not-for-profit organization promoting health and wellness in Third World countries where resources ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 2016 Open Access Journal ... Elsevier , a world-leading provider of ... announced the launch of Clinical Neurophysiology ... focuses on clinical practice issues in clinical neurophysiology. The ... normal values and didactic reviews. It is an official ...
(Date:5/23/2016)... PUNE, India , May 23, 2016 ... is spread across 163 pages, profiles 12 companies and ... 280 tables and figures on the industry and its ... study that is comprehensive in nature, details the current ... of the industry including definitions, classifications, applications and industry ...
(Date:5/23/2016)... 23, 2016 Clarifying Vision - ... Monitoring, and Vision Care What can be ... going to grow at the fastest rates? This ... assessing data, trends, opportunities and prospects. ... Discover the most lucrative areas in the industry and ...
Breaking Medicine Technology: