Navigation Links
New regions of genetic material are involved in the development of colon cancer
Date:7/23/2014

Most research on human cancer genes have been focused on the regions of the coding genome (exons) that are to be translated in the form of amino acids thus proteins. But just before each gene, there is a regulatory region or activator which controls the expression and activity of the adjacent gene. Until now, very little was known of the role exerted such DNA fragment in tumor development.

An article published today in Nature in collaboration with the group of Manel Esteller, Director of Epigenetics and Cancer Biology, Bellvitge Biomedical Research Institute (IDIBELL), ICREA researcher and Professor of Genetics at the University of Barcelona, shows that these regions are also altered in cancer.

"The results of the Nature study reveal that regulatory regions preceding the gene as such, are variable, can mutate and be chemically modified, such as with DNA methylation in the cells of the tumor transformation" declares Esteller, co -author of the study.

"By studying a large cohort of patients with colon cancer, a tumor type very common in our society, we realized that these areas of control genes were so injured as genes and caused an altered function of the target gene. Our work shows a new list of genes involved in cancer development, hitherto unknown, which are abhorrent simply by poor control of these promoter regions. "

These findings may have a profound importance in understanding the biology of cancer and stress the need not only to focus on the region of the classical genes (exome), but also wonder about the regulatory regions of oncogenes and tumor suppressor genes .


'/>"/>

Contact: Arantxa Mena
amena@idibell.cat
0034-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers Map Brain Regions Linked to Intelligence
2. Certain Genetic Regions May Be Tied to Osteoporosis
3. Scientists ID New Gene Regions Linked to Type 2 Diabetes
4. Regions vary in paying prisoners to participate in research
5. Imaging study examines effect of fructose on brain regions that regulate appetite
6. Brains of Fetuses Build a Bridge Between Regions, Images Show
7. Regions Hospital Reports Success with BESLER’s BVerified(SM) Suite of Revenue Recovery Solutions
8. Hound.com Finds Jobs in South Atlantic and South West Central Regions Mirroring Current Employment Trends
9. Increasing construction in APAC and EMEA regions are the main drivers for its increasing consumption globally for Concrete Admixtures - New Report by MarketsandMarkets
10. Higher cancer incidences found in regions near refineries and plants that release benzene
11. Growing share of HIV/AIDS burden shifts to changing group of regions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... , ... 10 Best Water is excited to announce a new ... that topped the list as a result of their commitment to offering clients creative, ... Tibet 5100, a top notch water company that specializes in providing the public with ...
(Date:2/10/2016)... ... February 10, 2016 , ... Ongoing news of the ravages of traumatic ... to conduct a survey that takes a closer look at cases of TBI being ... and causes of TBI among the aging population, and identifies the challenges associated with ...
(Date:2/10/2016)... ... ... Gout is like no other joint pain. It strikes suddenly, like flicking on ... redness. It is triggered by the crystallization of uric acid within the joints. It ... to the February 2016 issue of Harvard Men's Health Watch. , The large joint ...
(Date:2/10/2016)... ... February 10, 2016 , ... AHRA: The Association ... inspirational speaker Jan Fox will serve as keynote speaker at the organization’s 2016 ... with tools to more effectively communicate with their own organizational staff and leadership. ...
(Date:2/10/2016)... ... February 10, 2016 , ... A ... Ohio Safety Congress and Expo event March 9-11, 2016. Hosted by Ohio's Bureau ... Center. , As the longest running and largest worker's compensation event in ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Israel , Feb. 11, 2016  Galmed Pharmaceuticals Ltd. ... company focused on the development of a once-daily, oral ... that its Chief Medical Officer, Dr. Maya Halpern ... Galmed as Chief Medical Officer and from its Board ... to her reaching retirement age. Allen Baharaff ...
(Date:2/11/2016)... Hungary , Feb. 11, 2016 ... the unmet medical need of pulmonary and respiratory diseases ... The program focusing on COPD and asthma patients show ... --> --> Upper ... healthcare problems in the developed world and reached epidemic ...
(Date:2/11/2016)... February 11, 2016 ,   ... EUR 1,377.2m  Adjusted EBITDA climbs to EUR 277.9m   ... 3.41  Proposed dividend of EUR 0.85 per share (2014: ... tubing business and refinancing successfully completed  Approximately 9% ... organic basis  Adjusted EBITDA expected for 2016 at ...
Breaking Medicine Technology: