Navigation Links
New regions of genetic material are involved in the development of colon cancer
Date:7/23/2014

Most research on human cancer genes have been focused on the regions of the coding genome (exons) that are to be translated in the form of amino acids thus proteins. But just before each gene, there is a regulatory region or activator which controls the expression and activity of the adjacent gene. Until now, very little was known of the role exerted such DNA fragment in tumor development.

An article published today in Nature in collaboration with the group of Manel Esteller, Director of Epigenetics and Cancer Biology, Bellvitge Biomedical Research Institute (IDIBELL), ICREA researcher and Professor of Genetics at the University of Barcelona, shows that these regions are also altered in cancer.

"The results of the Nature study reveal that regulatory regions preceding the gene as such, are variable, can mutate and be chemically modified, such as with DNA methylation in the cells of the tumor transformation" declares Esteller, co -author of the study.

"By studying a large cohort of patients with colon cancer, a tumor type very common in our society, we realized that these areas of control genes were so injured as genes and caused an altered function of the target gene. Our work shows a new list of genes involved in cancer development, hitherto unknown, which are abhorrent simply by poor control of these promoter regions. "

These findings may have a profound importance in understanding the biology of cancer and stress the need not only to focus on the region of the classical genes (exome), but also wonder about the regulatory regions of oncogenes and tumor suppressor genes .


'/>"/>

Contact: Arantxa Mena
amena@idibell.cat
0034-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers Map Brain Regions Linked to Intelligence
2. Certain Genetic Regions May Be Tied to Osteoporosis
3. Scientists ID New Gene Regions Linked to Type 2 Diabetes
4. Regions vary in paying prisoners to participate in research
5. Imaging study examines effect of fructose on brain regions that regulate appetite
6. Brains of Fetuses Build a Bridge Between Regions, Images Show
7. Regions Hospital Reports Success with BESLER’s BVerified(SM) Suite of Revenue Recovery Solutions
8. Hound.com Finds Jobs in South Atlantic and South West Central Regions Mirroring Current Employment Trends
9. Increasing construction in APAC and EMEA regions are the main drivers for its increasing consumption globally for Concrete Admixtures - New Report by MarketsandMarkets
10. Higher cancer incidences found in regions near refineries and plants that release benzene
11. Growing share of HIV/AIDS burden shifts to changing group of regions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... November 22, 2014 In order to provide ... promotion of cocktail party dresses. The business knows that a ... social occasions. , Now, the party dresses supplier’s ... 70% off. As the leading company in fashion industry, LunaDress ... outfit for every customer. So it always raises the professional ...
(Date:11/22/2014)... Domestic farmgate milk and dairy ... due to a fall in demand for ... amid the global financial crisis. However, these declines ... dairy manufacturers on the international scene. Strong growth ... growth, primarily due to supply constraints in some ...
(Date:11/22/2014)... has been a historical time for Angeldress.co.uk, an excellent wedding ... some renowned review websites. Recently, the company has added to ... of wonderful sexy wedding dresses to its website. At the ... to an 80% discount on any order over GBP 149. ... dress at Angeldress.co.uk, which has garnered a hard core of ...
(Date:11/22/2014)... The Sports Conflict Institute is pleased to ... team of conflict resolution professionals. Baroff comes to SCI as ... has over 30 years experience as an arbitrator, educator, and ... to connect with SCI and bring my conflict resolution skills ... with a complete sports focus,” says Baroff. , “Roy has ...
(Date:11/22/2014)... Washington, DC (PRWEB) November 22, 2014 ... its monthly Tech Report , which features the ... Sofastaii, a technology expert and reporter for NewsWatch, conducted ... can easily improve the flavor of your water. , ... are everywhere. It’s important that everything is done to ...
Breaking Medicine News(10 mins):Health News:LunaDress Unveils Fabulous Cocktail Party Dresses 2Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Butter and Dairy Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:Sexy Wedding Dresses with Special Discounts Launched by Angeldress.co.uk 2Health News:SCI Announces New Team Member Roy Baroff 2Health News:SCI Announces New Team Member Roy Baroff 3Health News:An Easy Home Solution to Get Better Tasting Water was Featured on NewsWatch Television on October 30, 2014 2
... cent OBC quota in Central educational institutions, Union Health ... was a media creation // and that the ... ,'The resistance was all by the media,' Ramadoss ... had supported the government proposal, he said 'This is ...
... more likely to suffer from cancer and die from it, ... at Israel's //Haifa University suspect that cancers are most likely ... II. ,The researchers looked at the incidence and ... European origin - comparing those who emigrated from Europe before ...
... trying to reattach the foot of a four-year-old boy. The boy ... father // riding over him on a lawn mover. ... a lawn mower when the boy came up unexpectedly behind him. ... into reverse and accidentally ran over the boy's leg. It was ...
... women to donate their eggs for research as they ... // which they say would hopefully find new treatments ... disease. ,They want to extract embryonic stem ... patients with diabetes or neurodegenerative disease, according to Nature ...
... antibiotics for three days rather than the usual concept of ... of common pneumonia // . ,According to researchers ... antibiotic-resistant bacteria, ,Lead researcher Dr. Jan M Prins, ... in Amsterdam said,’The question is how long you should treat ...
... conducted by Dr Taraneh Dean of the University of Portsmouth and ... restricted // in their food intakes because their parents ... team found that found that 54 per cent of a sample ... their parents were convinced that such food items initiated ...
Cached Medicine News:Health News:Pneumonia Effectively Treated with Short-Term Antibiotic Course 2
(Date:11/21/2014)... UNION CITY, Calif. , Nov. 21, 2014 /PRNewswire/ ... products company manufacturing point-of-care instruments and consumables for the ... lab services to the veterinary and research markets in ... the completion of a stock purchase agreement to acquire ... United Kingdom based distribution organization. The ...
(Date:11/21/2014)... 21, 2014 Clementia Pharmaceuticals, ... Agency (EMA) has granted Orphan Medicinal Product ... candidate, for the treatment of fibrodysplasia ossificans ... disabling genetic disease characterized by painful, recurrent ... new abnormal bone formation. This process, known ...
(Date:11/21/2014)... YORK , Nov. 20, 2014  Market research firm ... the "Year of The Buy, in the medical device ... for medical devices will produce just 3% growth this ... actions, including acquisitions of product lines and entrance by ... annual survey of medical devices, The Global Market ...
Breaking Medicine Technology:Abaxis Acquires UK-based Distribution Organization 2Abaxis Acquires UK-based Distribution Organization 3Abaxis Acquires UK-based Distribution Organization 4Clementia Pharmaceuticals Receives EMA Orphan Medicinal Product Designation for Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva 2Clementia Pharmaceuticals Receives EMA Orphan Medicinal Product Designation for Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva 3Kalorama: 2014 The "Year of The Buy" in Medical Device Industry 2
... NEW YORK, Sept. 12, 2011 A revolutionary new ... other technology - - the VivoSight® Optical Coherence ... to dermatologists in the U.S. for the first time. ... skin surface instantly, providing additional information which will allow ...
... Sept. 12, 2011 Intarcia Therapeutics, Inc. announced ... ITCA 650 (DUROS® subcutaneous continuous delivery of exenatide) ... the 47th Annual Meeting of the European Association ...  All three presentations are scheduled for Wednesday, September ...
Cached Medicine Technology:Revolutionary Device for Use in Detecting Non-Melanoma Skin Cancer in Real Time, Alleviates Patient Stress, Can Reduce Invasive Biopsy 2Revolutionary Device for Use in Detecting Non-Melanoma Skin Cancer in Real Time, Alleviates Patient Stress, Can Reduce Invasive Biopsy 3Revolutionary Device for Use in Detecting Non-Melanoma Skin Cancer in Real Time, Alleviates Patient Stress, Can Reduce Invasive Biopsy 4Intarcia Announces Presentations of Three Clinical Abstracts at the 47th Annual Meeting of the European Association for the Study of Diabetes 2Intarcia Announces Presentations of Three Clinical Abstracts at the 47th Annual Meeting of the European Association for the Study of Diabetes 3Intarcia Announces Presentations of Three Clinical Abstracts at the 47th Annual Meeting of the European Association for the Study of Diabetes 4
... Parachute Tissue Anchor allows one step fixation of ... for arthroscopic knotless rotator cuff repair in one ... an outside thread diameter of 5 mm and ... FiberWire suspension sutures securely hold a thin, bioabsorbable ...
... The Bio-SutureTak is a 3 mm bioabsorbable ... ideal for soft tissue attachment to bone in ... small anchor profile with high pull-out strength is ... molded into the body of the anchor and ...
TigerStick is a white #2 FiberStick with black stripes and a stiffened, 12 inch, waxed end. It is especially useful when motion determination and alternating colored sutures are required in the arthr...
... MMS soon offers the Flowmaster. It is ... everyday flow studies, where ease of use, simplicity ... wireless uroflowmeter which makes it now very easy ... the flowmaster anywhere you want and data will ...
Medicine Products: