Navigation Links
New recommendations issued for use of cetuximab in colon cancer therapy
Date:7/16/2010

Chapel Hill, NC In a report published in the July 2010 issue of the American Society for Clinical Oncology Post, new recommendations on the use of the drug cetuximab have been issued after officials halted enrollment in a phase III clinical trial in patients with spread of colon cancer into regional lymph nodes whose tumors had been surgically removed.

Based on earlier studies, cetuximab is now indicated for treatment of patients with advanced colorectal cancer whose tumors do not have a mutation in the KRAS gene. KRAS is one of a series of genes along a pathway that can lead tumors cells to grow, divide and evade signals that shut the cells down causing their death. Based on the results in advanced disease, researchers had hoped to see similar benefits when cetuximab was added to a standard chemotherapy regimen in earlier stages of colon cancer. However, ongoing analysis during the clinical trial found that patients receiving the combination therapy had no significant improvement in survival compared to standard therapy.

Cetuximab is a monoclonal antibody that inhibits epidermal growth factor receptor (EGFR) a cell signaling pathway that contributes to tumor growth. The drug is given by intravenous infusion for treatment of metastatic colorectal cancer and head and neck cancer. Previously, researchers found that patients with a mutated KRAS gene about 40 percent of those with metastatic colon cancer do not respond to the EGFR inhibitors currently in use.

However, the genetic test for KRAS mutation was not standard until this trial was well underway. Patients enrolled before KRAS testing were segmented from those in the rest of the study and analyzed separately, said Richard Goldberg, MD, chief of the division of hematology/oncology at the UNC-Chapel Hill School of Medicine, who presented the results for this group of patients.

"We expected that patients with the genetic mutation would not respond to cetuximab,
'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. AGA offers new recommendations for CRC surveillance for certain patients with IBD
2. ACR, SBI: Avon Survey Reveals Potentially Deadly Effects of USPSTF Mammography Recommendations
3. Critical Recommendations Unveiled to Respond to National Public Health Crisis: Deep-Vein Thrombosis and Pulmonary Embolism
4. Critical recommendations unveiled: Deep-vein thrombosis and pulmonary embolism
5. Critical Recommendations Unveiled to Respond to National Public Health Crisis: Deep-Vein Thrombosis and Pulmonary Embolism
6. SIUE Pain Summit Recommendations Announced Today
7. G8 to receive recommendations on women and childrens health
8. ACR task force makes recommendations for improving relationships between radiologists and hospitals
9. Aspirin recommendations changed for many younger diabetic patients
10. Study finds poor compliance with cirrhosis surveillance recommendations
11. New Guidelines Issued on Hormone Receptor Testing for Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/5/2015)... (PRWEB) , ... July 06, 2015 , ... ... ancillary benefits market, is excited to announce the next generation of PrimeStar Individual ... Advantage plans to now include two network options—Maximum Allowable Charge (MAC) and usual, ...
(Date:7/5/2015)... (PRWEB) , ... July 05, 2015 , ... Doctors at ... a new IMRT/surgery combination may one day change the outlook for people with pleural ... it now. , Researchers report that five mesothelioma patients treated with 25Gy ...
(Date:7/4/2015)... ... 2015 , ... Tyler Boden, Project Developer of Sullivan Solar ... the North American Board of Certified Energy Practitioners (NABCEP®), and is now a ... well established national certification organization for renewable energy professionals. Designation as a NABCEP ...
(Date:7/3/2015)... ... July 03, 2015 , ... Scientists at several top US cancer ... even minimal asbestos exposure. Click here to read the complete story , just ... Cancer Center, Cedars Sinai Medical Center, and New York University exposed mice with a ...
(Date:7/3/2015)... ... 2015 , ... Smoothies are all the rage right now and all you ... ingredients. Aurora Natural is proud to introduce a new line of all natural products ... vitamins and minerals! , Aurora is offering a variety of blends and stand-alone items ...
Breaking Medicine News(10 mins):Health News:Security Life Insurance Company of America Launches the Next Generation of PrimeStar Individual Dental Insurance Plans 2Health News:New Mesothelioma Study Calls IMRT/Surgery Combo “Innovative and Promising”, According to Surviving Mesothelioma 2Health News:Local Solar Professional Earns Industry's Most Prestigious Certification 2Health News:Local Solar Professional Earns Industry's Most Prestigious Certification 3Health News:Study Finds Small Amounts of Asbestos May Trigger Mesothelioma in People with Genetic Mutation, According to Surviving Mesothelioma 2Health News:Aurora Product, Inc. Announces An Original New Line: Smoothie Fixins’ 2
... HairConfirm, a new home ... Bartell Drugs , ... 11, 2009 -- HairConfirm, a new home drug hair test kit designed to help parents combat ... up to 90 days by analyzing small hair samples, providing a highly accurate and tamper-proof alternative ...
... ... and desktop-based telehealth capabilities anywhere, anytime , ... North Chelmsford, MA (PRWEB) June 11, 2009 ... communications solutions, and AMD Global Telemedicine Inc.(AMD) today announced an integrated voice and ...
... ... June), Dr Jav Nazemi - CEO of Igennus, manufacturer of purified omega-3 fish ... of his business and the omega-3 EPA formula, Vegepa, which has since helped ... week to the Children,s Heart Federation, in order to help support the lives ...
... ... , ... (PRWEB) June 11, 2009 -- Spectrum Surgical Instruments is a leading provider of surgical ... and each repair is backed by our 100% Satisfaction Guarantee. Spectrum,s new state-of-the-art National ...
... ... struggle for women of all ages. Despite the turmoil of unbalance being ... relief of menstrual and menopausal woes. Garden of Life, Inc., ( www.gardenoflife.com ... all ages a natural way to balance hormones with the launch of ...
... Laurence Barsh, DMD ... June 5, 2009 on the subject of educating the public about dentistry,s role in the management ... New ... of Dental Sleep Medicine in Seattle on June 5, 2009 on the subject of educating the ...
Cached Medicine News:Health News:New Home Drug Hair Test Kit Now Available from Bartell Drugs; ,HairConfirm Detects 90-Day Drug Use & Usage Frequency 2Health News:Polycom and AMD Global Telemedicine Inc. To Deliver Integrated Visual And Voice Telehealth Capability To Clinicians On-The-Go 2Health News:Polycom and AMD Global Telemedicine Inc. To Deliver Integrated Visual And Voice Telehealth Capability To Clinicians On-The-Go 3Health News:Omega-3 EPA: Treatment for a Heart Condition 2Health News:Omega-3 EPA: Treatment for a Heart Condition 3Health News:Omega-3 EPA: Treatment for a Heart Condition 4Health News:Omega-3 EPA: Treatment for a Heart Condition 5Health News:Omega-3 EPA: Treatment for a Heart Condition 6Health News:Three-Year Agreement for Surgical Instrument Repair Services 2Health News:MORE WOMEN SHUN HORMONE REPLACEMENT THERAPY Garden of Life Offers a Natural Solution with Oceans 3™ Healthy Hormones™ 2Health News:MORE WOMEN SHUN HORMONE REPLACEMENT THERAPY Garden of Life Offers a Natural Solution with Oceans 3™ Healthy Hormones™ 3Health News:MORE WOMEN SHUN HORMONE REPLACEMENT THERAPY Garden of Life Offers a Natural Solution with Oceans 3™ Healthy Hormones™ 4Health News:Founder of Snoring Isn't Sexy, LLC Addresses Annual Meeting of the American Academy of Dental Sleep Medicine 2
(Date:7/4/2015)... July 4, 2015 Adding ... patients with unresectable metastatic colorectal cancer in the ... organ Patients with unresectable metastatic colorectal ... liver experienced the greatest improvement in Progression-Free Survival ... SIR-Spheres Y-90 resin microspheres to a current first-line ...
(Date:7/3/2015)... -- According to a new market ... Market ECG, Implantable Loop Recorder, Manual Event Monitor, ... Chamber Pacemaker, CRT-D, CRT-P - Global Forecast to ... (CM) and Cardiac Rhythm Management (CRM) Devices Market ... from $21,137.7 Million in 2015, at a CAGR ...
(Date:7/3/2015)... July 3, 2015 ... vorbehaltlich bestimmter Abschlussbedingungen eine 100-prozentige Beteiligung am ... haben. Mit dieser Übernahme dringt Lupin in ... Umsatz von 765 Mrd. RUB im Jahr ... Welt gehörte (IMS Health). Seit über einem ...
Breaking Medicine Technology:New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 2New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 3New SIRFLOX Study Data Presented at World Congress of Gastrointestinal Cancer 4Cardiac Monitoring (CM) and Cardiac Rhythm Management (CRM) Devices Market Worth $26,646.5 Million by 2020 2Cardiac Monitoring (CM) and Cardiac Rhythm Management (CRM) Devices Market Worth $26,646.5 Million by 2020 3Cardiac Monitoring (CM) and Cardiac Rhythm Management (CRM) Devices Market Worth $26,646.5 Million by 2020 4Lupin übernimmt Biocom aus Russland 2Lupin übernimmt Biocom aus Russland 3
... BRUNSWICK, N.J., Dec. 15, 2010 Johnson & Johnson ... Gorsky, currently Worldwide Chairman, Medical Devices & Diagnostics (MD&D) ... appointed Vice Chairmen of the Executive Committee and join ... Executive Officer, in an expanded Office of the Chairman. ...
... Control Risks , one of the world,s leading ... its annual review and forecast of business risk for the ... and security risk in 173 countries. 2011 will ... both politically and economically, as the world,s emerging economies use ...
Cached Medicine Technology:Johnson & Johnson Announces Executive Appointments: Alex Gorsky, Vice Chairman, Executive Committee Sheri McCoy, Vice Chairman, Executive Committee 2Johnson & Johnson Announces Executive Appointments: Alex Gorsky, Vice Chairman, Executive Committee Sheri McCoy, Vice Chairman, Executive Committee 3Control Risks Forecasts New Reality for Business in 2011 Brought by Emerging Markets, Legislation 2
... patent pending solution using Radio Frequency ... smart label to promote patient safety ... wrong-procedure surgery. This simple to use ... surgeon with the operating room staff ...
... provide healthcare professionals witha patient'sname and ... speak, cant remember, oris unconscious. VeriMed ... individuals. The application can help these ... comparable level of care by rapidly ...
Computer-generated Smart CompuBand can be simultaneously printed with bar code information and programmed with RFID information...
... The HALO Infant Protection System helps ... equipment to ensure the operating efficiencies, cost ... even in todays busy and constrained healthcare ... getting the most reliable and versatile solution, ...
Medicine Products: