Navigation Links
New pyrimidine compounds may lead to improved treatments for childhood brain cancer
Date:4/6/2010

April 6, 2010 (Philadelphia, PA) -- Src (short for sarcoma) is a family of proto-oncogenic tyrosine kinases active in many cancer tumors, including medulloblastoma, the most common malignant cancer in children. Src represents one of the most promising targets for cancer therapy.

A recent study shows that pyrazolo-[3,4-d]pyrimidine-derivatives, designed to target Src, may be effective in interfering with the cell cycle and causing cancer cell death in medulloblastoma. The results were published in FASEB (The Journal of the Federation of American Societies for Experimental Biology) and were funded by the Sbarro Health Research Organization Center for Biotechnology (www.shro.org), a nonprofit group devoted to molecular and genetic research located at the College of Science and Technology at Temple University in Philadelphia, PA and the Human Health Foundation (www.hhfonlus.org), a nonprofit biotechnology research organization located in Terni, Italy.

"Our aim was to investigate the inhibitory effects of new pyrimidine-derivatives," said lead author Antonio Giordano, M.D. PhD, the Founder and Director of the Sbarro Institute for Cancer Research and Molecular Medicine and a 'Chiara fama' Professor at the Department of Human Pathology and Oncology, University of Siena, Siena, Italy. "Our findings show that, in medulloblastoma cells, pyrimidine derivatives can downregulate Src activity and reduce cell proliferation and tumor progression in vivo. This suggests that pyrimidine derivatives could be an effective therapeutic strategy not only for the treatment of medulloblastomas, but also for other Src expressing tumors."

Although better treatment regimens, including surgery, chemotherapy and radiotherapy have substantially improved survival, medulloblastoma remains incurable in about one third of patients and current treatments can cause toxic neurocognitive side effects.

"Compared
'/>"/>

Contact: Ilene Rush
irush@shro.org
215-470-2998
Sbarro Health Research Organization
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Sigma-Aldrich Reaches Agreement to Sell Pfizers Bioactive Small Molecule Compounds
2. Compounds Identified That Might Treat Nerve Diseases
3. Prenatal exposure to flame-retardant compounds affects neurodevelopment of young children
4. Marijuana Compounds Could Beat Back Brain Cancer
5. Spice Compounds May Stem Tumor Growth
6. Foster care associated with improved growth, intelligence compared to orphanage care
7. Improved device provides more rapid, comprehensive analysis of circulating tumor cells
8. Improved patient care with telemonitoring
9. Improved doctor-pharmacist collaboration needed: study
10. An improved method for calculating tumor growth
11. TeraMedica Unveils Improved Univision, Now Offering a Multi-Layer Enterprise Viewing Platform
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... research co-funded by the Engineering and Physical Sciences ... of the UK,s vital industrial control systems which ... electricity grid, and the rail network. , ... from hackers or malware infiltrating the systems behind ... Institute in Trustworthy Industrial Control Systems (RITICS), based ...
(Date:10/1/2014)... 01, 2014 Marriagelifeinsurance.com has released ... insurance for retired couples. , Senior citizens can ... security for their loved ones. A joint policy is ... persons pass away. , Life insurance can be ... insurance can even be purchased online, as the application ...
(Date:10/1/2014)... Phoseon Technology, the pioneer in developing ... business worldwide. This rapid growth includes increased hiring for ... efforts. The company has experienced average annual growth rates ... this growth to continue in the future as new ... , “We are very pleased that UV ...
(Date:10/1/2014)... 01, 2014 Beverly Hills licensed Clinical ... is celebrating 20 years of private practice in her ... people to achieve greater joy and fulfillment in their ... warning signs and suggestions for anyone who suspects they ... “Believe it or not, it’s not always easy ...
(Date:10/1/2014)... Anti Aging Clinic (AntiAgingClinic.ca), the Greater ... of choice, is announcing a discounted cost on Botox ... , “We’re doing this because we want to give ... skin clinic in Toronto,” says Dr. Brian Sieber, founder ... Anti Aging Clinic, including laser facials, genesis laser facials, ...
Breaking Medicine News(10 mins):Health News:£2.5 million to recognize and reduce cyber-attack threats to critical infrastructure 2Health News:Elderly Life Insurance - Find Life Insurance for Retired Couples! 2Health News:Phoseon Technology Continues to Drive Growth Worldwide 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 3Health News:Anti Aging Clinic, the GTA’s Premier Provider of Anti Aging Treatments, Announces Deal on Units of Botox 2
... June 13 (Pink Sheets: ICTY) As of,June 11, ... that is,going to completely revamp the company and move ... very tight and secure team of corporate,individuals are in ... must be addressed prior to the release of any ...
... HILL, N.C., June 13 Market competition ... interest of the most highly,qualified clinical investigators. ... clinical investigators to their studies win an ... Best Practices, LLC,s white paper "Recruiting and ...
... could detect disease sooner, when it,s more treatable , , FRIDAY, ... development of pancreatic cancer have been identified by U.S. researchers, ... to develop a blood test to detect this type of ... , "Our team identified, for the first time, protein ...
... Paris, France, Friday 13 June 2008: Rheumatoid ... (PsA) patients should undergo compulsory cardiovascular (CV) risk ... adapted to the increased CV risk in inflammatory ... ,Cardiovascular Risk Management in RA, recommended today at ...
... End of Life Urges Congress to Preserve ... Compassionate End-of-Life Care, WASHINGTON, June ... Payment Advisory Commission (MedPAC),reported that the rapid growth of the Medicare ... and more spending per,beneficiary. According to the report, "Evaluating Medicare,s Hospice,Benefit," ...
... 13 June 2008: A new DNA microarray chip can ... arthritis (RA), as presented today at EULAR 2008, the ... Paris, France. The chip (called the ,ARTchip,) has yielded ... in anticipating likely disease progression and prognosis and thereby ...
Cached Medicine News:Health News:EyeCity.com, Inc. Changes Ownership and Moves Into a New Direction 2Health News:Pancreatic Cancer Biomarkers Found 2Health News:CV risk management should be mandatory in RA and other types of inflammatory rheumatic disease 2Health News:CV risk management should be mandatory in RA and other types of inflammatory rheumatic disease 3Health News:More Data Needed Before Changing Medicare Hospice Funding, Report Finds 2Health News:More Data Needed Before Changing Medicare Hospice Funding, Report Finds 3Health News:Novel DNA microarray chip predicts functional impairment and remission in rheumatoid arthritis 2
(Date:9/30/2014)... Sept. 30, 2014 /CNW/ - Protecting the health and safety of ... Canada uses the appropriate powers and tools at its disposal to ... and quality standards. To that end, Health ... the import into Canada of all drug ... They are: , Apotex Pharmachem India Pvt Ltd ...
(Date:9/30/2014)... , Sept. 30, 2014  Hologic, Inc. (NASDAQ: ... , Hologic,s President and Chief Executive Officer, will preside ... October 1, the first day of Breast Cancer Awareness ... Company,s campaign focused on the important benefits of Hologic,s ... the FDA as clinically superior to traditional mammography. ...
(Date:9/30/2014)... -- This study provides an analysis of the ... nuclear imaging informatics, PET imaging informatics, and multimodality ... size of the market based on its historic ... growth based on the current drivers and restraints, ... the broader markets for imaging equipment, advanced visualization, ...
Breaking Medicine Technology:Statement by the Honourable Rona Ambrose on the import ban of drug products from three plants in India 2Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 2Hologic to Kick Off National Breast Cancer Awareness Month at the October 1 NASDAQ Stock Market Opening Bell Ceremony 3Analysis of the US Molecular Imaging Informatics Market 2Analysis of the US Molecular Imaging Informatics Market 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: