Navigation Links
New protein discovery helps researchers understand autoimmune diseases
Date:3/6/2008

APS-1 is an rare hereditary disease where the immune system attacks the bodys own organs. Within the framework of a major EU project, coordinated by Professor Olle Kmpe at Uppsala university, scientists have now managed to identify a protein that opens new possibilities of understanding both APS-1 and other autoimmune disorders. The discovery is being published in the American journal The New England Journal of Medicine.

The newly discovered protein, which goes by the name of NALP5, constitutes the target for the immune systems attacks on the parathyroid glands in the disease APS-1. This finding enables researchers to more closely study the first phase of autoimmune disorders in general, where immune cells, instead of attacking alien bacteria and viruses, erroneously attack the bodys own tissue.

The protein functions as a target for the immune cells in humans, but also in animal models for the disease that have the same genetic defect as APS-1 patients.

This means now, for the first time, in an experimental situation we will be able to compare the immune defense with exactly the same target protein in humans and in an animal model, says Mohammad AliMohammadi at the Department of Medical Sciences, Uppsala University, who made the discovery.

The parathyroid glands are the most recently described anatomical structures in humans. They were discovered in 1879 by scientists at Uppsala University and regulate the bodys calcium balance. The fact that the protein NALP5 was found in the parathyroid glands enhances our understanding of their functions. In the long run this discovery can make it possible to develop drugs and treatment methods for diseases producing disturbances in the calcium balance, such as osteoporosis.

In patients with APS-1 the parathyroid glands can be knocked out at a very young age, which can lead to severe cramp attacks that regular cramp treatment is powerless to alleviate. If the disease is not discovered, it therefore often leads to death. The new discovery also makes it possible to diagnose the disease early, so that patients can receive the appropriate treatment.


'/>"/>

Contact: Mohammad AliMohammadi
Mohammad.Alimohammadi@medsci.uu.se
46-070-882-9922
Uppsala University
Source:Eurekalert

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... 18, 2017 , ... President Donald Trump signed into law ... for greater public access to over-the-counter (OTC) hearing aids. , The measure enables ... without being seen by a certified and licensed audiologist. , “The American ...
(Date:8/19/2017)... ... 19, 2017 , ... Praeclarus Press has launched a ... the diversity of the breastfeeding mothers, using bright colors and contemporary themes. ... illustrations are also available on tote bags, notepads, smartphone cases, clocks, and travel ...
(Date:8/19/2017)... ... August 19, 2017 , ... Physician Partners of America Pain ... an interventional pain management physician. He brings a wealth of pain management experience ... and significant experience in spinal cord stimulation for chronic pain. , Dr. Ahmed ...
(Date:8/18/2017)... Lynchburg, VA (PRWEB) , ... August 18, 2017 , ... ... to the Democratic Republic of Congo (DRC) thanks to an ambitious venture that conjoined ... as well as the generous support of the Liberty community. These shoes will save ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... campaign, advocating for active, healthy lifestyles and highlighting the importance of proactive eye ... hearing impairments and shares the latest innovations in hearing aid technology. , ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)...   Mostyn Law and Gulf Coast Regional Blood Center ... . The Mostyn Law family has had 3 members ... why Mostyn Law is partnering with Gulf Coast Regional ... appreciation. Blood supplies are running low. Gulf Coast Regional ... needs in August. That is why the blood center reached out ...
(Date:8/14/2017)... and PETACH TIKVAH, Israel , ... BCLI), a leading developer of adult stem cell technologies ... quarter ending June 30, 2017. ... preparing for our pivotal Phase 3 trial to investigate ... , President and Chief Executive Officer of BrainStorm. "We ...
(Date:8/7/2017)... , Aug. 7, 2017 Insightin ... member acquisition, retention, and engagement, announced the selection ... Strategy and Product Development, effective as of February 2017. ... and technology implementation strategy for our clients. Wood ... experience in consulting and business analytics within the ...
Breaking Medicine Technology: