Navigation Links
New protein discovery helps researchers understand autoimmune diseases
Date:3/6/2008

APS-1 is an rare hereditary disease where the immune system attacks the bodys own organs. Within the framework of a major EU project, coordinated by Professor Olle Kmpe at Uppsala university, scientists have now managed to identify a protein that opens new possibilities of understanding both APS-1 and other autoimmune disorders. The discovery is being published in the American journal The New England Journal of Medicine.

The newly discovered protein, which goes by the name of NALP5, constitutes the target for the immune systems attacks on the parathyroid glands in the disease APS-1. This finding enables researchers to more closely study the first phase of autoimmune disorders in general, where immune cells, instead of attacking alien bacteria and viruses, erroneously attack the bodys own tissue.

The protein functions as a target for the immune cells in humans, but also in animal models for the disease that have the same genetic defect as APS-1 patients.

This means now, for the first time, in an experimental situation we will be able to compare the immune defense with exactly the same target protein in humans and in an animal model, says Mohammad AliMohammadi at the Department of Medical Sciences, Uppsala University, who made the discovery.

The parathyroid glands are the most recently described anatomical structures in humans. They were discovered in 1879 by scientists at Uppsala University and regulate the bodys calcium balance. The fact that the protein NALP5 was found in the parathyroid glands enhances our understanding of their functions. In the long run this discovery can make it possible to develop drugs and treatment methods for diseases producing disturbances in the calcium balance, such as osteoporosis.

In patients with APS-1 the parathyroid glands can be knocked out at a very young age, which can lead to severe cramp attacks that regular cramp treatment is powerless to alleviate. If the disease is not disc
'/>"/>

Contact: Mohammad AliMohammadi
Mohammad.Alimohammadi@medsci.uu.se
46-070-882-9922
Uppsala University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... Carolinas Healthcare System celebrated today the grand ... System - Anson located in Anson County. The $20 ... in Wadesboro. , Located on U.S. Highway 74, the ... facility. Situated on a 10-acre site, the new hospital ... drop-off, helipad, healing garden, and 15 beds. With fewer ...
(Date:7/13/2014)... identifies a novel genetic and molecular pathway in ... up potential new therapeutic strategies for an enigmatic ... a chronic inflammatory disorder of the esophagus. The ... foods and an over-accumulation in the esophagus of ... body,s immune system). EoE can cause a variety ...
(Date:7/13/2014)... Chromatography system is a physical ... types of biological samples such as air and ... into two phase, namely mobile phase and stationary ... over the stationary phase, followed by the differential ... the separation of mixture. Chromatography system plays an ...
(Date:7/13/2014)... Victorian Hotel has recently announced that it ... bikes for its "Cycle the City" program, which encourages ... the area using a rental bicycle, available for just ... call Vancouver home, as it is a city with ... journeys through the countryside. Vancouver hotel rooms often play ...
(Date:7/13/2014)... July 13, 2014 Micro irrigation systems ... proper water dispersal as wells as to maintain soil ... is projected to become a dominant revenue generator for ... methods to reduce resource costs has led to the ... plantations, and has further caused massive demand for micro ...
Breaking Medicine News(10 mins):Health News:Carolinas HealthCare System - Anson Hospital Now Open 2Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 2Health News:Study finds cause of mysterious food allergy, suggests new treatment strategy 3Health News:North America Chromatography Systems Market Is Expected to Reach $6593.4 Million by 2018 - New Report by MicroMarket Monitor 2Health News:North America Chromatography Systems Market Is Expected to Reach $6593.4 Million by 2018 - New Report by MicroMarket Monitor 3Health News:Victorian Hotel Creates Excitement by Adding "Cycle the City" Bike Rentals for Its Vancouver Hotel Rooms 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 2Health News:Agricultural Micro Irrigation System Market is Expected to Grow at a CAGR of 18.1%, from 2013 to 2018 - New Report by MicroMarket Monitor 3
... signs aren,t just for newlyweds anymore. , They are also ... sexual expression, according to Kansas State University aging experts. , ... can offer residents some privacy," said Gayle Doll, who directs ... a problem for nursing home residents who want to engage ...
... Between the ages of six months and six years old, ... sleep-related problem. Among the most common issues are night terrors, ... a stage that passes. But at least 30 percent of ... hours either because they can,t fall into slumber or ...
... women to move directly from work to retirement, but ... complex and call for additional considerations in planning for ... Mandel School of Applied Social Sciences at Case Western ... reality that retirement is a straight path from working ...
... A study of patients, at the Christie Hospital, Manchester, ... depends more on where the patient lives, than the ... lottery" since each decision is made solely by the ... this study are published in a letter to ...
... Conducted by TechWeb, Survey Reveals 50% of End Users Have Altered ... ... Scottsdale, AZ (PRWEB) November 18, 2008 -- Securing business-technology systems ... and TechWeb Research "State of Data Protection" survey . ...
... in one of the external groups of the Instituto Gulbenkian ... which regulates the process whereby new blood vessels are formed ... in diabetic patients and those suffering from morbid obesity. These ... in the new issue of the journal PLoS ONE ...
Cached Medicine News:Health News:K-State helps nursing home staff become comfortable with residents' sexual expression 2Health News:26 percent of sleepless children become overweight 2Health News:Case Western Reserve University study examines working couple's retirement patterns 2Health News:A postcode lottery still exists for cancer patients with 'exceptional circumstances' 2Health News:Lumension Uncovers Results of Security Data Protection Survey 2Health News:Lumension Uncovers Results of Security Data Protection Survey 3Health News:Portuguese scientists discover new mechanism that regulates formation of blood vessels 2
(Date:7/10/2014)... MUMBAI, India , July 11, 2014 /PRNewswire/ ... the treatment of cancer are being highlighted in ... Mumbai from 10-12 July, 2014.  Renowned ... meeting to share best practices and exchange knowledge ... more precise, accurate and efficient. ...
(Date:7/10/2014)... , July 10, 2014  The U.S. Department ... three-year grant to University Hospitals (UH) Case Medical Center ... new national model aimed at improving care for patients ... Care," the project will test a unique model developed ... with late-stage disease, significant comorbidities, or demonstrated need for ...
(Date:7/10/2014)... 10, 2014 Integrated Silicon Solution, Inc. (Nasdaq: ... and analog IC solutions, today announced that it will ... 2014, at 7:00 a.m. Pacific Time (10:00 a.m. Eastern ... fiscal 2014 third quarter ended June 30, 2014. ... 1-888-556-4997 before 6:50 a.m. Pacific time on July 24, ...
Breaking Medicine Technology:Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4
... Finntip Filters are ideal ... methods, or for any work ... They are designed for pipetting ... samples, and other. For applications ...
Inquire...
... Filters are ideal for PCR ... for any work where aerosol ... designed for pipetting DNA/RNA solutions, ... other. For applications requiring absolute ...
... Eliminate aerosol contamination, ... reactions in PCR. Hydrophobic, ... Only air can pass ... tips, in contrast to ...
Medicine Products: