Navigation Links
New promising therapy against systemic sclerosis
Date:6/14/2010

There is a new path to defeat systemic sclerosis, also called scleroderma because of the hardening of the skin of the patients (from Greek skleros, "hard", and derma, "skin"). This path involves the B-cell of the immune system, so far only considered "innocent spectators," as Catholic University rheumatologist Gianfranco Ferraccioli, among the authors of the important research, puts it. Also Silvia Bosello, Maria De Santis, Gina Lama, Cristina Span, Cristiana Angelucci, Barbara Tolusso e Gigliola Sica, director of the Institute of Histology and Embryology, all working for the Catholic University of Rome, have all actively taken part in this research, published on the last issue of Arthritis Therapy & Research.

"What makes our work truly original," says Ferraccioli, "is that it clarifies the characteristics of a disease, very complex as all autoimmune diseases, whose patients have often no possibility other than having to undergo a long immunosuppressive cytotoxic therapy or a medullary transplant. Furthermore, this pathology often involves more organs and is doomed to high chance of failure with conventional therapies".

Scleroderma is characterized by a fibrosis a thickening of tissues due to the accumulation of matrix proteins that are not re-absorbed. By progressively hardening tissues and making them less elastic, these proteins alter the function of the organs. If, for example, the lung is involved, oxygen exchanges in the alveoli become more difficult. If the heart is involved, it gets harder and pumps blood inefficiently. If the intestinal tract is involved, it is more difficult to void it. A very common effect is the thickening and hardening of the skin, which takes on a leather-like aspect.

"There are two different forms of this disease," explains Ferraccioli. "The first, and more frequent one, involves 80% of patients. This form is called limited, and has a slower and less aggressive progression. The second type, c
'/>"/>

Contact: Gianfranco Ferraccioli
gf.ferraccioli@rm.unicatt.it
0039-347-322-4547
Catholic University of Rome
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Promising new neuroimaging techniques for early detection of Alzheimers disease
2. LSUHSC research yields promising stroke treatment
3. New insights into mushroom-derived drug promising for cancer treatment
4. UV LED therapy shows promising results in preventing focal seizures
5. Promising New Results On The Added Safety Of Using SmokeStik Electronic Cigarettes In The Bid To Quit Smoking
6. Carfilzomib Safety Data From Ongoing Phase 2b Pivotal Trial in Relapsed and Refractory Multiple Myeloma Show Promising Safety and Tolerability
7. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Promising therapy for relapsing multibple sclerosis
10. New strategy produces promising advance in cancer vaccines
11. Sytropin HGH Shows Promising Anti-Aging Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Steven Reinberg HealthDay Reporter , , THURSDAY, May ... heartburn may be at increased risk for cancers of ... smoke or drink alcohol, a new study says. ... cancers while prescription medications such as Prilosec, Nexium and ... a controversy about whether heartburn contributes to cancers of ...
(Date:5/23/2013)... of older adults with dementia are less stressed ... dementia patients receive adult day services (ADS), according ... with and care for someone with dementia can ... professor and head, human development and family studies. ... provide caregivers with a much-needed break that can ...
(Date:5/23/2013)... YORK (May 23, 2013) -- Little is known about ... why response to treatments varies between patients. Now, a ... University Medical Center and SUNY Downstate Medical Center has ... asthma, showing that it is very different from other ... Medicine , reveals that an over-active gene linked in ...
(Date:5/23/2013)... researchers at Henry Ford Hospital found "substantial evidence" that ... spinal cord could hold the key to better functional ... new hope to those who suffer stroke, the leading ... victims recover some ability to voluntarily use their hands ... weakness on one side of their bodies, while a ...
(Date:5/23/2013)... It is Go Classy Tours / Caribbean Hideaways' ... Spa , a luxury nudist resort located in the Rivera ... International Naked Painting Party. Hidden Beach is a perfect location ... Hot Tub, Nude Bars & Nightclub and Nude Dinning. ... August 15th and go through August 18th, with the actual ...
Breaking Medicine News(10 mins):Health News:Chronic Heartburn May Raise Odds for Throat Cancer: Study 2Health News:Adult day services for dementia patients provide stress relief to family caregivers 2Health News:Researchers find common childhood asthma unconnected to allergens or inflammation 2Health News:Researchers find common childhood asthma unconnected to allergens or inflammation 3Health News:Regenerating spinal cord fibers may be treatment for stroke-related disabilities 2Health News:Regenerating spinal cord fibers may be treatment for stroke-related disabilities 3Health News:Hidden Beach, the Only Luxurious All-inclusive Nudist Resort in the Mexican Caribbean, to Host Social Exposure's Naked Painting Party, Announces Go Classy Tours 2
... INDIANAPOLIS, June 22 The board of directors of Eli Lilly and ... third quarter of 2009 of $0.49 a share on outstanding common stock. ... and second quarters and maintains the annual indicated dividend rate for 2009 ... September 10, 2009, to shareholders of record at the close of business ...
... blames physician misdiagnosis as the likely cause of apparent uptick ... A newly released study in the June 2009 British Journal ... the eastern United Kingdom has concluded that the much-hyped melanoma ... The study attributed the increase in melanoma diagnoses to heightened ...
... MIAMI, June 22 Now there,s a new ... time, suggests a new,study published in the July issue of ... drinking fat free milk in the,morning helped increase satiety, or ... the next meal, as compared with a fruit drink. The,milk ...
... , , , Personalized Medicine Meeting ... The Food and Drug Administration,s (FDA,s) ability to regulate genetic ... medicine stakeholders. , , Three-quarters of the attendees ... and Drug Law Institute (FDLI) and the American Association for ...
... NIH declines to attend field hearing exploring use of Recovery ... U.S. Senator Benjamin L. Cardin (D-MD ), chaired a ... Business and Entrepreneurship in Rockville, MD, entitled " Missed ... the hearing, local and national experts in biotechnology testified about ...
... Courage Center,s two camps, Camp Courage in Maple Lake ... camp schedule for people with disabilities. , , A recent ... participants (campers and MDA staff) who tested positive for H1N1 flu ... 6-12. Courage Center officials were contacted by the MDA locally three ...
Cached Medicine News:Health News:New Study Says Purported Melanoma Epidemic is Vastly Overstated 2Health News:Drinking Milk in the Morning May Help Stave off Lunchtime Hunger 2Health News:FDA's Current Ability to Regulate Genetic Testing is Problematic, FDLI-AAAS Colloquium Attendees Say 2Health News:FDA's Current Ability to Regulate Genetic Testing is Problematic, FDLI-AAAS Colloquium Attendees Say 3Health News:Cardin Calls on NIH to Utilize Small Businesses for Extramural Research Projects 2Health News:Courage Camps Maintain Summer Camp Schedule for Children and Adults With Disabilities 2
(Date:5/23/2013)... , May 23, 2013  Intercept Pharmaceuticals, Inc. (Nasdaq: ... company focused on the development and commercialization of novel ... as primary biliary cirrhosis, today announced that ... Officer, will present at the Deutsche Bank Securities 38th ... on Wednesday, May 29, 2013 at 4:10 p.m. ...
(Date:5/23/2013)... , May 23, 2013  Omeros Corporation (NASDAQ: ... Investigational New Drug Application (IND) to evaluate OMS824 ... U.S. Food and Drug Administration (FDA). OMS824 selectively ... areas of the brain linked to a wide ... disease and schizophrenia. OMS824 has shown promising results ...
(Date:5/23/2013)...  MedVantx, Inc., the company that has pioneered a ... the Company has completed a major expansion of its ... and the upgrade of its systems to offer a ... specialty home delivery pharmacy in Sioux Falls, ... physicians, health systems and payors novel distribution services, as ...
Breaking Medicine Technology:Investigational New Drug Application Cleared by FDA for OMS824 in Huntington's Disease 2Investigational New Drug Application Cleared by FDA for OMS824 in Huntington's Disease 3Investigational New Drug Application Cleared by FDA for OMS824 in Huntington's Disease 4MedVantx Achieves Significant Milestone of Managing $1.5B in Prescription Medications and Completes Facilities Expansion While Upgrading To Offer Current Good Manufacturer Practices (cGMP)-level Quality Systems in their Home Delivery Pharmacy 2MedVantx Achieves Significant Milestone of Managing $1.5B in Prescription Medications and Completes Facilities Expansion While Upgrading To Offer Current Good Manufacturer Practices (cGMP)-level Quality Systems in their Home Delivery Pharmacy 3
...  Today at the 21st Annual National Mobility Equipment Dealers ... Awareness Month was unveiled, which will be celebrated throughout ... of the awareness month is to teach seniors, veterans ... and mobile lifestyle through the use of wheelchair accessible ...
... 60 Plus Association today sent a letter of gratitude ... contacted the Federal Trade Commission (FTC) with concerns over ... Scripts, Inc. and Medco Health Solutions. The organization made ... of their 7.1 million supporters to defend patient choice, ...
Cached Medicine Technology:NMEDA Introduces National Mobility Awareness Month for Seniors, Veterans and People with Disabilities 260 Plus Association Applauds Opposition to PBM Merger 2
15" Monopolar Electrode, Ins., Hook Tip...
... versatile, dependable 990 frame the ... and completes the Nova diagnostic ... stands out due to its ... and its integral safety cut ...
... is an innovative and efficient inverted ... complements any research facility. Improved mechanics ... offers the TS100 binocular and TS100-F ... comes with a photo port that ...
... monochrome IR/DIC video camera. Olympus wide array of ... image quality and flexibility you need for an ... high-resolution, real-time image of your specimen that can ... TV. You can even record movies when these ...
Medicine Products: