Navigation Links
New prognostic markers for gastric cancer patients

In standard clinical settings, DNA microarrays are currently unsuitable for routine use. Prognostic classification on formalin-fixed paraffin-embedded tissues is required. In this study, we looked for new molecular markers for identifying the prognosis of gastric cancer patients.

This study, performed by a team led by Professor Zhong-Sheng Zhao, is described in a research article to be published on April 7, 2008 in the World Journal of Gastroenterology.

The team identified that syndecan-1, E-cadherin and integrins highly correlated with each other as intracellular adhesion molecular complexes. We suggest the results of co-examination of them can be important indexes for the prognosis of gastric carcinoma. In the view of the authors, to date no clear mechanism has been found to explain the interaction of the three molecules, and no clinical research has been done to verify the findings.

Traditional clinicopathologic factors and several interesting molecules, including cell cycle regulation factors such as p27 or cyclin E, cell adhesion molecules such as E-cadherin, angiogenic factors such as vascular endothelial growth factor and placenta growth factor, oncogenes such as c-erbB2 and c-myc, and tumor suppressor genes such as p53, have been reported to correlate to the prognosis of gastric cancer patients. Cell adhesion is one of important steps in the multi-step process of gastric cancer pathogenesis.

Further research should collect more samples and emphasize the importance of studying multiple genetic alterations in concert.


Contact: Jing Zhu
World Journal of Gastroenterology

Page: 1

Related medicine news :

1. Body Mass Index may serve as prognostic tool for advanced, aggressive breast cancers
2. Genomic Health Announces Oncotype DX(R) Provides Additional Prognostic Benefit in Patients Assessed With Adjuvant Online
3. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
4. Biomarkers Predict Heart Deaths
5. New Thomson Reuters Biomarkers Report Shines a Light on Revolutionary New Area of Drug Development
6. Researchers important markers of high risk of type 2 diabetes
7. New Heart Disease Markers Discovered
8. Biomarkers may reduce need for biopsies
9. Scientists: New technique identifies molecular biomarkers for disease
10. Large multicenter study suggests new genetic markers for Crohns disease
11. Fewer Steps Per Day Send Disease Markers Up
Post Your Comments:
(Date:10/13/2017)... ... , ... Talented host, actor Rob Lowe, is introducing a ... episode of "Success Files," which is an award-winning educational program broadcasted on PBS ... in-depth with passion and integrity. , Sciatica occurs when the sciatic nerve in ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ), one ... an innovative new design of the shoulder pad. The shoulder pad provides optimal ... controlling your pain while using cold therapy. By utilizing ice and water that is ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Mohebi Hair Restoration, has recently contributed a medical article to the newly revamped ... Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... one of Michigan’s 2017 Best and Brightest in Wellness® by Best and Brightest. ... awards program on Friday, Oct. 20 from 7:30 a.m. to 2 p.m. at ...
Breaking Medicine News(10 mins):
(Date:9/23/2017)... -- Janssen Biotech, Inc. (Janssen) announced today that it ... Food and Drug Administration (FDA) for the Biologics License ... of moderately to severely active rheumatoid arthritis (RA). The ... to further evaluate the safety of sirukumab in the ... "We are disappointed by ...
(Date:9/22/2017)... 2017 AVACEN Medical (AVACEN) announced that its ... helping those with the widespread pain associated with fibromyalgia ... in Essex, England commented, "I ... experiencing no sleep at all, tremendous pain, with every ... recommend [the AVACEN 100] enough, how this has and ...
(Date:9/19/2017)... Sept. 19, 2017   ZirMed Inc ., a recognized ... announced that it has been ranked #1 by its users ... Rankings 2017 User Survey. ZirMed was recognized as the ... hospitals and medical centers over 200 beds and holds one ... technology user survey history. ...
Breaking Medicine Technology: