Navigation Links
New prion protein discovered by Canadian scientists may offer insight into mad cow disease
Date:8/16/2007

Scientists have discovered a new protein that may offer fresh insights into brain function in mad cow disease. Our team has defined a second prion protein called Shadoo, that exists in addition to the well-known prion protein called PrP said Professor David Westaway, director of the Centre for Prions and Protein Folding Diseases at the University of Alberta.

For decades we believed PrP was a unique nerve protein that folded into an abnormal shape and caused prion disease: end of story. This view is no longer accurate, Westaway adds.

The study was conducted jointly by the University of Toronto, University of Alberta, Case Western Reserve University (Ohio) and the McLaughlin Research Institute (Montana). The research is published today in the EMBO Journal and represents a culmination of work initiated at the University of Toronto in 1999, and then continued more recently at the University of Alberta.

This is the first discovery since 1985 of a new brain prion protein. A second prion protein had been inferred by other research, based on indirect studies and the examination of DNA sequences, said lead author Joel Watts, a graduate student at the University of Torontos Centre for Research in Neurodegenerative Diseases. But we not only demonstrate that this theoretical protein really exists and shares several properties with healthy PrP; we have also defined an unexpected alteration in prion infections.

As the PrP molecule alters shape and accumulates in a prion-affected brain, the Shadoo protein seems to disappear, Watts added. Since proteins in a living cell are the molecules that do the work, this is likely to be significant, he said.

Many facets of a prion disease like BSE are puzzling, Westaway said. The puzzles include the cause of death of brain cells, the function of normal prion proteins, and the rules governing emergence and spread of prions from animal to animal. We believe the Shadoo protein can give us a fr
'/>"/>

Contact: Bev Betkowski
beverly.betkowski@ualberta.ca
780-492-3808
University of Alberta
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Prion Disease Agent Causes Heart Damage
2. Single Protein Plays A Major Role In Prion Diseases
3. Role of Hsp 104 in the Spread of Prion Diseases
4. Study Finds Prion Proteins in Milk
5. Vaccine Prevents Prion Disease in Mice
6. Vaccine Prevents Prion Disease in Mice
7. Significant Advances in VCJD Prion Detection
8. Prions Capacity can Be Aggrevated by Solid Particles
9. New Insights into Prion Propogation
10. Prions Prevent Alzheimers Disease
11. Lean Protein Could Be Key to Obesity Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Friendship Village of Schaumburg is ... creates a contemporary marketing presence and visually solidifies ... organization, Friendship Senior Options,” said Stephen A. Yenchek, ... changing the logo, we are making sure that ... and their families.” , Friendship Village is a ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 Cloud Medical ... of “Cloud Based” Medical Practice Business Operations solutions and ... of Digital Cyber Security solutions for all industries announced ... on the trading floor of the CME in Chicago ... DeLaGarza stated that we are very proud of the ...
(Date:9/2/2014)... NY (PRWEB) September 02, 2014 The ... new blood thinners is growing at a rapid pace, ... to mount in courts around the U.S., Bernstein Liebhard ... American Journal of Medicine, within a year of its ... prescribed Xarelto as warfarin, a blood thinner that has ...
(Date:9/2/2014)... SC (PRWEB) September 02, 2014 The Wm. ... outreach fair and public town hall meeting for Veterans and ... available at the outreach fair to provide Veterans with valuable ... McMurry. “The town hall will provide a forum where we ... VA programs.” , The outreach fair will be held 4:45 ...
(Date:9/2/2014)... 02, 2014 On August 30, 2014, ... titled “Why You Should Wash Your Face .” ... the global population breathes air considered polluted by the ... lodge in the skin’s pores destroying its natural oils. ... free radicals that may cause cell damage, redness, ...
Breaking Medicine News(10 mins):Health News:Friendship Village of Schaumburg In Illinois Announces New Logo 2Health News:Cloud Medical Doctor Software Corporation's CEO Interviewed by the Price Futures Group 2Health News:Cloud Medical Doctor Software Corporation's CEO Interviewed by the Price Futures Group 3Health News:Xarelto Lawsuit News: Bernstein Liebhard LLP Comments on Growing Use of Xarelto in Spite of Mounting Product Liability Litigation 2Health News:Xarelto Lawsuit News: Bernstein Liebhard LLP Comments on Growing Use of Xarelto in Spite of Mounting Product Liability Litigation 3Health News:Xarelto Lawsuit News: Bernstein Liebhard LLP Comments on Growing Use of Xarelto in Spite of Mounting Product Liability Litigation 4Health News:Simon Ourian, Kim Kardashian’s Doctor: Air Pollution May Be Aging Your Skin 2
... common problem among women. However statistics show that among people ... with knee joint pain, obese people are in the majority. ... definite about the reasons for the knee pain. //Majority of ... briefly. ,The basic sturcture of knee joint is composed ...
... young as even 3 days old can tell whether someone ... author, doubts that humans have evolved to be sensitive to ... Farroni is a researcher with the Centre for Brain and ... University of London.// ,Farroni, felt that newborns are not ...
... The first major trans-Atlantic telesurgical operation has been carried ... from a patient in eastern France by remotely operating ... for a surgeon to perform an operation on a ... Institute of Telesurgery in Strasbourg say the procedure was ...
... their new study suggested that, along with calcium, protein ... Getting enough calcium is essential for building and maintaining ... men and women who were taking calcium citrate malate ... density increased most in people whose diets contained the ...
... a biomedical engineer at the University of Pittsburgh makes ... your eyes. The prototype device merges the visual outer ... scan of what lies beneath. It creates the effect ... 3D location with the patient, showing blood vessels, muscle ...
... with Alzheimer’s may worsen the symptoms of Parkinson’s ... could improve treatments for these conditions, say US ... up to one-third of Alzheimer’s patients develop Parkinson’s ... ,To research a possible link between ...
Cached Medicine News:Health News:New combined therapy for Knee Joint pain 2Health News:Newborns Know how to make eye contact 2Health News:Calcium and Protein Equals Strong Bones 2Health News:New form of ultrasonic vision 2
(Date:9/2/2014)... Sept. 2, 2014 The Pharmaceutical Care Management ... managers (PBMs), today filed a lawsuit in ... Iowa law that restricts tools ... the state,s employers and consumers.  The ... severely restricting the use of Maximum Allowable Cost (MAC) ...
(Date:9/2/2014)... CALGARY, Alberta , September 2, 2014 ... der "State of the Art and Featured Research Session" ... Resverlogix Corp. (TSX: RVX) gab heute bekannt, dass Dr. Jan ... beim Kongress des europäischen Kardiologenverbandes (ESC) 2014 in ... In seinem Vortrag mit dem Titel " Effects of ...
(Date:9/2/2014)... CLARA, Calif. , Sept. 2, 2014   ... is now offering a special promotion for Invisalign. Invisalign ... of brackets and wires. It is often the orthodontic ... prefer the convenience and aesthetics of it. For a ... which is a significant savings from the usual cost. ...
Breaking Medicine Technology:Lawsuit Challenges Iowa Health Mandate that Forces Employers to Pay More for Prescription Drugs 2RVX-208 führt bei Patienten mit Diabetes mellitus zu einer Verringerung des relativen Risikos von gravierenden unerwünschten Herzkreislaufereignissen um 77 % 2RVX-208 führt bei Patienten mit Diabetes mellitus zu einer Verringerung des relativen Risikos von gravierenden unerwünschten Herzkreislaufereignissen um 77 % 3RVX-208 führt bei Patienten mit Diabetes mellitus zu einer Verringerung des relativen Risikos von gravierenden unerwünschten Herzkreislaufereignissen um 77 % 4RVX-208 führt bei Patienten mit Diabetes mellitus zu einer Verringerung des relativen Risikos von gravierenden unerwünschten Herzkreislaufereignissen um 77 % 5RVX-208 führt bei Patienten mit Diabetes mellitus zu einer Verringerung des relativen Risikos von gravierenden unerwünschten Herzkreislaufereignissen um 77 % 6Santa Clara Cosmetic Dentist, Dr. Alan Frame, is Now Offering a Special on Invisalign 2
... Inc. (Nasdaq: ENMD ), a clinical-stage pharmaceutical company ... Wei-Wu He, Ph.D has joined the Board of Directors as ... a member of the Board of Directors. (Logo: ... currently the CEO and Chairman of OriGene Technologies, Inc. He ...
...  United Therapeutics Corporation (NASDAQ: UTHR ) today ... on February 3, 2012 from Sandoz Inc. (Sandoz) advising ... (ANDA) to the U.S. Food and Drug Administration (FDA) ... 10 mg/mL strength of Remodulin® (treprostinil) injection.  ...
Cached Medicine Technology:Biotech Leaders Wei-Wu He, Ph.D and Tak W. Mak, Ph.D Join EntreMed's Board of Directors 2Biotech Leaders Wei-Wu He, Ph.D and Tak W. Mak, Ph.D Join EntreMed's Board of Directors 3Biotech Leaders Wei-Wu He, Ph.D and Tak W. Mak, Ph.D Join EntreMed's Board of Directors 4United Therapeutics Receives Paragraph IV Notice Letter for Remodulin 2
Allograft implants can be easily used to repair and promote the healing of a wide variety of bone and other tissue defects....
Allograft implants can be easily used to repair and promote the healing of a wide variety of bone and other tissue defects....
... Solo Lumbar Allografts are ... that maximizes compressive strength and ... permits the use of preferred ... healing. Specially designed instruments facilitate ...
... comprised of two cortical planks of ... cortical planks provide strength for anterior ... a lattice for remodeling, ensuring an ... surface teeth increase the stability of ...
Medicine Products: