Navigation Links
New prion protein discovered by Canadian scientists may offer insight into mad cow disease
Date:8/16/2007

Scientists have discovered a new protein that may offer fresh insights into brain function in mad cow disease. Our team has defined a second prion protein called Shadoo, that exists in addition to the well-known prion protein called PrP said Professor David Westaway, director of the Centre for Prions and Protein Folding Diseases at the University of Alberta.

For decades we believed PrP was a unique nerve protein that folded into an abnormal shape and caused prion disease: end of story. This view is no longer accurate, Westaway adds.

The study was conducted jointly by the University of Toronto, University of Alberta, Case Western Reserve University (Ohio) and the McLaughlin Research Institute (Montana). The research is published today in the EMBO Journal and represents a culmination of work initiated at the University of Toronto in 1999, and then continued more recently at the University of Alberta.

This is the first discovery since 1985 of a new brain prion protein. A second prion protein had been inferred by other research, based on indirect studies and the examination of DNA sequences, said lead author Joel Watts, a graduate student at the University of Torontos Centre for Research in Neurodegenerative Diseases. But we not only demonstrate that this theoretical protein really exists and shares several properties with healthy PrP; we have also defined an unexpected alteration in prion infections.

As the PrP molecule alters shape and accumulates in a prion-affected brain, the Shadoo protein seems to disappear, Watts added. Since proteins in a living cell are the molecules that do the work, this is likely to be significant, he said.

Many facets of a prion disease like BSE are puzzling, Westaway said. The puzzles include the cause of death of brain cells, the function of normal prion proteins, and the rules governing emergence and spread of prions from animal to animal. We believe the Shadoo protein can give us a fresh purchase on these important questions.


'/>"/>
Contact: Bev Betkowski
beverly.betkowski@ualberta.ca
780-492-3808
University of Alberta
Source:Eurekalert

Related medicine news :

1. Prion Disease Agent Causes Heart Damage
2. Single Protein Plays A Major Role In Prion Diseases
3. Role of Hsp 104 in the Spread of Prion Diseases
4. Study Finds Prion Proteins in Milk
5. Vaccine Prevents Prion Disease in Mice
6. Vaccine Prevents Prion Disease in Mice
7. Significant Advances in VCJD Prion Detection
8. Prions Capacity can Be Aggrevated by Solid Particles
9. New Insights into Prion Propogation
10. Prions Prevent Alzheimers Disease
11. Lean Protein Could Be Key to Obesity Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Viejo, California (PRWEB) , ... June 27, 2016 , ... ... are fully customizable inside of Final Cut Pro X," said Christina Austin - CEO ... another unique style. Final Cut Pro X users can now reveal the ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... today announced its strategic partnership with Connance, a healthcare industry leader providing ... companies’ proven, proprietary technology combine to provide health systems, hospitals and ambulatory ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their ... Eyeglasses . , Millions of individuals in the United States and Canada wear eyeglasses. ... way to both correct vision and make a fashion statement. Even celebrities use glasses ...
(Date:6/26/2016)... ... June 26, 2016 , ... On June 10-11, 2016, A Forever ... Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, where the rehabilitation ... as home to some of the world’s leading providers of cereal and other breakfast ...
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research and ... News Issue 52" report to their offering. ... influenza treatment creates a favourable commercial environment for MedImmune to ... patient base that will serve to drive considerable growth for ... would serve to cap sales considerably, but development is still ...
(Date:6/23/2016)... today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in Bogota. ... ... ... ... Astellas is a ...
(Date:6/23/2016)... -- Research and Markets has announced the ... (United States, China, Japan, Brazil, United Kingdom, Germany, France, ... Surgical Procedure Volumes: ... provides surgical procedure volume data in a geographic context. ... analysis of growth drivers and inhibitors, including world population ...
Breaking Medicine Technology: