Navigation Links
New prion protein discovered by Canadian scientists may offer insight into mad cow disease
Date:8/16/2007

Scientists have discovered a new protein that may offer fresh insights into brain function in mad cow disease. Our team has defined a second prion protein called Shadoo, that exists in addition to the well-known prion protein called PrP said Professor David Westaway, director of the Centre for Prions and Protein Folding Diseases at the University of Alberta.

For decades we believed PrP was a unique nerve protein that folded into an abnormal shape and caused prion disease: end of story. This view is no longer accurate, Westaway adds.

The study was conducted jointly by the University of Toronto, University of Alberta, Case Western Reserve University (Ohio) and the McLaughlin Research Institute (Montana). The research is published today in the EMBO Journal and represents a culmination of work initiated at the University of Toronto in 1999, and then continued more recently at the University of Alberta.

This is the first discovery since 1985 of a new brain prion protein. A second prion protein had been inferred by other research, based on indirect studies and the examination of DNA sequences, said lead author Joel Watts, a graduate student at the University of Torontos Centre for Research in Neurodegenerative Diseases. But we not only demonstrate that this theoretical protein really exists and shares several properties with healthy PrP; we have also defined an unexpected alteration in prion infections.

As the PrP molecule alters shape and accumulates in a prion-affected brain, the Shadoo protein seems to disappear, Watts added. Since proteins in a living cell are the molecules that do the work, this is likely to be significant, he said.

Many facets of a prion disease like BSE are puzzling, Westaway said. The puzzles include the cause of death of brain cells, the function of normal prion proteins, and the rules governing emergence and spread of prions from animal to animal. We believe the Shadoo protein can give us a fresh purchase on these important questions.


'/>"/>
Contact: Bev Betkowski
beverly.betkowski@ualberta.ca
780-492-3808
University of Alberta
Source:Eurekalert

Related medicine news :

1. Prion Disease Agent Causes Heart Damage
2. Single Protein Plays A Major Role In Prion Diseases
3. Role of Hsp 104 in the Spread of Prion Diseases
4. Study Finds Prion Proteins in Milk
5. Vaccine Prevents Prion Disease in Mice
6. Vaccine Prevents Prion Disease in Mice
7. Significant Advances in VCJD Prion Detection
8. Prions Capacity can Be Aggrevated by Solid Particles
9. New Insights into Prion Propogation
10. Prions Prevent Alzheimers Disease
11. Lean Protein Could Be Key to Obesity Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... December 09, 2016 , ... Mediaplanet today announces distribution of the ... encouraging readers to sign up as an organ donor for the 123,000 people in ... An organ donor can save up to 8 saves through organ donation and enhance ...
(Date:12/8/2016)... Charleston, WV (PRWEB) , ... December 08, 2016 ... ... that it will become Quality Insights beginning January 1, 2017. The name ... emphasizes its commitment to measuring and improving health care quality. , “We are ...
(Date:12/8/2016)... ... December 08, 2016 , ... Seavest Healthcare ... owned by an affiliate of Seavest, has won a prestigious national healthcare real ... County ambulatory care center (ACC) was named “Best New Development, MOBs and Other ...
(Date:12/8/2016)... , ... December 08, 2016 , ... Premier Fitness Camp ... FIT , the ultimate weight loss and wellness program, at their world headquarters of ... to provide immediate and long-term results to anyone seeking weight loss, personal development, a ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... STAT courier ... to be a convenient service for Texas, they are expanding their presence in Dallas. ... a hiring spree that will bring new jobs to the Dallas and Forth Worth ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... 9, 2016  Axovant Sciences Ltd. (NYSE: ... focused on the treatment of dementia, today announced ... Phase 2b trial evaluating treatment with intepirdine (RVT-101), ... donepezil plus placebo in people with mild-to-moderate Alzheimer,s ... intepirdine to treatment was associated with reduced progression ...
(Date:12/8/2016)... Dec. 8, 2016 Australia Glaucoma Surgery ... GlobalData,s new report, "Australia Glaucoma Surgery Devices Market ... the Australia Glaucoma Surgery Devices market. The report ... (in units) and average prices (USD) within market ... also provides company shares and distribution shares data ...
(Date:12/8/2016)... 8, 2016 KEY FINDINGS The ... in 2017-2023. Various reasons for growth of the medical ... incidences of chronic diseases, high recovery cost of injuries ... Medical lifting sling refers to an assistive device ... These slings connect to the lift and hold the ...
Breaking Medicine Technology: