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New potential treatment for muscular dystrophy appears to be safe
Date:3/11/2008

Myostatin, a protein that blocks muscle growth, has shown promising results as a potential therapeutic target for treating muscular dystrophy in animal studies, where its inhibition led to increased muscle mass and strength. A new study, the first to evaluate a myostatin inhibitor in patients, assessed its safety in adults with muscular dystrophy and found that it was well-tolerated. The study was published today in Annals of Neurology (http://www.interscience.wiley.com/), the official journal of the American Neurological Association.

Muscular dystrophy is an inherited disorder involving progressive muscle weakness and wasting. Although there has been progress in understanding the pathology of this disease, no drug treatments that increase muscle strength have been found. In addition, very few trials have been conducted for muscular dystrophy that begins in adulthood, and none of these involved novel drugs.

A double-blind, randomized study of 116 patients with muscular dystrophy was conducted by researchers from 10 centers in the United States and United Kingdom. Patients with multiple different types of muscular dystrophy were divided into four groups given sequentially higher doses of a myostatin inhibitor called MYO-029 produced by Wyeth Pharmaceuticals. Each group was randomized to receive the test drug or a placebo in a 3:1 ratio. The drug or placebo was administered intravenously every two weeks for six months, after which the patients were followed for three months. Although the purpose of the study was to test for safety, muscle strength and mass were also assessed.

The results showed that safety assessments, including vital signs, laboratory tests and physical examination showed no significant differences between treatment and placebo groups. There were no side effects to skeletal, smooth or cardiac muscle, and the most significant side effects related to the treatment were
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Contact: Sean Wagner
swagner@bos.blackwellpublishing.com
781-388-8550
Blackwell Publishing Ltd.
Source:Eurekalert

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