Navigation Links
New potential drug target for the treatment of atherosclerosis
Date:3/4/2008

roves hyperglycemia.

Cardiovascular disease is a leading cause of death in patients with metabolic syndrome, a clustering of obesity-related disorders including insulin resistance, hypertension, and dyslipidemia, says postdoctoral researcher and first author Grant D. Barish, M.D. Since PPAR delta plays a key role in fat metabolism and PPAR delta drugs can protect against obesity, we wanted to know whether activating PPAR delta would protect against atherosclerosis.

Atherosclerosis or hardening of the arteries" is a chronic disease in which high cholesterol levels coupled with inflammation lead to the build-up of fatty deposits, called plaque, on the inner walls of arteries. Eventually these plaques can limit blood flow, leading to angina, or they may rupture, resulting in blood clots that block arteries and cause heart attacks or strokes.

When the researchers fed an experimental drug that turns on PPAR delta to genetically altered mice that develop the characteristic plaques at an early age, especially when placed on a high-fat diet, mice developed 2530 percent fewer plaques. Further studies revealed that PPAR delta not only raises HDL levels but also suppresses the inflammatory response in the artery, dramatically slowing down lesion progression.

Barish and Evans also contributed to a related study, which was led by researchers at the University of California, Los Angeles and published in the same issue of PNAS. Using a different mouse model to mimic the development of atherosclerosis, the UCLA researchers detected an even more pronounced anti-inflammatory effect that slashed the number of aortic lesions by up to 70 percent.

While Barish, a clinically trained endocrinologist, cautions that extrapolating from mice to humans is inherently fraught with complications, he believes that drugs switching on PPAR delta have the potential to protect against obesity, insulin resistance and their associated cardiovascular risk
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
858-453-410-01340
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Large source of nitrate, a potential water contaminant, found in near-surface desert soils
2. Weill Cornell team identifies potential new drug targets against hormone-dependent breast cancer
3. Alimera Sciences Signs Second Agreement With Emory University for Potential Treatments Using New Class of Antioxidants
4. Researcher of the University of Navarra discovered potential antidepressant compounds
5. Scientists using laser light to detect potential diseases via breath samples, says new study
6. ASAM Calls for Care in the Use of, and the Prescribing of, Potentially Addictive Substances
7. Growing markets bring potential for rubber and oilseed crops
8. Heating Plastic Bottles Releases Potentially Harmful Chemical
9. Hot liquids release potentially harmful chemicals in polycarbonate plastic bottles
10. New nanotube findings by Stanford researchers give boost to potential biomedical applications
11. Battling potential disease outbreaks online
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New potential drug target for the treatment of atherosclerosis
(Date:8/20/2014)... 20, 2014 Get the report here: ... mergermarket presents “Deal Drivers 2014 Half Year Report for ... M&A activity in both North and South America, with ... About Merrill DataSite     , Merrill DataSite is a ... the due diligence process by providing a highly efficient ...
(Date:8/20/2014)... Angeles, CA (PRWEB) August 20, 2014 ... it is bringing on Wrench Advisors as a ... tasks including international large accounts. , As Wrench ... sales consultants can help your organization plan and ... executives and global distribution channels. Our experience developing ...
(Date:8/20/2014)... In its latest blog post, A Forever Recovery ... clients off to a great start and gives them a ... an important and possibly life-changing – perhaps even life-saving – ... understand the insidious nature of drug abuse: it doesn’t discriminate. ... targets a certain socioeconomic group, such as inner-city youth or ...
(Date:8/20/2014)... The award-winning plastic surgery group, The Aesthetic ... throughout Houston to a third office, located in Katy, ... building. ACPS plastic surgeon Dr. Rolando Morales said the ... has risen to become one of the largest, most ... since its establishment in 1996 by plastic surgeons Dr. ...
(Date:8/20/2014)... Antonio, TX (PRWEB) August 20, 2014 Texas ... their new study. The study will help test the effectiveness ... who suffer from high cholesterol may be eligible to participate ... too much cholesterol in the blood can lead to cardiovascular ... States. Lowering cholesterol can help reduce the risk of heart ...
Breaking Medicine News(10 mins):Health News:Register to Download Merrill DataSite's Report: Deal Drivers 2014 Half Year Report for the Americas 2Health News:Biocide Systems Announces Partnership with Wrench Advisors 2Health News:New A Forever Recovery Blog Post Reminds People that Drug Abuse Doesn’t Discriminate 2Health News:New A Forever Recovery Blog Post Reminds People that Drug Abuse Doesn’t Discriminate 3Health News:Aesthetic Center for Plastic Surgery Expands Its Reach in Texas 2Health News:Texas Medical Research Associates Announce New Study 2
... DNA vaccine trials conducted against the AIDS/HIV virus. The ... completed among 40 HIV- negative // volunteers. ... of vaccine biology. It involves direct injection of one ... human body. These vaccines precipitate an immune response so ...
... new generation stents that are deigned for slow release of ... stents according to a recent study conducted on stents used ... effectively prevent the overgrowth of scar tissue, thereby reducing incidence ... can either be inserted into a grafted vein or into ...
Fatehpur Sikri, Mughal Emperor Akbar's dream city, has come up some new finds, thanks to the labourious// excavatory work of the Archaeological Survey of India (ASI). ,According to Munazar Ali, a mo...
... from the University of Lund in Sweden have conducted ... of type 2 diabetes // . ,Exposure ... asthma, diabetes and many cancers. ,High levels of ... dichloro-diphenyl-trichloro-ethane or DDT in the blood of diabetic patients ...
... With the ever-increasing unsafe sex practices, massive migration and ... the incidence of the killer disease // amongst the ... ,Several districts of Orissa including Ganjam, Kendrapara, Balasore Nuapada, ... of HIV incidence, which poses a challenge to the ...
... warning German researchers say that loud noise can increase the ... risk is squarely attributed// to the noise related to the ... ,It was found that this noise had a ... the Institute for Social Medicine, Epidemiology and Health Economics at ...
Cached Medicine News:Health News:DNA Vaccine Trials Against HIV Virus In Sweden Nurture Hope 2Health News:Drug-Eluting Stents Ensure Patency Of The Saphenous Vein Grafts 2Health News:High Decibel Levels Raise Heart Disease Risk 2
(Date:8/20/2014)... Aug. 20, 2014 Reportlinker.com announces that ... its catalogue: Global Coatings for Medical ... This report analyzes the worldwide ... Million by the following Product Segments: Active Coatings, ... report provides separate comprehensive analytics for the US, ...
(Date:8/20/2014)... 20, 2014 ApolloDx™ today announced it will ... a special event at the company,s office in ... 5, 2014. The event, which will start at 10:00 ... www.apollodx.com .    "We believe our ... Jared Bauer , Co-Founder and Managing Partner of ApolloDx. ...
(Date:8/20/2014)... Aug. 20, 2014   Easy Breathe , the fastest growing ... " Easy Blog " - has received more than 4.5 million ... "We are thrilled that so many people are finding our ... of Easy Breathe. "We,re committed to making sleep apnea more widely ... stay informed about sleep apnea news , troubleshooting advice ...
Breaking Medicine Technology:Global Coatings for Medical Devices Industry 2Global Coatings for Medical Devices Industry 3Global Coatings for Medical Devices Industry 4Global Coatings for Medical Devices Industry 5Global Coatings for Medical Devices Industry 6Global Coatings for Medical Devices Industry 7Global Coatings for Medical Devices Industry 8Global Coatings for Medical Devices Industry 9Global Coatings for Medical Devices Industry 10Global Coatings for Medical Devices Industry 11Global Coatings for Medical Devices Industry 12Global Coatings for Medical Devices Industry 13Global Coatings for Medical Devices Industry 14Global Coatings for Medical Devices Industry 15Global Coatings for Medical Devices Industry 16Global Coatings for Medical Devices Industry 17Global Coatings for Medical Devices Industry 18Global Coatings for Medical Devices Industry 19Global Coatings for Medical Devices Industry 20Global Coatings for Medical Devices Industry 21Easy Breathe Blog Emerges as the Go-To Resource for Sleep Apnea Sufferers 2Easy Breathe Blog Emerges as the Go-To Resource for Sleep Apnea Sufferers 3Easy Breathe Blog Emerges as the Go-To Resource for Sleep Apnea Sufferers 4
Jewelers Forceps, delicate, straight....
Forceps, pointed, short jaws, suitable for epilation....
Cilia Forceps, slanted jaws, gold plated....
Accurate implant size. Polyoxymethylene (POM)....
Medicine Products: