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New possibility to determine the severity of appendicitis
Date:6/21/2010

out that this imbalance is important for how damage to the tissue can lead to perforation of the appendix.

"This means that we know more about the molecular mechanisms behind the process that can lead to a perforated appendix", says Anna Solberg.

Furthermore, TIMP-1 reflected the degree of inflammation in the blood at the time for surgery. It is possible that a blood sample measuring the amount of TIMP-1 could become a part of the clinical diagnostic process in the future, and thus determines the severity of the inflammation. However, Anna Solberg points out that more studies with repeated blood samples taken during the course of the disease are required.

"I plan to continue research in the field in order to see whether TIMP-1 can function as a marker of inflammation, in order to determine the diagnosis and predict the disease course. This could lead to more focussed surgery, fewer complications and shorter hospital stays, and it could improve the possibility of giving individual treatment, which also considers the risk of increased resistance to antibiotics."


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Contact: Anna Solberg
anna.solberg@surgery.gu.se
46-313-434-429
University of Gothenburg
Source:Eurekalert

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