Navigation Links
New possibilities for leukemia therapy with a novel mode of leukemia cell recognition
Date:6/24/2014

Singapore, 24 June 2014Scientists at A*STAR's Singapore Immunology Network (SIgN) have discovered a new class of lipids in the leukaemia cells that are detected by a unique group of immune cells. By recognising the lipids, the immune cells stimulate an immune response to destroy the leukaemia cells and suppress their growth. The newly identified mode of cancer cell recognition by the immune system opens up new possibilities for leukaemia immunotherapy .

Leukaemia is characterized by the accumulation of cancer cells originating from blood cells, in the blood or bone marrow. Current treatments for leukaemia largely involve chemotherapy to eradicate all cancer cells, followed by stem cell transplants to restore healthy blood cells in the patients.

In a recent study reported in the Journal of Experimental Medicine (JEM) online, the team co-led by Dr Lucia Mori and Prof Gennaro De Libero identified a new class of lipids, methyl-lysophosphatidic acids (mLPA), which accumulate in leukaemia cells. Following which, the team identified a specific group of immune cells, described as mLPA-specific T-cells that are capable of recognising the mLPA in the leukaemia cells. The detection triggers an immune response that activates the T cells to kill the leukaemia cells and limits cancer progression. The efficacy of the T cells in killing leukaemia cells was also demonstrated in a mouse model of human leukaemia.

Thus far, only proteins in cancer cells have been known to activate T cells. This study is a pioneer in its discovery of mLPA, and the specific T cells which can identify lipids expressed by cancer cells. Unlike proteins, lipids in cancer cells do not differ between individuals, indicating that the recognition of mLPA by mLPA-specific T-cells happens in all leukaemia patients. This new mode of cancer cell recognition suggests that the T-cells can potentially be harnessed for a leukaemia immunotherapy that is effective in all pa
'/>"/>

Contact: Tan Yun Yun
tan_yun_yun@a-star.edu.sg
65-682-66273
Biomedical Sciences Institutes (BMSI)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Newly discovered brown fat cells hold possibilities for treating diabetes, obesity
2. Lipids help to fight leukemia
3. Leukemia drug found to stimulate immunity against many cancer types
4. One in 4 children with leukemia not taking maintenance medication, study shows
5. Mechanisms of ibrutinib resistance identified in chronic lymphocytic leukemia
6. Tiny mutation triggers drug resistance for patients with one type of leukemia
7. Major discovery on the mechanism of drug resistance in leukemia and other cancers
8. New drug for non-Hodgkin lymphoma and chronic lymphocytic leukemia passes early test
9. Novel target found for chemotherapy-resistant leukemia cells
10. Moffitt Cancer Centers phase 3 study may be game-changer for acute myeloid leukemia
11. A gene within a gene contributes to the aggressiveness of acute myeloid leukemia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... Minneapolis, Minnesota (PRWEB) March 02, 2015 ... a new strategic relationship with First Protective Insurance ... new initiative will allow First Protective affiliated advisors ... and implementation support that Secura Consultants delivers. ... is a national leader in the design and ...
(Date:3/1/2015)... Minneapolis, MN (PRWEB) March 02, 2015 ... leader in the ancillary benefits market, announced the ... product offering. PrimeStar Individual Vision Insurance launched today, ... Choice Vision plan will utilize the VSP® Vision ... providers in the private practice space. The PrimeStar ...
(Date:3/1/2015)... 01, 2015 Women’s Excellence is pleased ... terms on their website. There are over 75 terms ... time. , “This gives our patients a better understanding ... terminology that they may not understand. With this resource, our ... mobile optimized) and find terms and phrases that they may not ...
(Date:3/1/2015)... Los Angeles, CA (PRWEB) March 01, 2015 ... will now be possible when using the Quotes Pros ... now available including United auto insurance rates that are ... , Access to the updated agencies and prices available ... a consumer's zip code online. Every system user will ...
(Date:3/1/2015)... Raleigh, NC (PRWEB) March 01, 2015 ... the reason that so many sheet metal workers contract ... of this new report on its website. Click ... the Center for Construction Research and Training monitored 17,345 ... that a disproportionate number of them died of ...
Breaking Medicine News(10 mins):Health News:Secura Consultants and First Protective Insurance Group Announce Strategic Relationship 2Health News:Security Life Insurance Company Launches Individual Vision Insurance Product 2Health News:United Auto Insurance Rates Now Quoted at Consumer Insurance Portal Online 2Health News:New Study Finds Indirect Asbestos Exposure Can Raise Mesothelioma Risk for Sheet Metal Workers, According to Surviving Mesothelioma 2
... TUCSON, Ariz., July 7 The Providence Service Corporation (Nasdaq: ... in California as part of the state,s attempt to close ... we have stated previously, given that our programs in California ... Act (Proposition 63 of 2004), we do not expect to ...
... been linked to fatal overdoses , TUESDAY, July ... of fatal overdoses led U.S. health officials Tuesday ... of using pain medications containing propoxyphene, including Darvon ... of propoxyphene-containing products by adding boxed warnings that ...
... way to eat healthier without sacrificing taste just got easier. ... lovers are invited to discover the great taste of Barilla ... tries and is not completely satisfied with Barilla Whole Grain ... pasta. , , (Photo: http://www.newscom.com/cgi-bin/prnh/20090707/NY41858-a ...
... Crawford Canada,s Bill Johnstone has been named senior vice ... ; CRDB) Global Technical Services (GTS) for the Americas, ... and grow this market-leading service, the Company announced today. ... Crawford worldwide in the high-end, complex loss adjusting market. ...
... KNOXVILLE, Tenn., July 7 TeamHealth Medical Call ... its third Health Care Call Center certificate of ... accrediting organization that establishes quality standards for the ... provides comprehensive medical call center services including nurse ...
... King Pharmaceuticals, Inc. (NYSE: KG ) today announced ... Drug Application (NDA). The Company is not required by ... trials in order to provide additional safety or efficacy data ... of the resubmission plan, and in order to strengthen the ...
Cached Medicine News:Health News:Providence Service Corporation Does Not Expect California Budget Issues to Materially Impact Its Business in the State 2Health News:FDA Mandates Tougher Warnings for Pain Pills 2Health News:Barilla(R) and Celebrity Fitness Coach Bob Greene Challenge Americans to Discover the Great Taste of Whole Grain 2Health News:Barilla(R) and Celebrity Fitness Coach Bob Greene Challenge Americans to Discover the Great Taste of Whole Grain 3Health News:Bill Johnstone Named Senior Vice President of Crawford's Global Technical Services for the Americas 2Health News:TeamHealth Medical Call Center Awarded Third Consecutive URAC Health Call Center Accreditation 2Health News:King Provides Additional Information on the REMOXY(R) NDA Resubmission Plan 2
(Date:3/2/2015)... 2015 Attorney Advertising -- Bronstein, Gewirtz ... behalf of purchasers of the securities of Vitae ... VTAE -News).  Such investors are advised to contact ... coordinator Eitan Kimelman at info@bgandg.com ... whether Vitae Pharmaceuticals and certain of its officers ...
(Date:3/2/2015)... 2015  CANTEL MEDICAL CORP. (NYSE: CMN ... CEO, will be presenting at the Sidoti & Company ... presentation is scheduled for 2:00 PM ET on Monday, ... New York . In addition, Mr. Krakauer, ... be available for separate one-on-one meetings during the day. ...
(Date:3/2/2015)... 2, 2015  CytomX, a biotechnology company developing ... announced the creation of scientific and clinical advisory ... the fields of cancer immunotherapy and antibody drug ... will provide guidance to CytomX on the development ... and Probody drug conjugates. The company identified advisors ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Bronstein, Gewirtz & Grossman, LLC Announces Investigation of Vitae Pharmaceuticals, Inc. 2CytomX Expands Scientific and Clinical Advisory Boards with Leading Experts in Cancer Immunotherapy and Antibody Drug Conjugates 2CytomX Expands Scientific and Clinical Advisory Boards with Leading Experts in Cancer Immunotherapy and Antibody Drug Conjugates 3
... developed in surgeon's desire to have the ... instrument with the strength to maneuver into ... bending or breaking. Arthrotek Hand Instruments are ... the surgeon's hand. This new generation of ...
... Hand Instruments were developed in surgeon's desire ... still having an instrument with the strength ... fear of the bending or breaking. Arthrotek ... to conform to the surgeon's hand. This ...
... Instruments were developed in surgeon's desire to ... having an instrument with the strength to ... of the bending or breaking. Arthrotek Hand ... conform to the surgeon's hand. This new ...
... were developed in surgeon's desire to have ... an instrument with the strength to maneuver ... the bending or breaking. Arthrotek Hand Instruments ... to the surgeon's hand. This new generation ...
Medicine Products: