Navigation Links
New piece found in colorectal cancer puzzle
Date:6/24/2009

Prostasin, a relatively unknown protease enzyme expressed in most epithelial cells, may play a role in the genesis of colorectal cancer. Researchers writing in the open access journal BMC Cancer have associated a reduction in the expression of inhibitors of the enzyme with malignant cellular behavior.

Lotte Vogel, from the University of Copenhagen, worked with a team of Danish and Norwegian researchers to investigate levels of prostasin and its inhibitors in colorectal tissue samples from 222 patients and 23 controls. They found that the mRNA levels of the inhibitor of prostasin, PN-1, increased at both the transition between normal tissue and mild/moderate dysplasia and again at the transition between severe dysplasia and colorectal cancer. According to Vogel, "It has previously been shown that overexpression of prostasin in mammary and prostate cancer cells reduces the invasive properties of cancer cells and that high prostasin expression in gastric tumours is associated with longer survival. In what may be support for this trend, our data shows that elevated mRNA levels for prostasin's inhibitor, PN-1, coincides with the acquisition of malignant properties in colorectal tissue".

The enzymatic activity of prostasin is almost certainly influenced by levels of inhibitors other than PN1, and PN1 itself is known to inhibit many other enzymes. This complex web of interactions between relevant proteases and their inhibitors makes firm conclusions difficult to draw. As Vogel writes, "Future studies are required to clarify whether down-regulation of prostasin activity via up regulation of PN-1 is causing the malignant progression or if it is a consequence of it".


'/>"/>

Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-203-192-2165
BioMed Central
Source:Eurekalert

Page: 1

Related medicine news :

1. Comfort Matters - The new Draeger Series of Filtering Facepiece Respirators Demonstrate Exceptional Wearer Comfort
2. Risk-Management Policies Needed Now in Nanotechnology, Insighter Piece Concludes; FDLI Sponsors Nanotechnology Meeting, Publishes Book on FDA-Regulated Products
3. Juva Skin Banishes Bumps with New UniForm Cellulite Therapy Handpiece
4. Physician Home Visits Centerpiece of New AmeriChoice and INSPIRIS Partnership in Philadelphia
5. Snoring Mouthpiece: Cost effective Solution For Snorers
6. Alma Lasers Announces FDA Clearance of the UniForm Handpiece
7. Heres What It Takes ... to Be Healthy, Wealthy, and Wise: New Self-Help Book Sees Life as Pieces of a Puzzle, Offers Advice on Making Those Pieces Fit
8. A Piece Of Mind: Vitamin B12 May Protect the Brain in Old Age
9. Scientists identify another piece of the weight-control puzzle
10. CoolTouch Introduces CoolBlue Duet(TM) Laser Lipolysis Suction Handpiece
11. Pieces coming together in Parkinsons, cholesterol puzzle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... May 24, 2016 , ... ... corporate identity and website at its “Transforming Outcomes” User Conference in Las Vegas ... reflect i2i’s ongoing success to set the market standard for meaningful population health ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... of communication enabled solutions and managed services today announced a strategic partnership ... enterprise contact center market. , Altura, one of Avaya’s largest Platinum Business ...
(Date:5/24/2016)... Church, VA (PRWEB) , ... May 24, 2016 , ... ... 14-15, 2016 · Raleigh, NC, http://www.fdanews.com/humanerrordrugdevice , Human error is known to ... is unlikely that human error will ever be totally eliminated, many human performance problems ...
(Date:5/24/2016)... ... ... Regenerative Medicine is being transformed by ongoing research and clinical findings at ... results as have been achieved with Okyanos Cell Therapy are paving the ... patients worldwide. , As the Medical Advisory Chairman at Okyanos, Eric Duckers, MD, PhD, ...
(Date:5/24/2016)... ... May 24, 2016 , ... ... or injury that focuses on repairing the musculoskeletal and neuromuscular systems of the ... on functional restoration, NYDNRehab began providing treatments for physical therapy in New York, ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... , May 24, 2016 ... den Markt gebracht, die es Ärzten erlaubt, ihre ... zu behandeln: MDLinking kombiniert Live Streaming mit einer ... Umfeld zu kommunizieren. Mediziner in Europa, Afrika, Asien ... sich bereits für die Plattform registriert. ...
(Date:5/24/2016)... CHRISTCHURCH, New Zealand , May 24, 2016 ... scanning and informatics solutions for the healthcare sector, has been ... the New Zealand Hi-Tech Awards 2016. Dr ... a fantastic acknowledgement for our team.  It,s really good to ... the burden healthcare internationally. Our products are used in 35 ...
(Date:5/24/2016)... , May 24, 2016 ... de doble terapia del mundo, introduce catéteres para ... OrbusNeich, una compañía global especializada en ... vidas, ha expandido su cartera incluyendo productos para ... JADE™ y Scoreflex™ PTA son los dispositivos de ...
Breaking Medicine Technology: