Navigation Links
New phase II study supports potential of gs-9450 as new treatment option for steatohepatitis
Date:4/16/2010

Vienna, Austria, Thursday 15 April: Results from a multinational phase II study presented today at the International Liver CongressTM 2010 have shown that treatment with the caspase inhibitor GS-9450 can reduce markers of liver damage in patients with non-alcoholic steatohepatitis (NASH the most serious form of non-alcoholic liver disease) as demonstrated by reduced levels of alanine (ALT) and aspartate aminotransferases (AST), hepatic enzymes that indicate cell damage.

GS-9450, a potent inhibitor of caspases-8, -9 and -1, the intra-cellular proteins that initiate programmed cell death (or cell suicide, also known as apoptosis) in damaged cells, is a potential new treatment option for patients with NASH a disease characterised by fat build-up in liver cells with subsequent inflammation resulting in accumulation of scar tissue (fibrosis), cirrhosis and eventual liver failure.

Professor Fabio Marra of the EASL scientific committee commented: "It is encouraging to see that GS-9450-associated reduction of apoptosis and cell damage seen in animal models has translated to a significant patient population, and seems to be consistent with a good tolerability profile in patients from a variety of countries. Further studies are needed to evaluate the action of this therapy on histology and to confirm the drug's efficacy and safety in larger patient populations."

In this double-blind, parallel-group study, patients (n=124, principally male, mean age 45 years, with Body Mass Index (BMI) of >30kg/m2) with biopsy-proven NASH were randomised to receive 1, 5, 10 or 40mg GS-9450 or placebo once daily for 4 weeks. After 4 weeks on treatment, patients in the 40mg treatment group experienced the greatest reduction in ALT and AST levels.

At week four, linear regression of ALT versus GS-9450 dose was highly significant (p<0.0001) with 35% achieving ALT levels within the normal range (7-56 U/L ) compared to 0% at study baseline, and 48% achiev
'/>"/>

Contact: Isabelle Scali
media.easl2010@cohnwolfe.com
44-771-743-5103
European Association for the Study of the Liver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. NASA selects DNA Medicine Institutes Nanoscale Diagnostics Technology for Phase II SBIR
2. PRA International Rolls out Client Access to Oracle(R) RDC for Early Phase Studies
3. Treatment for chronic hepatitis C: A phase II study
4. New Pixantrone Phase III Data to be Presented at the 51st Annual Meeting of the American Society of Hematology
5. InstaMed Achieves Core Phase II Certification to Streamline Provider Access to Consistent Electronic Eligibility and Claim Status
6. Pharmacyclics, Inc. Announces Presentation of Interim Results From Phase I Trial of Its First-In-Human Btk Inhibitor PCI-32765
7. Aetna and WellPoint Achieve CORE Phase II Certification
8. Data from Phase 1 Study Confirm High Response Rate of Micromets Blinatumomab in Patients with Non-Hodgkins Lymphoma
9. Pharmacyclics, Inc. Reports Interim Safety and Clinical Data from a Phase I/II Clinical Trial of its Oral HDAC Inhibitor PCI-24781 in Lymphoma at the American Society of Hematology Annual Meeting
10. Hepregen Corporation Receives SBIR Phase II Grant from the National Science Foundation and Presents Corporate Update at OneMed Forum
11. Synomics Pharma and Bioscience Laboratories Announce Partnership to Provide Topical Clinical Phase 1 Study Services
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... In recent years Medical Marijuana has continuously ... as a way for them to expand their patient base ... medicine. Since the FDA still lists Cannabis as a Schedule ... licensed physicians that can help guide them when recommending ... in Santa Cruz, CA is a leader in the ...
(Date:2/28/2015)... February 28, 2015 In a recent ... of Game Change Athlete Development Services ... about the benefits of athlete development and player engagement ... the unique challenges that athletes face and how off-field ... success. , Fletcher became involved in athlete development issues ...
(Date:2/28/2015)... Chicago, IL (PRWEB) February 28, 2015 ... growth, Chunk Fitness has added an additional exercise to ... as the oblique exercise is most commonly known as, ... equipment. , “Rope Pulls” are executed in a relatively ... varying fitness and strength levels. The full description of ...
(Date:2/28/2015)... The Classic Denture Center , ... special. Throughout all of March patients can receive ... service can help overall mouth health and ... may notice certain symptoms that suggest the denture teeth ... include: , 1.    Pain, clicking, and popping in the joints, ...
(Date:2/28/2015)... Mew and Company, a Vancouver corporate tax ... business consulting services in addition to a variety of ... succession planning. Company finances are a complicated matter that ... of this, complex Canadian tax laws can make it ... result, Mew and Company works to advise their clients ...
Breaking Medicine News(10 mins):Health News:Reputable Cannabis Doctor In Santa Cruz and Monterey Joins the Medical Cannabis Network 2Health News:SCI TV Covers Athlete Development with Duncan Fletcher 2Health News:SCI TV Covers Athlete Development with Duncan Fletcher 3Health News:Classic Denture Center in Portland Oregon is Offering March Discount 2Health News:Vancouver Corporate Tax Accountants Now Provide Business Consulting Services 2
... F. Holick, PhD, MD, was recently awarded the 2007 ... Endocrinology and Metabolism (CSEM). Holick, an internationally recognized ... award for decades of pioneering work that elucidated the ... of chronic health conditions. , Holick is ...
... COLUMBIA, Mo. Researchers from the University of Missouri ... vaccines directed against the virus that causes AIDS and ... published in the Dec. 14 edition of The Journal ... than a decade, Gary Clark, associate professor of Obstetrics, ...
... Therapy & Research Center (CTRC) at The University of Texas ... for Cancer Research (AACR) announced today a collaboration for the ... The announcement came at the 30th Annual Charles A. Coltman ... B. Gonzalez Convention Center in San Antonio. As a ...
... of Breast Cancer is Hard to Treat and Occurs Most Often ... in Young Women, African American Women, ... (TNBC), and Susan G. Komen for the Cure convened one of ... aggressive and difficult-to-treat form of the,disease. The meeting was held prior ...
... patients to abortionists, WASHINGTON, Dec. 13 ... following statement regarding the,American College of Obstetricians and ... the organization to force or otherwise,compel doctors to ... "The American College of Obstetricians and Gynecologists, ...
... Global pharmaceutical and consumer products leader selects software for ... multistage inventory planning and optimization, ... enterprise-class supply chain optimization solutions, announced,that its Enterprise Inventory ... EIO enables customers to achieve both a rapid return ...
Cached Medicine News:Health News:Boston University Medical Center researcher honored 2Health News:New study suggests why vaccines directed against cancer, HIV don't work 2Health News:Cancer research giants collaborate to present the CTRC-AACR San Antonio Breast Cancer Symposium 2Health News:Cancer research giants collaborate to present the CTRC-AACR San Antonio Breast Cancer Symposium 3Health News:Researchers From Around the World Gather to Discuss Triple Negative Breast Cancer 2Health News:Researchers From Around the World Gather to Discuss Triple Negative Breast Cancer 3Health News:Researchers From Around the World Gather to Discuss Triple Negative Breast Cancer 4Health News:American Life League President Blasts 'Forced Abortion Referrals' 2
(Date:2/27/2015)... ON , Feb. 27, 2015 /CNW/ - Covalon Technologies ... medical technologies company, today announced financial results for its ... For the three months ended December 31, 2014, revenue ... the quarter was $229,820 or $0.02 per share.  ... , said "I am very pleased with the significant ...
(Date:2/27/2015)... 2015  Uroplasty, Inc. (NASDAQ: UPI ), a ... proprietary products to treat voiding dysfunctions, today announced that ... on Tuesday, March 10, 2015. Rob Kill , ... Financial Officer, will present at 4:00 p.m. Pacific Time ... conference at the Ritz Carlton in Laguna ...
(Date:2/26/2015)... CLARA, Calif. , Feb. 27, 2015  Finesse expands ... Finesse Solutions announced the expansion of its ... opening is planned for mid-March and access for customers ... from the A-563, and located adjacent to the current ... by the Finesse automation engineering team and allow Finesse to ...
Breaking Medicine Technology:Covalon Announces First Quarter Financial Results 2Covalon Announces First Quarter Financial Results 3Uroplasty to Participate in the 27th Annual ROTH Conference 2New Finesse Office in United Kingdom 2