Navigation Links
New peritoneal dialysis diagnostic discovered

London, ON Thanks to a discovery by scientists at Robarts Research Institute and The University of Western Ontario, patients undergoing peritoneal dialysis may soon be able to worry less about the risks of infection and lessen their hospital stays.

Peritoneal dialysis, which involves placing a tube into the peritoneal cavity, allows people who have suffered from kidney failure to carry on a relatively normal life; however, complications include high incidence of infection of the abdominal cavity, known as peritonitis, which most patients experience every year or so.

Led by Joaquin Madrenas, Robarts scientist and Canada Research Chair in Immunobiology at Western, the study has looked at the molecule RIP2 (receptor-interacting protein 2) for clues over the past three years. Though the precise function of RIP2 is not yet known, scientists made the important finding that levels of the molecule increase during infection. More importantly, peritoneal dialysis patients with peritonitis who have high levels of RIP2 can be sent home and treated with antibiotics. If RIP2 levels do not go up, patients risk a protracted infection and should be admitted for closer monitoring and more intense treatment. This information can be used to address the need to admit patients to the hospital.

We currently have no objective indicator if peritonitis will be really bad, so we tend to try to guess how bad it is, says Madrenas. What we have found is that, by monitoring RIP2, we can predict the outcome of the infection in patients taking part in peritoneal dialysis.

By keeping patients out of hospitals, this discovery not only helps improve quality of life, but also reduces strain on the healthcare system.

The team, which includes Madrenas PhD student Michelle McCully and a close collaboration with Dr. Peter Blake of the division of nephrology at Western, will now try to adapt the discovery to a clinical laboratory and hopefully develop a diagnostic test that can be conducted with a patients peritoneal fluid on a routine basis. Madrenas also wonders if there are other factors preventing RIP2 levels from increasing in some patients. If we know what problem is preventing this increase, we could fix it and possibly prevent infections, he says.


Contact: Ann Hutchison
University of Western Ontario

Related medicine news :

1. Death Risk Of Ovarian Cancer Reduced By Intraperitoneal Chemotherapy
2. Recognizing heart risk in dialysis patients
3. Easier Dialysis for Kids
4. More Patients Going In For Home Dialysis
5. Dialysis Clinics Owned By Fresenius Flourishes Due To Its Customers
6. SRN Hospital Dialysis Unit To Resume Function
7. Heparin Based Nanoscale Materials Developed For Dialysis Treatment
8. Exercise Combined with Dialysis Yields Better Results
9. Surveillance Program for Haemodialysis Reduces Infection
10. Vitamin E-Coated Dialysis Filters Help Fight Anemia in Hemodialysis Patients
11. Dialysis Patients With Metabolic Syndrome Show Increased Risk for Heart Disease
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article ... American Dental Association meeting in Washington D.C. revolved around the fact that proper dental ... health. The talk stressed the link between periodontal disease (more commonly referred to as ...
(Date:11/27/2015)... ... ... According to an article published November 15th by ABC News, while ... light of the recent terrorist attacks in Paris, other cities are taking extra precautions ... reaching U.S. soil. Especially around special events that may be high-profile in nature, the ...
(Date:11/27/2015)... ... ... A team of Swiss doctors has released a report on mesothelioma relapse ... the findings on the website. Click here to read the details now. ... who were treated with chemotherapy followed by EPP surgery. Among the 106 patients who ...
(Date:11/27/2015)... ... November 27, 2015 , ... "When ... said an inventor from Hillside, N.J. "Many people catch diseases simply from sitting ... individuals will always be protected from germs." , He developed the patent-pending QUDRATECS ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... the November 27th edition of USA Today in Atlanta, Dallas, New York, Minneapolis, ... of 750,000. The digital component is distributed nationally, through a vast social media ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... 26, 2015 ... "2016 Future Horizons and Growth Strategies ... Market: Supplier Shares, Country Segment Forecasts, Competitive ... offering. --> ) has ... Future Horizons and Growth Strategies in the ...
(Date:11/26/2015)... 26, 2015 ... of the  "2016 Future Horizons and ... Drug Monitoring (TDM) Market: Supplier Shares, ... Opportunities"  report to their offering.  ... the addition of the  "2016 Future ...
(Date:11/26/2015)... 2015 Research and Markets ( ... "2016 Future Horizons and Growth Strategies in the ... Country Segment Forecasts, Competitive Intelligence, Emerging Opportunities" ... --> --> This new 247-page ... therapeutic drug monitoring market, including emerging tests, technologies, ...
Breaking Medicine Technology: