Navigation Links
New peptide communication factor enabling bacteria to 'talk to each other' discovered
Date:10/29/2007

Jerusalem Discovery by Hebrew University of Jerusalem researchers of a new communication factor that enables bacteria to talk to each other and causes their death could have significant consequences leading to development of a new class of antibiotic medications.

Bacteria are traditionally considered unicellular organisms. However, increasing experimental evidence indicates that bacteria seldom behave as isolated organisms. Instead, they are members of a community in which the isolated organisms communicate among themselves, thereby manifesting some multi-cellular behaviors.

In an article published Friday (Oct. 26) in the journal Science, the Hebrew University scientists describe the new communication factor they have discovered that is produced by the intestinal bacteria Escherichia coli. The new factor is secreted by the bacteria and serves as a communication signal between single bacterial cells.

The research was carried out by a group headed by Prof. Hanna Engelberg-Kulka of the Department of Molecular Biology at the Hebrew University Hadassah Medical School. It includes Ph.D. student Ilana Kolodkin-Gal , and a previous Ph.D. student, Dr Ronen Hazan. In addition, the research included Dr Ariel Gaathon from the Facilities Unit of the Medical School.

The communication factor formed by Escherichia coli enables the activation of a built-in suicide module which is located on the bacterial chromosome and is esponsible for bacterial cell death under stressful conditions. Therefore, the new factor has been designated EDF (Extra-cellular Death Factor).

While suicidal cell death is counterproductive for the individual bacterial cell, it becomes effective for the bacterial community as a whole by the simultaneous action of a group of cells that are signaled by EDF. Under stressful conditions in which the EDF is activated, a major sub-population within the bacterial culture dies, allowing the survival of the population as a whole.

Understanding how the EDF functions may provide a lead for a new and more efficient class of antibiotics that specifically trigger bacterial cell death in the intestine bacteria Escherichia coli and probably in many other bacteria, including those pathogens that also carry the suicide module.

The discovered communication factor is a novel biological molecule, noted Prof Engelberg-Kulka. It is a peptide (a very small protein) that is produced by the bacteria. The chemical characterization of the new communication factor was particularly difficult for the researchers because of two main reasons: it is present in the bacterial culture in minute amounts, and the factor decomposes under the conditions that are routinely used during standard chemical characterization methods. Therefore, it was necessary to develop a new specific method. The research has also identified several bacterial genes that are involved in the generation of the communication factor, said Prof. Engelberg-Kulka. .


'/>"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-258-82904
The Hebrew University of Jerusalem  
Source:Eurekalert

Related medicine news :

1. New Insight To The Role Of Peptide Signals
2. Biocon to colloborate for development of Oral peptide drugs for heart diseases.
3. Discovery of Elevated Amyloid Peptide levels could lead to Alzheimer’s Preventio
4. Peptide Found in Human Blood Inhibits 60 Strains of HIV, Study Says
5. Stress Protein Inactivation Cuts Alzheimers Peptide in Mice
6. Specific Imbalance Between Two Peptides may Cause Alzheimers
7. Appetite-regulating Peptides Influence Alcohol Cravings
8. Improved parent-physician communication to prevent hospitalizations for childhood asthma
9. Physician and Patient relationship strained due to non-verbal communications
10. Better Communication With FDA Could Speed Up Approval Of New Drugs
11. Doctoral communication gets wired badge: wireless communication.
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New peptide communication factor enabling bacteria to 'talk to each other' discovered
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... through a world of exterior design possibilities. CertainTeed, North America’s leading brand of ... by expanding the product offerings showcased in the mobile version of the ColorView® ...
(Date:2/12/2016)... SAN LUIS OBISPO, Calif. (PRWEB) , ... February 12, 2016 , ... The Central Coast ... purpose of this dance is to provide a night of fun for teens with and ... to help everyone feel welcomed and included at the event. The dance will take place ...
(Date:2/12/2016)... ... February 12, 2016 , ... Planet Future is a Final Cut ... are great for showcasing pictures, videos as well as text in an exciting cartoon ... thirds, transitions and a beautiful frame overlay. Pixel Film Studios makes editing easy; simply ...
(Date:2/11/2016)... ... February 11, 2016 , ... “ HEALING MIND : Five Steps to ... (published by Balboa Press) teaches readers how to become their own therapist. Providing a ... Janice McDermott, M.Ed., LCSW, offers an understanding of how to heal one’s inner child ...
(Date:2/11/2016)... Whippany, New Jersey (PRWEB) , ... February 11, 2016 , ... ... invited to a free CEU seminar titled, “Stroke Management: Time to Act, Time to ... Senior Housing Community in Whippany, N.J. The presenter is Vishal Chedda, president of ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... 2016  Governor Andrew M. Cuomo today announced a ... throughout Western New York . This ... Polytechnic Institute, includes a major expansion of Athenex,s North ... Buffalo , as well as the creation of ... Dunkirk . The combined projects are expected ...
(Date:2/11/2016)... 11, 2016  MiMedx Group, Inc. (NASDAQ: MDXG ... membrane and other birth tissues, human skin and bone, ... market advanced products and therapies, announced today that it ... Healthcare Conference in New York , ... Michael J. Senken , Chief Financial Officer and ...
(Date:2/11/2016)... tracker, ALEX , has taken Kickstarter by storm, crowdfunding over $60,000 – or 120% of its ... said to be delivered to backers starting May of this year. ... ... ... Created by NAMU, a team of biomedical engineers out of ...
Breaking Medicine Technology: