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New pathway found for regulation of blood vessel growth in cancer
Date:3/1/2012

l clues pointed to a separate function for p14 ARF. P14 ARF is often lost when astrocytoma progresses to glioblastoma, a more deadly form of brain cancer.

"These tumors are bigger, more infiltrative and more vascularized," he says. "Yet p53 is usually lost at an early stage, before this transition takes place. This suggested that p14 ARF has a function that is independent of p53."

Zerrouqi could show that restoring p14 ARF in cells from a tumor that had lost it interfered with the tumor's ability to stimulate blood vessel growth. P14 ARF induces brain cancer cells to secrete a protein called TIMP3, which inhibits vascular cell migration, he found.

Zerrouqi and Van Meir's findings are applicable to brain cancers as well as several other cancer types. TIMP3 itself has been found to be silenced in brain, kidney, colon, breast and lung cancers, suggesting that it is an obstacle to their growth.


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Contact: Lynne Anderson
virginia.l.anderson@emory.edu
404-778-5452
Emory University
Source:Eurekalert

Page: 1 2

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